Spinal cord injury (WP2433)
Rattus norvegicus
This pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multi-step process that involves the regulation of gene expression and signaling in motor neurons, oligodentrocytes, microglia, and astrocytes that trigger immediate immune responses lasting several weeks. Within 24 hours, chemoattractants and cytokines released from the site of injury activate neutrophils which further recruit B and T cells or recruit monocytes that ultimately result in infiltration and activation by microglia and macrophages. These immune responses result in inflammation, excitotoxicity, cell death, formation of glial scar, and suppression of axonal regeneration. An increase in the expression of cell cycle genes further results in proliferation of astrocytes and microglia that leads to apoptosis and necrosis of oligodentrocytes and neurons.
Authors
Nathan Salomonis , Egon Willighagen , Deborah Micael , Chris Evelo , Alex Pico , Martina Summer-Kutmon , Linda Rieswijk , and Eric WeitzActivity
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Cited In
- Unraveling the blood transcriptome after real-life exposure of Wistar-rats to PM2.5, PM1 and water-soluble metals in the ambient air (2020).
- Organophosphorus flame retardants are developmental neurotoxicants in a rat primary brainsphere in vitro model (2020).
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Organisms
Rattus norvegicusCommunities
Annotations
Disease Ontology
spinal cord disease post-traumatic stress disorderCell Type Ontology
astrocyte of the spinal cordPathway Ontology
disease pathwayReferences
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