Alzheimer's disease (WP2075)

Mus musculus

This pathway displays current genes, proteolytic events and other processes associated with the progression of Alzheimer's disease. This pathway was adapted from KEGG on 10/7/2011. Note: mitochondrial associated genes Cx I through Cx V are not currently included, as these correspond to over a hundred distinct factors. See below source URL for more information.

Authors

Kristina Hanspers , Egon Willighagen , Lovnish Thakur , Friederike Ehrhart , Lauren J. Dupuis , Laurent Winckers , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Mus musculus

Communities

Annotations

Disease Ontology

Alzheimer's disease

Pathway Ontology

disease pathway Alzheimer's disease pathway

Participants

Label Type Compact URI Comment
NO Metabolite hmdb:HMDB0003378
Iron Metabolite hmdb:HMDB0000692
Hydrogen peroxide Metabolite hmdb:HMDB0003125
IP3 Metabolite hmdb:HMDB0001498
Copper Metabolite hmdb:HMDB0000657
Calcium Metabolite hmdb:HMDB0000464
ONOO- Metabolite hmdb:HMDB0002179
Nae1 GeneProduct ensembl:ENSMUSG00000031878
App GeneProduct ensembl:ENSMUSG00000022892
Apbb1 GeneProduct ensembl:ENSMUSG00000037032
Gm2221 GeneProduct ensembl:ENSMUSG00000090825
Adam10 GeneProduct ensembl:ENSMUSG00000054693
Bace1 GeneProduct ensembl:ENSMUSG00000032086
Psenen GeneProduct ensembl:ENSMUSG00000036835
Psen1 GeneProduct ensembl:ENSMUSG00000019969
Ncstn GeneProduct ensembl:ENSMUSG00000003458
Aph1a GeneProduct ensembl:ENSMUSG00000015750
Ide GeneProduct ensembl:ENSMUSG00000056999
Mme GeneProduct ensembl:ENSMUSG00000027820
Lpl GeneProduct ensembl:ENSMUSG00000015568
Apoe GeneProduct ensembl:ENSMUSG00000002985
Lrp1 GeneProduct ensembl:ENSMUSG00000040249
Fas GeneProduct ensembl:ENSMUSG00000024778
Tnfrsf1a GeneProduct ensembl:ENSMUSG00000030341
Fadd GeneProduct ensembl:ENSMUSG00000031077
Casp8 GeneProduct ensembl:ENSMUSG00000026029
Hsd17b10 GeneProduct ensembl:ENSMUSG00000025260
Bid GeneProduct ensembl:ENSMUSG00000004446
Gm10121 GeneProduct ensembl:ENSMUSG00000062813
Calm2 GeneProduct ensembl:ENSMUSG00000036438
1500003O03Rik GeneProduct ncbigene:56398
Bad GeneProduct ensembl:ENSMUSG00000024959
Calml3 GeneProduct ensembl:ENSMUSG00000063130
Calm4 GeneProduct ensembl:ENSMUSG00000033765
Ppp3ca GeneProduct ensembl:ENSMUSG00000028161
Ppp3cb GeneProduct ensembl:ENSMUSG00000021816
Ppp3cc GeneProduct ensembl:ENSMUSG00000022092
Ppp3r1 GeneProduct ensembl:ENSMUSG00000033953
Ppp3r2 GeneProduct ensembl:ENSMUSG00000028310
2010110P09Rik GeneProduct ncbigene:70261
Adam17 GeneProduct ensembl:ENSMUSG00000052593
Psen2 GeneProduct ensembl:ENSMUSG00000010609
Apaf1 GeneProduct ensembl:ENSMUSG00000019979
Casp9 GeneProduct ensembl:ENSMUSG00000028914
Casp3 GeneProduct ensembl:ENSMUSG00000031628
Snca GeneProduct ensembl:ENSMUSG00000025889
Grin1 GeneProduct ensembl:ENSMUSG00000026959
Cacna1c GeneProduct ensembl:ENSMUSG00000051331
Grin2a GeneProduct ensembl:ENSMUSG00000059003
Grin2b GeneProduct ensembl:ENSMUSG00000030209
Grin2c GeneProduct ensembl:ENSMUSG00000020734
Grin2d GeneProduct ensembl:ENSMUSG00000002771
Cacna1d GeneProduct ensembl:ENSMUSG00000015968
Cacna1f GeneProduct ensembl:ENSMUSG00000031142
Cacna1s GeneProduct ensembl:ENSMUSG00000026407
Gnaq GeneProduct ensembl:ENSMUSG00000024639
Plcb1 GeneProduct ensembl:ENSMUSG00000051177
Plcb2 GeneProduct ensembl:ENSMUSG00000040061
Plcb3 GeneProduct ensembl:ENSMUSG00000024960
Plcb4 GeneProduct ensembl:ENSMUSG00000039943
Tnf GeneProduct ensembl:ENSMUSG00000024401
Il1b GeneProduct ensembl:ENSMUSG00000027398
Mapk1 GeneProduct ensembl:ENSMUSG00000063358
Mapk3 GeneProduct ensembl:ENSMUSG00000063065
Casp12 GeneProduct ensembl:ENSMUSG00000025887
Ryr3 GeneProduct ensembl:ENSMUSG00000057378
Atp2a2 GeneProduct ensembl:ENSMUSG00000029467
Atp2a1 GeneProduct ensembl:ENSMUSG00000030730
Atp2a3 GeneProduct ensembl:ENSMUSG00000020788
Eif2ak3 GeneProduct ensembl:ENSMUSG00000031668
Ern1 GeneProduct ensembl:ENSMUSG00000020715
Atf6 GeneProduct ensembl:ENSMUSG00000026663
Itpr1 GeneProduct ensembl:ENSMUSG00000030102
Itpr2 GeneProduct ensembl:ENSMUSG00000030287
Itpr3 GeneProduct ensembl:ENSMUSG00000042644
Capn1 GeneProduct ensembl:ENSMUSG00000024942
Capn2 GeneProduct ensembl:ENSMUSG00000026509
Trp53 GeneProduct ensembl:ENSMUSG00000059552
Cdk5r1 GeneProduct ensembl:ENSMUSG00000048895
Nos1 GeneProduct ensembl:ENSMUSG00000029361
Cdk5 GeneProduct ensembl:ENSMUSG00000028969
Tau GeneProduct ensembl:ENSMUSG00000018411
Gsk3b GeneProduct ensembl:ENSMUSG00000022812
Casp7 GeneProduct ensembl:ENSMUSG00000025076

