Oxidation by cytochrome P450 (WP1390)

Danio rerio

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Oxidation of a substrate by Cytochrome P450. Adapted from Niesink et al., Chapter 3, p. 47-48.

For a description of pathway objects, see the WikiPathways Legend.

Authors

Kristina Hanspers , Egon Willighagen , Friederike Ehrhart , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Danio rerio

Communities

Annotations

Cell Type Ontology

hepatocyte

Pathway Ontology

xenobiotics biodegradation pathway phase I biotransformation pathway via cytochrome P450

Participants

Label Type Compact URI Comment
NADPH Metabolite chebi:16474
O₂ Metabolite hmdb:HMDB0001377
Fe³⁺ Metabolite chebi:29034
H₂O Metabolite pubchem.compound:962
NADP+ Metabolite chebi:18009
Fe²⁺ Metabolite chebi:29033
NADH Metabolite chebi:16908
NAD+ Metabolite chebi:15846
cyp26a1 GeneProduct ensembl:ENSDARG00000033999
CYP4F2 GeneProduct ensembl:ENSDARG00000053530
cyb5b GeneProduct ensembl:ENSDARG00000053954
dia1 GeneProduct ensembl:ENSDARG00000018966
cyb5a GeneProduct ensembl:ENSDARG00000055643
cyp4 GeneProduct ensembl:ENSDARG00000004964
cyp1b1 GeneProduct ensembl:ENSDARG00000068934
zgc:112177 GeneProduct ensembl:ENSDARG00000020898
zgc:153291 GeneProduct ensembl:ENSDARG00000051925
cyp11b2 GeneProduct ensembl:ENSDARG00000042014
CYP27B1 GeneProduct ensembl:ENSDARG00000045015
cyp26c1 GeneProduct ensembl:ENSDARG00000056029
cyp51 GeneProduct ensembl:ENSDARG00000042641
LOC570455 GeneProduct ensembl:ENSDARG00000008858
LOC793249 GeneProduct ensembl:ENSDARG00000037550
cyp26b1 GeneProduct ensembl:ENSDARG00000077121
zgc:63920 GeneProduct ensembl:ENSDARG00000069018
zgc:174342 GeneProduct ensembl:ENSDARG00000053068
si:dkey-69h9.1 GeneProduct ensembl:ENSDARG00000017982
A9JRH5_DANRE GeneProduct ensembl:ENSDARG00000056587
CYP46A1 GeneProduct ncbigene:553543
cyp1a GeneProduct ensembl:ENSDARG00000026039
cyp4v2 GeneProduct ensembl:ENSDARG00000062132
cyp2u1 GeneProduct ensembl:ENSDARG00000026548
cyp11a1 GeneProduct ensembl:ENSDARG00000002347
zgc:63986 GeneProduct ensembl:ENSDARG00000006040
POR GeneProduct ncbigene:568202
cyp17a1 GeneProduct ensembl:ENSDARG00000033566
cyp27c1 GeneProduct ensembl:ENSDARG00000058439
cyb5r3 GeneProduct ensembl:ENSDARG00000005891
cyp24a1l GeneProduct ensembl:ENSDARG00000070420

References

  1. Toxicology [Internet]. Niesink R, Hollinger MA, De Vries J. CRC Press; 1996. 1312 p. Available from: https://books.google.com/books/about/Toxicology.html?hl=&id=mwN9QgAACAAJ OpenLibrary Worldcat
  2. Identification and developmental expression of the full complement of Cytochrome P450 genes in Zebrafish. Goldstone JV, McArthur AG, Kubota A, Zanette J, Parente T, Jönsson ME, et al. BMC Genomics. 2010 Nov 18;11:643. PubMed Europe PMC Scholia
  3. Xenobiotic metabolism in the zebrafish: a review of the spatiotemporal distribution, modulation and activity of Cytochrome P450 families 1 to 3. Saad M, Cavanaugh K, Verbueken E, Pype C, Casteleyn C, Van Ginneken C, et al. J Toxicol Sci. 2016 Feb;41(1):1–11. PubMed Europe PMC Scholia