G1 to S cell cycle control (WP959)

Pan troglodytes

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In the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding CKIs mediated by the p53 protein, whereas the p53-independent mechanisms inhibit CDKs through the inhibitory T14Y15 phosphorylation of Cdk2. Failure of DNA damage checkpoints in G1 leads to mutagenic replication of damaged templates and other replication defects. Source: Reactome http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&FOCUS_SPECIES=Homo%20sapiens&ID=69615&

Authors

Kristina Hanspers , Christine Chichester , and Martina Summer-Kutmon

Activity

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Organisms

Pan troglodytes

Communities

Annotations

Pathway Ontology

cell cycle checkpoint pathway G1/S DNA damage checkpoint pathway

Participants

Label Type Compact URI Comment
RB1 GeneProduct ensembl:ENSPTRG00000005864 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5925
E2F2 GeneProduct ensembl:ENSPTRG00000000330 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1870
E2F1 GeneProduct ensembl:ENSPTRG00000013404 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1869
POLE GeneProduct ensembl:ENSPTRG00000045365 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5426
CDKN1B GeneProduct ensembl:ENSPTRG00000004707 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1027
CDK6 GeneProduct ensembl:ENSPTRG00000019400 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1021
PCNA GeneProduct ensembl:ENSPTRG00000013222 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5111
CDK4 GeneProduct ensembl:ENSPTRG00000005147 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1019
CDKN1A GeneProduct ensembl:ENSPTRG00000018107 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1026
CDC45 GeneProduct ensembl:ENSPTRG00000014064 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:8318
CDK1 GeneProduct ensembl:ENSPTRG00000002528 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:983
TP53 GeneProduct ensembl:ENSPTRG00000008703 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:7157
PRIM2A GeneProduct ensembl:ENSPTRG00000044256 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5558
CDKN1C GeneProduct ensembl:ENSPTRG00000003182 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1028
CCND2 GeneProduct ensembl:ENSPTRG00000004549 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:894
E2F5 GeneProduct ensembl:ENSPTRG00000020384 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1875
CCNE1 GeneProduct ensembl:ENSPTRG00000010782 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:898
CREB3L4 GeneProduct ensembl:ENSPTRG00000001368 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:148327
CDKN2B GeneProduct ensembl:ENSPTRG00000049465 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1030
MDM2 GeneProduct ensembl:ENSPTRG00000005203 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4193
CDK7 GeneProduct ensembl:ENSPTRG00000016946 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1022
CCNG2 GeneProduct ensembl:ENSPTRG00000016196 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:901
RPA2 GeneProduct ensembl:ENSPTRG00000000420 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:6118
CDK2 GeneProduct ensembl:ENSPTRG00000005070 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1017
E2F4 GeneProduct ensembl:ENSPTRG00000031180 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1874
CDKN2D GeneProduct ensembl:ENSPTRG00000010477 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1032
CREB3 GeneProduct ensembl:ENSPTRG00000020918 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:10488
CREB3L3 GeneProduct ensembl:ENSPTRG00000010295 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:84699
MYT1 GeneProduct ensembl:ENSPTRG00000032477 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4661
TFDP2 GeneProduct ensembl:ENSPTRG00000015479 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:7029
CCNB1 GeneProduct ensembl:ENSPTRG00000016942 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:891
CCND3 GeneProduct ensembl:ENSPTRG00000018164 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:896
CCND1 GeneProduct ensembl:ENSPTRG00000052519 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:595
CCNH GeneProduct ensembl:ENSPTRG00000017063 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:902
MYC GeneProduct ensembl:ENSPTRG00000020581 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4609
RPA3 GeneProduct ensembl:ENSPTRG00000018927 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:6119
MCM4 GeneProduct ensembl:ENSPTRG00000020230 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4173
MCM3 GeneProduct ensembl:ENSPTRG00000018275 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4172
CREBL1 GeneProduct ensembl:ENSPTRG00000043301 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1388
ORC1 GeneProduct ensembl:ENSPTRG00000000738 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4998
MCM6 GeneProduct ensembl:ENSPTRG00000012498 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4175
MCM7 GeneProduct ensembl:ENSPTRG00000019472 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4176
MCM2 GeneProduct ensembl:ENSPTRG00000015345 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4171
ORC3 GeneProduct ensembl:ENSPTRG00000018408 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:23595
CDKN2C GeneProduct ensembl:ENSPTRG00000000726 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1031
POLE2 GeneProduct ensembl:ENSPTRG00000048697 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5427
MNAT1 GeneProduct ensembl:ENSPTRG00000006412 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4331
ORC6 GeneProduct ensembl:ENSPTRG00000008080 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:23594
MCM5 GeneProduct ensembl:ENSPTRG00000014299 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4174
E2F6 GeneProduct ensembl:ENSPTRG00000011661 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1876
ORC2 GeneProduct ensembl:ENSPTRG00000012795 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4999
E2F3 GeneProduct ensembl:ENSPTRG00000023584 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1871
TFDP1 GeneProduct ensembl:ENSPTRG00000048704 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:7027
RPA1 GeneProduct ensembl:ENSPTRG00000008539 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:6117
CREB1 GeneProduct ensembl:ENSPTRG00000043959 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1385
RBL1 GeneProduct ensembl:ENSPTRG00000013469 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5933
WEE1 GeneProduct ensembl:ENSPTRG00000003350 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:7465
ATM GeneProduct ensembl:ENSPTRG00000004250 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:472
CREB3L1 GeneProduct ensembl:ENSPTRG00000003543 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:90993
GADD45A GeneProduct ensembl:ENSPTRG00000000842 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1647
POLA2 GeneProduct ensembl:ENSPTRG00000003870 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:23649
ORC4 GeneProduct ensembl:ENSPTRG00000012515 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5000
PRIM1 GeneProduct ensembl:ENSPTRG00000022987 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5557
CDC25A GeneProduct ensembl:ENSPTRG00000014879 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:993
CCNA1 GeneProduct ensembl:ENSPTRG00000005784 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:8900
ORC5 GeneProduct ensembl:ENSPTRG00000019561 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5001
CCNE2 GeneProduct ensembl:ENSPTRG00000020433 Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:9134

References

  1. GADD45 regulates G2/M arrest, DNA repair, and cell death in keratinocytes following ultraviolet exposure. Maeda T, Hanna AN, Sim AB, Chua PP, Chong MT, Tron VA. J Invest Dermatol. 2002 Jul;119(1):22–6. PubMed Europe PMC Scholia