BMP signaling pathway (WP211)

Danio rerio

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The bone morphogenetic protein (BMP) signalling pathway play critical roles in germ layer induction and patterning in early zebrafish embryos. Smad2/3 and Smad1/5/8 are intracellular effectors of BMPs. These Smads regulate, in cooperation with other factors, transcription of hundreds of target genes in the nucleus. The activity and stability of Smads are regulated by phosphorylation modifications.

Authors

Gabby Krens , Kristina Hanspers , Thomas Kelder , Christine Chichester , Martina Summer-Kutmon , Denise Slenter , Egon Willighagen , Lauren J. Dupuis , and Laurent Winckers

Activity

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Organisms

Danio rerio

Communities

Annotations

Pathway Ontology

Bone morphogenetic proteins signaling pathway

Participants

Label Type Compact URI Comment
bmp1b GeneProduct ncbigene:559877
msx a GeneProduct ncbigene:30528 http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000017825
vent GeneProduct ncbigene:64810 http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000017456
bmp6 GeneProduct ensembl:ENSDARG00000015686
tbx2a GeneProduct ncbigene:30247
bmp5l GeneProduct ncbigene:337711
bmp1l GeneProduct ncbigene:30204
bmpr1a GeneProduct ncbigene:58145 http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000026768
bambi GeneProduct ncbigene:431736 http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000078899
hrb GeneProduct ensembl:ENSDART00000043960 http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000043960
smad1 GeneProduct ncbigene:30628 http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000033566
snai2 GeneProduct ensembl:ENSDART00000033566
acvr2b GeneProduct ensembl:ENSDARG00000044422
bmper GeneProduct ensembl:ENSDARG00000040893
bmp5 GeneProduct ncbigene:394026 http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000019239
tbx2b GeneProduct ncbigene:30253
bmp5 GeneProduct ncbigene:394026
follistatin GeneProduct ncbigene:30235 http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000051065
bmp1a GeneProduct ensembl:ENSDARG00000069054
gata5 GeneProduct ncbigene:30482
twsg1a GeneProduct ensembl:ENSDART00000049963 http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000049963
snai1a GeneProduct ensembl:ENSDARG00000056995
smad6a GeneProduct ensembl:ENSDARG00000053209 http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000014508
id3 GeneProduct ncbigene:246093 http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000021064
bmpr1bb GeneProduct ensembl:ENSDARG00000075729
bmp2b/swirl(swr) GeneProduct uniprot:O93369 http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000060734
msx c GeneProduct ncbigene:30526 http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000014176
smurf-1(WWP1) GeneProduct ensembl:ENSDART00000004923 http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000004923
bmp2b GeneProduct uniprot:O93369
rack1 (gnb2l1) GeneProduct ncbigene:30722 http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000061001
smad1 GeneProduct ncbigene:30628
smad6 GeneProduct ensembl:ENSDARG00000031763
bmp4 GeneProduct ncbigene:30612
gata6 GeneProduct ncbigene:58076
deltaNP63/tp73l GeneProduct ncbigene:325581 http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000065137
crim1 GeneProduct ncbigene:404210
deltaNP63/tp73l GeneProduct ncbigene:335185 http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000065137
rpl15 GeneProduct ensembl:ENSDARG00000009285 http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000034837
smad8 GeneProduct ensembl:ENSDART00000028618 http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000028618
bmp15 GeneProduct ensembl:ENSDARG00000037491
deltaNP63/tp73l GeneProduct ncbigene:325581 http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000065285
bmp3 GeneProduct ncbigene:335252
bmp1b/tolloid GeneProduct ncbigene:335826 http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000059795
gata2 GeneProduct ncbigene:30480
smad4 GeneProduct ensembl:ENSDARG00000045094
gata3 GeneProduct ncbigene:30458
follistatin-like 1 GeneProduct ensembl:ENSDARG00000015559
smad7 GeneProduct ensembl:ENSDARG00000016858 http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000024277
bmp1b/tolloid GeneProduct ncbigene:559877 http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000059795
bmp1a/tolloid GeneProduct wikidata:Q29772966 http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000033284
prdc GeneProduct ncbigene:378455 http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000024960
