Folic acid network (WP1273)
Mus musculus
The folic acid-centred micronutrient biological network. The most relevant biochemical processes related to folic acid in the context of metabolism, oxidation and inflammation are represented. Also, the compartmental separation (intracellular vs. plasma) is presented, identifying the folic acid centred plasma metabolome.
Authors
Kristina Hanspers , Samuel Sklar , Egon Willighagen , Christine Chichester , Laurent Winckers , Eric Weitz , Alex Pico , and Lars WillighagenActivity
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Organisms
Mus musculusCommunities
Annotations
Pathway Ontology
folate metabolic pathwayLabel | Type | Compact URI | Comment |
---|---|---|---|
Zinc | Metabolite | hmdb:HMDB0015532 | |
Vitamin B12 | Metabolite | hmdb:HMDB0000607 | |
L-Glutamic acid | Metabolite | hmdb:HMDB0000148 | |
Lipoic acid | Metabolite | hmdb:HMDB0001451 | |
Homocysteine | Metabolite | hmdb:HMDB0000742 | |
Cobalamin | Metabolite | hmdb:HMDB0002174 | |
DHA (n-3) | Metabolite | hmdb:HMDB0002183 | |
Uric acid | Metabolite | hmdb:HMDB0000289 | |
Glycine | Metabolite | hmdb:HMDB0000123 | |
Tryptophan | Metabolite | hmdb:HMDB0000929 | |
Leukotriene B4 | Metabolite | hmdb:HMDB0001085 | |
LeukotrieneE4 | Metabolite | hmdb:HMDB0002200 | |
a-tocopherol | Metabolite | hmdb:HMDB0001893 | |
Pyridoxal-5'-phosphate | Metabolite | hmdb:HMDB0001491 | |
S-Adenosylhomocysteine | Metabolite | hmdb:HMDB0000939 | |
PGG2 | Metabolite | hmdb:HMDB0003235 | |
Nicotinamide | Metabolite | pubchem.compound:936 | |
Glutathione | Metabolite | hmdb:HMDB0000125 | |
Copper | Metabolite | hmdb:HMDB0000657 | |
15-HETE | Metabolite | hmdb:HMDB0011134 | |
Lipoxin A4 | Metabolite | hmdb:HMDB0004385 | |
Adipic acid | Metabolite | hmdb:HMDB0000448 | |
S-Adenosylmethionine | Metabolite | hmdb:HMDB0001185 | |
Calcium | Metabolite | hmdb:HMDB0000464 | |
Leukotriene C4 | Metabolite | hmdb:HMDB0001198 | |
Manganese | Metabolite | hmdb:HMDB0001333 | |
LA (n-6) | Metabolite | hmdb:HMDB0000673 | |
Adipic acid | Metabolite | hmdb:HMDB0000448 | |
S-Adenosylmethionine | Metabolite | hmdb:HMDB0001185 | |
Choline | Metabolite | hmdb:HMDB0000097 | |
Methionine sulfoxide | Metabolite | hmdb:HMDB0002005 | |
Ascorbic acid | Metabolite | hmdb:HMDB0000044 | |
L-Methionine | Metabolite | hmdb:HMDB0000696 | |
Methylmalonic acid | Metabolite | hmdb:HMDB0000202 | |
Methylmalonic acid | Metabolite | hmdb:HMDB0000202 | |
Thromboxane A2 | Metabolite | hmdb:HMDB0001452 | |
PGI2 | Metabolite | hmdb:HMDB0001335 | |
C22:5 (n-6) | Metabolite | hmdb:HMDB0001976 | |
Methionine | Metabolite | hmdb:HMDB0000696 | |
Leukotriene A4 | Metabolite | hmdb:HMDB0001337 | |
NADPH | Metabolite | hmdb:HMDB0000221 | |
Iron | Metabolite | hmdb:HMDB0000692 | |
FAD | Metabolite | pubchem.compound:703 | |
Thromboxane B2 | Metabolite | hmdb:HMDB0003252 | |
Leukotriene D4 | Metabolite | hmdb:HMDB0003080 | |
Cysteine | Metabolite | hmdb:HMDB0000574 | |
Carnitine | Metabolite | hmdb:HMDB0000062 | |
Selenium | Metabolite | hmdb:HMDB0001349 | |
AA (n-6) | Metabolite | hmdb:HMDB0001043 | |
5-HPETE | Metabolite | hmdb:HMDB0001193 | |
Riboflavin | Metabolite | hmdb:HMDB0000244 | |
Betaine | Metabolite | hmdb:HMDB0000043 | |
NADP | Metabolite | hmdb:HMDB0000217 | |
Tromboxane A2 | Metabolite | hmdb:HMDB0001452 | |
O2 | Metabolite | hmdb:HMDB0001377 | |
F2-Isoprostane | Metabolite | hmdb:HMDB0004659 | |
1-methylnicotinamide | Metabolite | hmdb:HMDB0000699 | |
H2O | Metabolite | hmdb:HMDB0002111 | |
5,10-METHYL-THF | Metabolite | hmdb:HMDB0001396 | |
Ethanolamine | Metabolite | hmdb:HMDB0000149 | |
PGE3 | Metabolite | hmdb:HMDB0002664 | |
ALA (n-3) | Metabolite | hmdb:HMDB0001388 | |
FOLIC ACID | Metabolite | hmdb:HMDB0000121 | |
Heme | Metabolite | hmdb:HMDB0003178 | |
iPF2-alpha | Metabolite | hmdb:HMDB0004659 | |
Serine | Metabolite | hmdb:HMDB0000187 | |
