Effects of nitric oxide (WP1995)

Homo sapiens

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NO (Nitric oxide) is an important signalling molecule with vasodilatory and anti-inflammatory effects, indicating a postive role in reducing hypertension and cardiovascular disease. At the same time, NO is also associated with health risks such as increased risk in carcinogenesis, and hypoxia in infants. It has been suggested that NO can also increase mitochondrial efficiency. NO can be formed from L-Arginine through the classic Arginine-NO-Synthase pathway, or it can be formed directly from dietary nitrite by deoxiginated globins.

Authors

Martijn Van Iersel , Alex Pico , Martina Summer-Kutmon , and Eric Weitz

Activity

last edited

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Organisms

Homo sapiens

Communities

Micronutrients

Annotations

Pathway Ontology

cardiovascular system homeostasis pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
Nitric oxide Metabolite hmdb:HMDB0003378
Nitrate Metabolite hmdb:HMDB0002878
Citrulline Metabolite hmdb:HMDB0000904
VItamin C Metabolite hmdb:HMDB0000044
Nitrite Metabolite hmdb:HMDB0002786
L-Arginine Metabolite hmdb:HMDB0000517
Oxygen Metabolite hmdb:HMDB0001377
NOS3 (endothelial) GeneProduct ncbigene:4846
Deoxy-hemoglobin GeneProduct ensembl:ENSG00000206172
Deoxy-myoglobin GeneProduct ncbigene:4151
NOS1 (neuronal) GeneProduct ncbigene:4842
COX1 GeneProduct ncbigene:4512
NOS2 (inducible) GeneProduct ncbigene:4843
XDH GeneProduct ensembl:ENSG00000158125
AOX1 Protein ensembl:ENSG00000138356

References

  1. Food sources of nitrates and nitrites: the physiologic context for potential health benefits. Hord NG, Tang Y, Bryan NS. Am J Clin Nutr. 2009 Jul;90(1):1–10. PubMed Europe PMC Scholia
  2. Nitrate and nitrite in biology, nutrition and therapeutics. Lundberg JO, Gladwin MT, Ahluwalia A, Benjamin N, Bryan NS, Butler A, et al. Nat Chem Biol. 2009 Dec;5(12):865–9. PubMed Europe PMC Scholia
  3. Dietary inorganic nitrate improves mitochondrial efficiency in humans. Larsen FJ, Schiffer TA, Borniquel S, Sahlin K, Ekblom B, Lundberg JO, et al. Cell Metab. 2011 Feb 2;13(2):149–59. PubMed Europe PMC Scholia