Sulindac metabolic pathway (WP2542)

Homo sapiens

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Metabolism of sulindac sulfide is catalyzed by MsrA, MsrB2, and MsrB3.

For a description of pathway objects, see the WikiPathways Legend.

Authors

Egon Willighagen , Marianthi Kalafati , Martina Summer-Kutmon , Max Van Son , Denise Slenter , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

xenobiotic metabolic pathway classic metabolic pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
Sulfindac sulfide Metabolite chemspider:4509492
Sulindac-S Metabolite pubchem.compound:11245227
Sulindac-R Metabolite pubchem.compound:16046677
Sulindac sulfone Metabolite chemspider:4582441 The structure for the sulfone in the paper is inconsistent with the entries in ChemSpider and PubChem; I assume the paper made typographic errors.
CYP1B1 GeneProduct ensembl:ENSG00000138061
MsrB2 GeneProduct ensembl:ENSG00000148450
MsrA GeneProduct ensembl:ENSG00000175806
FMO3 GeneProduct ensembl:ENSG00000007933
MsrB3 GeneProduct ensembl:ENSG00000174099
CYP1A2 GeneProduct ensembl:ENSG00000140505

References

  1. Stereoselective sulfoxidation of sulindac sulfide by flavin-containing monooxygenases. Comparison of human liver and kidney microsomes and mammalian enzymes. Hamman MA, Haehner-Daniels BD, Wrighton SA, Rettie AE, Hall SD. Biochem Pharmacol. 2000 Jul 1;60(1):7–17. PubMed Europe PMC Scholia
  2. Reduction of Sulindac to its active metabolite, sulindac sulfide: assay and role of the methionine sulfoxide reductase system. Etienne F, Resnick L, Sagher D, Brot N, Weissbach H. Biochem Biophys Res Commun. 2003 Dec 26;312(4):1005–10. PubMed Europe PMC Scholia
  3. Studies on the metabolism and biological activity of the epimers of sulindac. Brunell D, Sagher D, Kesaraju S, Brot N, Weissbach H. Drug Metab Dispos. 2011 Jun;39(6):1014–21. PubMed Europe PMC Scholia