Serotonin and anxiety (WP2141)
Mus musculus
Benekareddy et al observed the phenomenon that rats who were maternally separated show increased levels of induced anxiety-related behaviour during adulthood. Type 2 serotonin receptors have been implicated in anxiety related behaviour and may be suitable targets for reducing anxiety response. Benekareddy et al report that treatment with ketanserin (a serotonergic antagonist) during postnatal life blocked the long-lasting effects of maternal separation on anxiety behavior in the open field test and the elevated plus maze. Immediate Early Genes such as Arc have been found to be significantly affected in expression (Benekareddy et al). The downstream and upstream gene products of Arc were partly elucidated and presented in a pathway.
Authors
Helix , Onne Ronda , Andra Waagmeester , Daniela Digles , Egon Willighagen , Martina Summer-Kutmon , Kristina Hanspers , and Denise SlenterActivity
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Organisms
Mus musculusCommunities
Annotations
Pathway Ontology
serotonin signaling pathway altered calcineurin signaling pathway calcium/calmodulin dependent kinase signaling pathwayDisease Ontology
anxiety disorderCell Type Ontology
serotonergic neuron| Label | Type | Compact URI | Comment |
|---|---|---|---|
| THDOC | Metabolite | pubchem.compound:91475 | |
| Ketanserin | Metabolite | pubchem.compound:3822 | |
| Ca2+ | Metabolite | chebi:29108 | |
| Ca2+ | Metabolite | chebi:29108 | |
| Ca2+ | Metabolite | chebi:29108 | |
| DOC | Metabolite | pubchem.compound:6166 | |
| Plcd4 | GeneProduct | ensembl:ENSMUSG00000026173 | |
| Plek | GeneProduct | ensembl:ENSMUSG00000020120 | pleckstrin |
| Pomc | GeneProduct | ensembl:ENSMUSG00000020660 | |
| mGluR1 | GeneProduct | ensembl:ENSMUSG00000019828 | G-protein-coupled phosphatidylinositol-calcium second messenger system |
| Trpv1 | GeneProduct | ensembl:ENSMUSG00000005952 | |
| Prkcb | GeneProduct | ensembl:ENSMUSG00000052889 | Protein kinase C |
| CaM | GeneProduct | ensembl:ENSMUSG00000057897 | |
| Fmr1 | GeneProduct | ensembl:ENSMUSG00000000838 | |
| eEF2K | GeneProduct | ensembl:ENSMUSG00000073853 | |
| Crh | GeneProduct | ensembl:ENSMUSG00000049796 | |
| Ppp3ca | GeneProduct | ensembl:ENSMUSG00000028161 | calcineurin |
| eEF2-P | GeneProduct | uniprot:P58252 | |
| Gabra1 | GeneProduct | ensembl:ENSMUSG00000010803 | GABA a receptor |
| eEF2K | GeneProduct | ensembl:ENSMUSG00000073853 | Phosphorylates eEF2 |
| Arc | GeneProduct | ensembl:ENSMUSG00000022602 | Calcium ion channel |
| Htr2c | GeneProduct | ensembl:ENSMUSG00000041380 | |
| Fos | GeneProduct | ensembl:ENSMUSG00000021250 | |
| Htr1a | GeneProduct | ensembl:ENSMUSG00000021721 | |
| Adra1a | GeneProduct | ensembl:ENSMUSG00000045875 | |
| Arc | GeneProduct | ensembl:ENSMUSG00000022602 | |
| eEF2 | GeneProduct | uniprot:P58252 | |
| Htr2a | GeneProduct | ensembl:ENSMUSG00000034997 | |
| mGluR1 | GeneProduct | ensembl:ENSMUSG00000019828 | G-protein-coupled phosphatidylinositol-calcium second messenger system |
| eEF2-P | GeneProduct | uniprot:P58252 | |
| Arc | GeneProduct | ensembl:ENSMUSG00000022602 |
References
- The alpha-adrenergic receptor blocking effect of ketanserin and the interaction between alpha-adrenergic and S2-serotonergic receptor blockade. van der Starre PJ, Reneman RS. J Cardiovasc Pharmacol. 1988;11 Suppl 1:S54-61. PubMed Europe PMC Scholia
- ARC channels: a novel pathway for receptor-activated calcium entry. Shuttleworth TJ, Thompson JL, Mignen O. Physiology (Bethesda). 2004 Dec;19:355–61. PubMed Europe PMC Scholia
- Physiological role of adrenal deoxycorticosterone-derived neuroactive steroids in stress-sensitive conditions. Reddy DS. Neuroscience. 2006;138(3):911–20. PubMed Europe PMC Scholia
- The immediate early gene arc/arg3.1: regulation, mechanisms, and function. Bramham CR, Worley PF, Moore MJ, Guzowski JF. J Neurosci. 2008 Nov 12;28(46):11760–7. PubMed Europe PMC Scholia
- Postnatal serotonin type 2 receptor blockade prevents the emergence of anxiety behavior, dysregulated stress-induced immediate early gene responses, and specific transcriptional changes that arise following early life stress. Benekareddy M, Vadodaria KC, Nair AR, Vaidya VA. Biol Psychiatry. 2011 Dec 1;70(11):1024–32. PubMed Europe PMC Scholia
- Calcineurin is required for TRPV1-induced long-term depression of hippocampal interneurons. Jensen T, Edwards JG. Neurosci Lett. 2012 Feb 29;510(2):82–7. PubMed Europe PMC Scholia