Biogenic amine synthesis (WP154)
Danio rerio
Biogenic amines are one of two broad classes of classical neurotransmitters (the other being amino acids) and include: acetylcholine, serotonin, histamine, and the catecholamines epinephrine, norepinephrine, and dopamine. Synthesis pathways for biogenic amines (in blue) follow solid arrows through enzymatic steps, while degradation steps follow the dashed arrows. Source: http://www.whatislife.com/reader2/Metabolism/pathway/Neurotransmitter.html
Authors
Alex Pico , Thomas Kelder , Egon Willighagen , Christine Chichester , Martina Summer-Kutmon , Denise Slenter , and Eric WeitzActivity
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Organisms
Danio rerioCommunities
Annotations
Pathway Ontology
biogenic amine biosynthetic pathway dopamine degradation pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Acetylserotonin | Metabolite | wikidata:Q4847704 | |
| Epinephrine | Metabolite | wikidata:Q132621 | |
| Tryptophane | Metabolite | chebi:27897 | |
| Choline | Metabolite | chebi:15354 | |
| Serotonin | Metabolite | chebi:28790 | |
| Dopamine | Metabolite | chebi:18243 | |
| Norepinephrine | Metabolite | chebi:33569 | |
| Histamine | Metabolite | chebi:58432 | |
| Melatonin | Metabolite | chebi:16796 | |
| Tyrosine | Metabolite | chebi:18186 | |
| Phenylalanine | Metabolite | chebi:17295 | |
| Acetylcholine | Metabolite | chebi:15355 | |
| Histidine | Metabolite | chebi:27570 | |
| 5-Hydroxy-tryptophan | Metabolite | chebi:17780 | |
| L-DOPA | Metabolite | chebi:15765 | |
| GABA | Metabolite | wikidata:Q210021 | |
| Glutamate | Metabolite | chebi:14321 | |
| gad1 | GeneProduct | ncbigene:378441 | |
| HDC | GeneProduct | ncbigene:793609 | |
| aanat1 | GeneProduct | ncbigene:393677 | |
| COMTa | GeneProduct | ensembl:ENSDARG00000015337 | |
| ddc | GeneProduct | ncbigene:406651 | |
| DBH | GeneProduct | ncbigene:30505 | |
| CHAT | GeneProduct | ncbigene:100170938 | |
| tph1 | GeneProduct | ncbigene:352943 | |
| ASMT | GeneProduct | ensembl:ENSDARG00000098249 | |
| pah | GeneProduct | ncbigene:378962 | |
| ache | GeneProduct | ncbigene:114549 | |
| zgc:112198 | GeneProduct | ncbigene:550403 | |
| TH | GeneProduct | ncbigene:30384 | |
| COMPTb | GeneProduct | ensembl:ENSDARG00000078918 |