Transcriptional activation by NRF2 (WP988)

Bos taurus

Open in new tab Open in Newt (SBGN)
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads
Based on [http://www.nature.com/nrc/journal/v3/n10/fig_tab/nrc1189_F4.html Surh, 2003, figure 4]. Nrf2 induces the expression of many antioxidant enzymes. It is therefore thought to be involved in oxidative stress response.

Authors

Egon Willighagen and Martina Summer-Kutmon

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

nuclear factor, erythroid 2 like 2 signaling pathway oxidative stress response pathway

Participants

Label Type Compact URI Comment
Sulforaphane Metabolite hmdb:HMDB0005792
6-HITC Metabolite chemspider:7991398 Full name: 6-(Methylsulfinyl)hexylisothiocyanate, or Japanese horseradish wasabi
Caffeic acid phenethyl ester Metabolite chebi:8062
Curcumin Metabolite hmdb:HMDB0002269
PRKCA GeneProduct ensembl:ENSBTAG00000001061 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5578
MAPK8 GeneProduct ensembl:ENSBTAG00000007876 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5599
AIMP2 GeneProduct ensembl:ENSBTAG00000007367 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7965
NFE2L2 GeneProduct ensembl:ENSBTAG00000019255 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4780
KEAP1 GeneProduct ensembl:ENSBTAG00000003543 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9817
GCLC GeneProduct ensembl:ENSBTAG00000015571 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2729
HMOX1 GeneProduct ensembl:ENSBTAG00000015582 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3162
MAF GeneProduct ensembl:ENSBTAG00000044192 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4094
EPHB2 GeneProduct ensembl:ENSBTAG00000045902 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2048
PIK3CA GeneProduct ensembl:ENSBTAG00000009232 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5290
GSTA2 GeneProduct ensembl:ENSBTAG00000006546 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2939
NQO1 GeneProduct ensembl:ENSBTAG00000020632 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1728
GCLM GeneProduct ensembl:ENSBTAG00000007842 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2730
SLC7A11 GeneProduct ensembl:ENSBTAG00000034075 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000151012

References

  1. Cancer chemoprevention with dietary phytochemicals. Surh YJ. Nat Rev Cancer. 2003 Oct;3(10):768–80. PubMed Europe PMC Scholia