miRNA targets in ECM and membrane receptors (WP2911)

Homo sapiens

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Based on the KEGG ECM-receptor interactions pathway (hsa04512), a depiction a plausible mechanism, where miRNAs regulate components of both extracellular matrix (top panel) and transmembrane receptors (bottom panel) to mediate cell-to-cell communications. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2911 CPTAC Assay Portal].

Authors

Kristina Hanspers , Friederike Ehrhart , Elisa Cirillo , Martina Summer-Kutmon , Susan Coort , and Eric Weitz

Activity

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Organisms

Homo sapiens

Communities

ExRNA

Annotations

Pathway Ontology

cell-extracellular matrix signaling pathway regulatory pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
LAMA4 GeneProduct ensembl:ENSG00000112769
SDC2 GeneProduct ensembl:ENSG00000169439
mir-30c-1 GeneProduct ensembl:ENSG00000207962
mir-30d-3p GeneProduct ensembl:ENSG00000199153
COL3A1 GeneProduct ensembl:ENSG00000168542
THBS2 GeneProduct ensembl:ENSG00000186340
COL4A2 GeneProduct ensembl:ENSG00000134871
COL4A1 GeneProduct ensembl:ENSG00000187498
COL5A3 GeneProduct ensembl:ENSG00000080573
COL6A1 GeneProduct ensembl:ENSG00000142156
COL6A2 GeneProduct ensembl:ENSG00000142173
COL1A2 GeneProduct ensembl:ENSG00000164692
COL5A2 GeneProduct ensembl:ENSG00000204262
COL6A3 GeneProduct ensembl:ENSG00000163359
COL5A1 GeneProduct ensembl:ENSG00000130635
TNXB GeneProduct ensembl:ENSG00000168477
LAMB2 GeneProduct ensembl:ENSG00000172037
THBS1 GeneProduct ensembl:ENSG00000137801
LAMC1 GeneProduct ensembl:ENSG00000135862
FN1 GeneProduct ensembl:ENSG00000115414
mir-30c-2 GeneProduct ensembl:ENSG00000199094
mir-29c-5p GeneProduct mirbase.mature:MIMAT0004673
mir-141-5p GeneProduct ensembl:ENSG00000207708
mir-148b-3p GeneProduct ensembl:ENSG00000199122
mir-200a-5p GeneProduct ensembl:ENSG00000207607
mir-25-3p GeneProduct ensembl:ENSG00000207547
mir-532-5p GeneProduct ensembl:ENSG00000207758
mir-589-5p GeneProduct ensembl:ENSG00000207973
mir-548d-1 GeneProduct ensembl:ENSG00000207704
mir548d-2 GeneProduct ensembl:ENSG00000207688
mir-141-3p GeneProduct ensembl:ENSG00000207708
mir-30b-5p GeneProduct ensembl:ENSG00000207582
MIR92A2 GeneProduct ensembl:ENSG00000284538
mir-200c-3p GeneProduct ensembl:ENSG00000207713
ITGB6 GeneProduct ensembl:ENSG00000115221
ITGB5 GeneProduct ensembl:ENSG00000082781
ITGA11 GeneProduct ensembl:ENSG00000137809
ITGA1 GeneProduct ensembl:ENSG00000213949
mir-200b-3p GeneProduct ensembl:ENSG00000207730
mir-200c-5p GeneProduct ensembl:ENSG00000207713
mir-200b-5p GeneProduct ensembl:ENSG00000207730
mir-429 GeneProduct ensembl:ENSG00000198976

References

  1. Potential microRNA-mediated oncogenic intercellular communication revealed by pan-cancer analysis. Li Y, Zhang Z. Sci Rep. 2014 Nov 18;4:7097. PubMed Europe PMC Scholia