Retinol metabolism (WP1259)

Mus musculus

This pathway is about carotenoid metabolism. It is mainly created by the NuGO focusteam on Carotenoid metabolism. Finally it was subject to a text mining workflow which added some additional entities.

Authors

Alex Pico , Samuel Sklar , Jun Ding , Kristina Hanspers , Strand Life Sciences Pvt. Ltd , Thomas Kelder , Daniela Digles , Egon Willighagen , and Martina Summer-Kutmon

Activity

last edited

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Cited In

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Organisms

Mus musculus

Communities

Annotations

Pathway Ontology

retinol metabolic pathway

Participants

Label Type Compact URI Comment
beta-cryptoxanthin Metabolite hmdb:HMDB0002268
zeaxanthin Metabolite hmdb:HMDB0002789
lutein Metabolite hmdb:HMDB0003233
lycopene Metabolite hmdb:HMDB0003000
Vitamin D3 Metabolite hmdb:HMDB0000876
cryptoxanthin Metabolite hmdb:HMDB0002268
violaxanthin Metabolite hmdb:HMDB0003101
canthaxanthin Metabolite hmdb:HMDB0003154
astaxanthin Metabolite hmdb:HMDB0002204
alpha-carotene Metabolite hmdb:HMDB0003993
Bcmo1 GeneProduct ncbigene:63857
Rbp7 GeneProduct ncbigene:63954
Aldh1a1 GeneProduct ncbigene:11668
Rara GeneProduct ncbigene:19401
Aldh1a2 GeneProduct ncbigene:19378
Abcg8 GeneProduct ncbigene:67470
Rdh12 GeneProduct ncbigene:77974
Rdh5 GeneProduct ncbigene:19682
Dhrs3 GeneProduct ncbigene:20148
Cyp26b1 GeneProduct ncbigene:232174
Npc1l1 GeneProduct ncbigene:237636
Aldh1a3 GeneProduct ncbigene:56847
Abcg5 GeneProduct ncbigene:27409
Lpl GeneProduct ncbigene:16956
Cyp2e1 GeneProduct ncbigene:13106
Rpe65 GeneProduct ncbigene:19892
Bcdo2 GeneProduct uniprot:Q99NF1
Scarb1 GeneProduct ncbigene:20778
Sult2b1 GeneProduct ncbigene:54200
Lrat GeneProduct ncbigene:79235
Rxrb GeneProduct ncbigene:20182
Rdh10 GeneProduct ncbigene:98711
Retsat GeneProduct ncbigene:67442
Rbp1 GeneProduct ncbigene:19659
Rxra GeneProduct ncbigene:20181
Adh4 GeneProduct ncbigene:26876
Sult1a1 GeneProduct ncbigene:20887
Cyp26a1 GeneProduct ncbigene:13082
Cd36 GeneProduct ncbigene:12491
Rarg GeneProduct ncbigene:19411
Rdh8 GeneProduct ncbigene:235033
Adh1 GeneProduct ncbigene:11522
Rxrg GeneProduct ncbigene:20183
Crabp2 GeneProduct ncbigene:12904
Crabp1 GeneProduct ncbigene:12903
Rlbp1 GeneProduct ncbigene:19771
Rbp2 GeneProduct ncbigene:19660
Rbp4 GeneProduct ncbigene:19662
Rarb GeneProduct ncbigene:218772