PGF2a | Metabolite | hmdb:HMDB0001139 | |
Xanthine | Metabolite | hmdb:HMDB0000292 | |
a Tocopherol | Metabolite | hmdb:HMDB0001893 | |
EPA (n-3) | Metabolite | hmdb:HMDB0001999 | |
1-Methylnicotinamide | Metabolite | hmdb:HMDB0000699 | |
2-Ketobutyric acid | Metabolite | hmdb:HMDB0000005 | |
H2O2 | Metabolite | hmdb:HMDB0003125 | |
Hypoxanthine | Metabolite | hmdb:HMDB0000157 | |
Lipoxin B4 | Metabolite | hmdb:HMDB0005082 | |
PGD2 | Metabolite | hmdb:HMDB0001403 | |
Niacin | Metabolite | hmdb:HMDB0001406 | |
PGH2 | Metabolite | hmdb:HMDB0001381 | |
Cystathione | Metabolite | hmdb:HMDB0000099 | |
ROS | Metabolite | chebi:26523 | http://en.wikipedia.org/wiki/Reactive_oxygen_species |
Glutathione disulfide | Metabolite | pubchem.compound:65359 | |
FMN1 | GeneProduct | ncbigene:342184 | |
Ptges | Protein | ncbigene:64292 | |
Ptgis | Protein | ncbigene:19223 | |
Gpx6 | Protein | ncbigene:75512 | |
Fads2 | Protein | ncbigene:56473 | |
Cbs | Protein | ncbigene:12411 | |
Txnrd2 | Protein | ncbigene:26462 | |
Cat | Protein | ncbigene:12359 | |
Mthfr | Protein | ncbigene:17769 | |
Kmo | Protein | ncbigene:98256 | |
Gpx2 | Protein | ncbigene:14776 | |
Ptgds | Protein | ncbigene:19215 | |
Selk | Protein | ncbigene:80795 | |
Sepw1 | Protein | ncbigene:20364 | |
Gpx3 | Protein | ncbigene:14778 | |
Mtr | Protein | ncbigene:238505 | |
Alox5 | Protein | ncbigene:11689 | |
COX1 | Protein | ncbigene:3337205 | |
Sepx1 | Protein | ncbigene:27361 | |
Gsr | Protein | ensembl:ENSMUSG00000031584 | |
Thioredoxin | Protein | ncbigene:7295 | |
Xdh | Protein | ncbigene:22436 | |
Txnrd1 | Protein | ncbigene:50493 | |
Pnpo | Protein | ncbigene:103711 | |
Gpx1 | Protein | ncbigene:14775 | |
COX2 | Protein | ncbigene:3337209 | |
Gpx4 | Protein | ncbigene:625249 |
References
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- Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline [Internet]. of Medicine I, and Nutrition Board F, on Upper Reference Levels of Nutrients S, Standing Committee on the Scientific Evaluation of Dietary Reference Intakes and its Panel on Folate and C Other B Vitamins. National Academies Press; 2000. 592 p. Available from: https://books.google.com/books/about/Dietary_Reference_Intakes_for_Thiamin_Ri.html?hl=&id=ac99DATK8eAC OpenLibrary Worldcat
- Cystathionine beta-synthase deficiency: a qualitative abnormality of the deficient enzyme modified by vitamin B6 therapy. Longhi RC, Fleisher LD, Tallan HH, Gaull GE. Pediatr Res. 1977 Feb;11(2):100–3. PubMed Europe PMC Scholia
- Transcobalamins I and II as natural transport proteins of vitamin B12. Hall CA. J Clin Invest. 1975 Nov;56(5):1125–31. PubMed Europe PMC Scholia
- Vitamin B12 binders (transcobalamins) in serum. Fernandes-Costa F, Metz J. Crit Rev Clin Lab Sci. 1982;18(1):1–30. PubMed Europe PMC Scholia
- Synthesis and biological activities of leukotriene F4 and leukotriene F4 sulfone. Denis D, Charleson S, Rackham A, Jones TR, Ford-Hutchinson AW, Lord A, et al. Prostaglandins. 1982 Dec;24(6):801–14. PubMed Europe PMC Scholia
- The isoprostanes. Current knowledge and directions for future research. Morrow JD, Roberts LJ 2nd. Biochem Pharmacol. 1996 Jan 12;51(1):1–9. PubMed Europe PMC Scholia
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- Human methionine synthase: cDNA cloning and identification of mutations in patients of the cblG complementation group of folate/cobalamin disorders. Leclerc D, Campeau E, Goyette P, Adjalla CE, Christensen B, Ross M, et al. Hum Mol Genet. 1996 Dec;5(12):1867–74. PubMed Europe PMC Scholia
- A common variant in methionine synthase reductase combined with low cobalamin (vitamin B12) increases risk for spina bifida. Wilson A, Platt R, Wu Q, Leclerc D, Christensen B, Yang H, et al. Mol Genet Metab. 1999 Aug;67(4):317–23. PubMed Europe PMC Scholia
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- WikiPathways: WP28