bambi GeneProduct ncbigene:83496
smurf2 GeneProduct ensembl:ENSDARG00000038067
msx d GeneProduct ncbigene:30531 http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000003441
acvr1/lost a fin (laf) GeneProduct ncbigene:30615 http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000017977
gata4 GeneProduct ncbigene:30483
pcca GeneProduct ncbigene:437019 http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000034097
Nucleoporin like protein RAB GeneProduct ncbigene:393560 http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000021158
follistatin GeneProduct ncbigene:557352 http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000034851
bambi GeneProduct ncbigene:83496 http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000077732
Ubiquitin carrier protein GeneProduct ncbigene:565498 http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000047452
smad4 GeneProduct ncbigene:30640 http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000035478
msx e GeneProduct uniprot:Q90455 http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000002232
chordin/dino(din) GeneProduct ensembl:ENSDART00000045110 http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000045110
noggin2 GeneProduct ensembl:ENSDART00000063231 http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000063231
deltaNP63/tp73l GeneProduct ncbigene:260407 http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000065137
bmp8 GeneProduct ncbigene:378445
bmp2a GeneProduct ncbigene:30631
goosecoid GeneProduct ensembl:ENSDARG00000059073
gremlin 1 GeneProduct ncbigene:405778 http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000043382
smad1 GeneProduct ncbigene:323405 http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000033566
twsg1b GeneProduct ncbigene:259304 http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000059299
bmpr2 GeneProduct ncbigene:562822 http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000056764
crim1 GeneProduct ensembl:ENSDARG00000029668
bmp4 GeneProduct ncbigene:30612 http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000075150
gremlin 1 GeneProduct ncbigene:405778 http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000076092
admp GeneProduct ncbigene:140619
msx e GeneProduct ncbigene:30527 http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000002232
bmp7/snailhouse (snh) GeneProduct ncbigene:30584 http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000016472
acvrl1/violet beauregarde (vbg) GeneProduct ncbigene:266753 http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000043462
noggin1 GeneProduct ensembl:ENSDART00000081766 http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000081766
bmpr1ba GeneProduct ensembl:ENSDARG00000104100
bmpr2 GeneProduct ncbigene:555655 http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000002334
bmpr1ab GeneProduct ensembl:ENSDART00000066309 http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000066309
snip1 GeneProduct ncbigene:474374
kheper/zfhx1 GeneProduct ensembl:ENSDART00000047724 http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000047724
follistatin like GeneProduct ensembl:ENSDART00000080772 http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000080772
smad5/somitabun (sbn) GeneProduct ncbigene:30641 http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000054175
msx b GeneProduct ncbigene:30511 http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000008486
follistatin 2 GeneProduct uniprot:Q2PMI4 http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000080772
snai1b GeneProduct ensembl:ENSDARG00000046019
smad4 GeneProduct ensembl:ENSDARG00000023527
prdc GeneProduct ncbigene:550399 http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000024960
tolloid-like 1/mini fin (mfn) GeneProduct ncbigene:474335 http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000054472
noggin3 GeneProduct ncbigene:30173
vox GeneProduct ncbigene:64807 http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000008176
gata1/vlad tepes (vlt) GeneProduct ensembl:ENSDARG00000013477
smad6b GeneProduct ensembl:ENSDARG00000031763 http://www.ensembl.org/Danio_rerio/searchview?_q=ENSDART00000014508

References

  1. ERK1 and ERK2 MAPK are key regulators of distinct gene sets in zebrafish embryogenesis. Krens SFG, Corredor-Adámez M, He S, Snaar-Jagalska BE, Spaink HP. BMC Genomics. 2008 Apr 28;9:196. PubMed Europe PMC Scholia
  2. Detection of Smad Signaling in Zebrafish Embryos. Liu X, Wang Q, Meng A. Methods Mol Biol. 2016;1344:275–86. PubMed Europe PMC Scholia