Matrix metalloproteinases (WP129)
Homo sapiens
Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases; other family members are adamalysins, serralysins, and astacins. The MMPs belong to a larger family of proteases known as the metzincin superfamily. Collectively they are capable of degrading all kinds of extracellular matrix proteins, but also can process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands (such as the FAS ligand), and chemokine/cytokine in/activation. MMPs are also thought to play a major role on cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis and host defense. Source: [[wikipedia:Matrix_metalloproteinase|Wikipedia]] Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP129 CPTAC Assay Portal]
Authors
Kdahlquist , Martijn Van Iersel , Kristina Hanspers , Thomas Kelder , Daniela Digles , Martina Summer-Kutmon , and Eric WeitzActivity
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Cited In
- Target and drug predictions for SARS-CoV-2 infection in hepatocellular carcinoma patients (2022).
- The Biological Interaction of SARS-CoV-2 Infection and Osteoporosis: A Preliminary Study (2022).
- Adverse outcome pathways as a tool for the design of testing strategies to support the safety assessment of emerging advanced materials at the nanoscale (2020).
- Interactive neuroinflammation pathways and transcriptomics-based identification of drugs and chemical compounds for schizophrenia (2023).
- A Data Fusion Pipeline for Generating and Enriching Adverse Outcome Pathway Descriptions.
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
cell-extracellular matrix signaling pathway protein degradation pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| MMP2 | GeneProduct | ncbigene:4313 | |
| MMP9 | GeneProduct | ncbigene:4318 | |
| MMP7 | GeneProduct | ncbigene:4316 | |
| MMP12 | GeneProduct | ncbigene:4321 | |
| MMP20 | GeneProduct | ncbigene:9313 | |
| MMP10 | GeneProduct | ncbigene:4319 | |
| MMP3 | GeneProduct | ncbigene:4314 | |
| MMP11 | GeneProduct | ncbigene:4320 | |
| MMP19 | GeneProduct | ncbigene:4327 | |
| MMP14 | GeneProduct | ncbigene:4323 | |
| MMP15 | GeneProduct | ncbigene:4324 | |
| MMP16 | GeneProduct | ncbigene:4325 | |
| MMP17 | GeneProduct | ncbigene:4326 | |
| MMP24 | GeneProduct | ncbigene:10893 | |
| TIMP2 | GeneProduct | ncbigene:7077 | |
| TIMP3 | GeneProduct | ncbigene:7078 | |
| TIMP4 | GeneProduct | ncbigene:7079 | |
| BSG | GeneProduct | ncbigene:682 | |
| TNF | GeneProduct | ncbigene:7124 | |
| MMP26 | GeneProduct | ncbigene:56547 | |
| MMP28 | GeneProduct | ncbigene:79148 | |
| MMP23A | GeneProduct | ensembl:ENSG00000215914 | |
| MMP25 | GeneProduct | ncbigene:64386 | |
| MMP27 | GeneProduct | ncbigene:64066 | |
| TCF20 | GeneProduct | ncbigene:6942 | |
| MMP21 | GeneProduct | ncbigene:118856 | |
| MMP1 | GeneProduct | ncbigene:4312 | |
| MMP8 | GeneProduct | ncbigene:4317 | |
| MMP13 | GeneProduct | ncbigene:4322 | |
| TIMP1 | GeneProduct | ncbigene:7076 | |
| MMP23B | GeneProduct | ncbigene:8510 |
References
- Matrix metalloproteinases: effectors of development and normal physiology. Vu TH, Werb Z. Genes Dev. 2000 Sep 1;14(17):2123–33. PubMed Europe PMC Scholia