References

  1. Possible causes of Alzheimer’s disease: amyloid fragments, free radicals, and calcium homeostasis. Hölscher C. Neurobiol Dis. 1998 Sep;5(3):129–41. PubMed Europe PMC Scholia
  2. Neuronal apoptosis induced by beta-amyloid is mediated by caspase-8. Ivins KJ, Thornton PL, Rohn TT, Cotman CW. Neurobiol Dis. 1999 Oct;6(5):440–9. PubMed Europe PMC Scholia
  3. Neurotoxicity induces cleavage of p35 to p25 by calpain. Lee MS, Kwon YT, Li M, Peng J, Friedlander RM, Tsai LH. Nature. 2000 May 18;405(6784):360–4. PubMed Europe PMC Scholia
  4. Alzheimer’s disease and Abeta toxicity: from top to bottom. Small DH, Mok SS, Bornstein JC. Nat Rev Neurosci. 2001 Aug;2(8):595–8. PubMed Europe PMC Scholia
  5. Alzheimer’s disease pathogenesis and therapeutic interventions. Parihar MS, Hemnani T. J Clin Neurosci. 2004 Jun;11(5):456–67. PubMed Europe PMC Scholia
  6. Apoptotic mechanisms in Alzheimer neurofibrillary degeneration: cause or effect? Dickson DW. J Clin Invest. 2004 Jul;114(1):23–7. PubMed Europe PMC Scholia
  7. Pathways towards and away from Alzheimer’s disease. Mattson MP. Nature. 2004 Aug 5;430(7000):631–9. PubMed Europe PMC Scholia
  8. Induction of neuronal death by ER stress in Alzheimer’s disease. Katayama T, Imaizumi K, Manabe T, Hitomi J, Kudo T, Tohyama M. J Chem Neuroanat. 2004 Sep;28(1–2):67–78. PubMed Europe PMC Scholia
  9. Mitochondrial dysfunction, endoplasmic reticulum stress, and apoptosis in Alzheimer’s disease. Takuma K, Yan SS, Stern DM, Yamada K. J Pharmacol Sci. 2005 Mar;97(3):312–6. PubMed Europe PMC Scholia
  10. The role of cerebral amyloid beta accumulation in common forms of Alzheimer disease. Gandy S. J Clin Invest. 2005 May;115(5):1121–9. PubMed Europe PMC Scholia
  11. Tau phosphorylation and aggregation in Alzheimer’s disease pathology. Avila J. FEBS Lett. 2006 May 22;580(12):2922–7. PubMed Europe PMC Scholia
  12. Mitochondrial dysfunction in sporadic and genetic Alzheimer’s disease. Hauptmann S, Keil U, Scherping I, Bonert A, Eckert A, Müller WE. Exp Gerontol. 2006 Jul;41(7):668–73. PubMed Europe PMC Scholia
  13. Distinct destructive signal pathways of neuronal death in Alzheimer’s disease. Shen Y, He P, Zhong Z, McAllister C, Lindholm K. Trends Mol Med. 2006 Dec;12(12):574–9. PubMed Europe PMC Scholia
  14. Presenilin-mediated signal transduction. Cowburn RF, Popescu BO, Ankarcrona M, Dehvari N, Cedazo-Minguez A. Physiol Behav. 2007 Sep 10;92(1–2):93–7. PubMed Europe PMC Scholia
  15. Calcium dysregulation in Alzheimer’s disease. Bojarski L, Herms J, Kuznicki J. Neurochem Int. 2008;52(4–5):621–33. PubMed Europe PMC Scholia
  16. Neuronal calcium mishandling and the pathogenesis of Alzheimer’s disease. Bezprozvanny I, Mattson MP. Trends Neurosci. 2008 Sep;31(9):454–63. PubMed Europe PMC Scholia
  17. Selective induction of calcineurin activity and signaling by oligomeric amyloid beta. Reese LC, Zhang W, Dineley KT, Kayed R, Taglialatela G. Aging Cell. 2008 Dec;7(6):824–35. PubMed Europe PMC Scholia