Sucrose biosynthesis (WP14)
Saccharomyces cerevisiae
Sucrose is synthesized from the precursors UDP-glucose and fructose 6-phosphate, which are converted into sucrose 6-phosphate by the enzyme sucrose-6-phosphate synthase. Sucrose 6-phosphate is then dephosphorylated by sucrose phosphatase, resulting in the formation of sucrose, which can be exported to other tissues. Although the reaction catalyzed by sucrose 6-phosphate synthase is energetically unfavorable, the hydrolysis of sucrose 6-phosphate to sucrose is highly exergonic, driving the overall synthesis of sucrose in an essentially irreversible manner.
Authors
Meredith Braymer , Alex Pico , Thomas Kelder , Egon Willighagen , Daniela Digles , Denise Slenter , and Eric WeitzActivity
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Organisms
Saccharomyces cerevisiaeCommunities
Annotations
Pathway Ontology
sucrose biosynthetic pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Sucrose-6-phosphate | Metabolite | chebi:131603 | |
| H2O | Metabolite | chebi:15377 | |
| UDP | Metabolite | chebi:17659 | |
| UDP-D-glucose | Metabolite | chebi:18066 | |
| UTP | Metabolite | chebi:15713 | |
| phosphate | Metabolite | cas:14265-44-2 | |
| ADP | Metabolite | cas:58-64-0 | |
| ATP | Metabolite | cas:1927-31-7 | |
| fructose | Metabolite | cas:7776-48-9 | |
| glucose-6-phosphate | Metabolite | cas:59-56-3 | |
| fructose-6-phosphate | Metabolite | cas:643-13-0 | |
| glucose-1-phosphate | Metabolite | chebi:16077 | |
| sucrose | Metabolite | cas:57-50-1 | |
| pyrophosphate | Metabolite | cas:2466-09-3 | |
| YHL012W | GeneProduct | ensembl:YHL012W | |
| UGP1 | GeneProduct | sgd:UGP1 | |
| PGM1 | GeneProduct | sgd:PGM1 | |
| PGM2 | GeneProduct | sgd:PGM2 | |
| FBP1 | GeneProduct | sgd:FBP1 | |
| PGI1 | GeneProduct | sgd:PGI1 |
References
- Sucrose and Saccharomyces cerevisiae: a relationship most sweet. Marques WL, Raghavendran V, Stambuk BU, Gombert AK. FEMS Yeast Res. 2016 Feb;16(1):fov107. PubMed Europe PMC Scholia