References

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  2. Antioxidant functions of vitamins. Vitamins E and C, beta-carotene, and other carotenoids. Sies H, Stahl W, Sundquist AR. Ann N Y Acad Sci. 1992 Sep 30;669:7–20. PubMed Europe PMC Scholia
  3. Plasma carotenoid response to chronic intake of selected foods and beta-carotene supplements in men. Micozzi MS, Brown ED, Edwards BK, Bieri JG, Taylor PR, Khachik F, et al. Am J Clin Nutr. 1992 Jun;55(6):1120–5. PubMed Europe PMC Scholia
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  7. Interrelationships among liposoluble vitamins in ruminants. Hidiroglou M, Williams CJ. Am J Vet Res. 1986 Aug;47(8):1767–71. PubMed Europe PMC Scholia
  8. Carotenoids in the human macula and whole retina. Handelman GJ, Dratz EA, Reay CC, van Kuijk JG. Invest Ophthalmol Vis Sci. 1988 Jun;29(6):850–5. PubMed Europe PMC Scholia
  9. Seasonal and sex-related variations in six serum carotenoids, retinol, and alpha-tocopherol. Olmedilla B, Granado F, Blanco I, Rojas-Hidalgo E. Am J Clin Nutr. 1994 Jul;60(1):106–10. PubMed Europe PMC Scholia
  10. Relationship between dietary intake and plasma concentrations of carotenoids in premenopausal women: application of the USDA-NCI carotenoid food-composition database. Yong LC, Forman MR, Beecher GR, Graubard BI, Campbell WS, Reichman ME, et al. Am J Clin Nutr. 1994 Aug;60(2):223–30. PubMed Europe PMC Scholia
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  12. Fat-soluble vitamins: biotransformation. Satoh T. Nihon Rinsho. 1993 Apr;51(4):865–70. PubMed Europe PMC Scholia
  13. Acute phase response and plasma carotenoid concentrations in older women: findings from the nun study. Boosalis MG, Snowdon DA, Tully CL, Gross MD. Nutrition. 1996;12(7–8):475–8. PubMed Europe PMC Scholia
  14. Influence of using different sources of carotenoid data in epidemiologic studies. VandenLangenberg GM, Brady WE, Nebeling LC, Block G, Forman M, Bowen PE, et al. J Am Diet Assoc. 1996 Dec;96(12):1271–5. PubMed Europe PMC Scholia
  15. Vitamin A deficiency and nocturnal vision in teenagers with cystic fibrosis. Huet F, Semama D, Maingueneau C, Charavel A, Nivelon JL. Eur J Pediatr. 1997 Dec;156(12):949–51. PubMed Europe PMC Scholia
  16. Vitamin D analogs affect the uptake and metabolism of retinol by human epidermal keratinocytes in culture. Törmä H, Rollman O, Binderup L, Michaelsson G. J Investig Dermatol Symp Proc. 1996 Apr;1(1):49–53. PubMed Europe PMC Scholia
  17. Fruits and vegetables that are sources for lutein and zeaxanthin: the macular pigment in human eyes. Sommerburg O, Keunen JE, Bird AC, van Kuijk FJ. Br J Ophthalmol. 1998 Aug;82(8):907–10. PubMed Europe PMC Scholia
  18. Lycopene and 1,25-dihydroxyvitamin D3 cooperate in the inhibition of cell cycle progression and induction of differentiation in HL-60 leukemic cells. Amir H, Karas M, Giat J, Danilenko M, Levy R, Yermiahu T, et al. Nutr Cancer. 1999;33(1):105–12. PubMed Europe PMC Scholia
  19. Vitamin A antagonizes calcium response to vitamin D in man. Johansson S, Melhus H. J Bone Miner Res. 2001 Oct;16(10):1899–905. PubMed Europe PMC Scholia
  20. Gene expression regulation by retinoic acid. Balmer JE, Blomhoff R. J Lipid Res. 2002 Nov;43(11):1773–808. PubMed Europe PMC Scholia
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  22. Relation of elevated serum alanine aminotransferase activity with iron and antioxidant levels in the United States. Ruhl CE, Everhart JE. Gastroenterology. 2003 Jun;124(7):1821–9. PubMed Europe PMC Scholia
  23. Preliminary identification of carotenoids in malignant and benign neoplasms of the breast and surrounding fatty tissue. Czeczuga-Semeniuk E, Wołczyński S, Markiewicz W. Neoplasma. 2003;50(4):280–6. PubMed Europe PMC Scholia