Monoamine GPCRs (WP839)

Gallus gallus

G protein–coupled receptors (GPCRs) which are also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses. Coupling with G proteins, they are called seven-transmembrane receptors because they pass through the cell membrane seven times. Source: [https://en.wikipedia.org/wiki/G_protein–coupled_receptor Wikipedia] Monoamine GPCRs are Rhodopsin-like GPCRs that bind to monoamine neurotransmitters. [https://en.wikipedia.org/wiki/Monoamine_neurotransmitter Monoamine neurotransmitters]

Authors

Egon Willighagen , Kristina Hanspers , and Martina Summer-Kutmon

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Gallus gallus

Communities

Annotations

Pathway Ontology

G protein mediated signaling pathway

Participants

Label Type Compact URI Comment
Serotonin Metabolite chebi:28790
Epinephrine Metabolite hmdb:HMDB0000068
Norepinephrine Metabolite hmdb:HMDB0000216
Acetylcholine Metabolite hmdb:HMDB0000895
Muscarine Metabolite pubchem.substance:9676
Histamine Metabolite chebi:18295
Dopamine Metabolite chebi:18243
ADRA2C GeneProduct ncbigene:428799
HTR4 GeneProduct ncbigene:416150
DRD3 GeneProduct ncbigene:770757
HRH2 GeneProduct ncbigene:427635
CHRM3 GeneProduct ncbigene:396364
ADRA1A GeneProduct ncbigene:428203
DRD5 GeneProduct ncbigene:428795
DRD4 GeneProduct ncbigene:423016
ADRA1B GeneProduct ncbigene:373890
CHRM2 GeneProduct ncbigene:418126
HTR6 GeneProduct ncbigene:430019
HTR1D GeneProduct ncbigene:769107
HTR1E GeneProduct ncbigene:771973
HTR7 GeneProduct ncbigene:423794
CHRM4 GeneProduct ncbigene:423195
DRD2 GeneProduct ncbigene:428252
CHRM5 GeneProduct ncbigene:428881
ADRA2A GeneProduct ncbigene:428980
HTR2A GeneProduct ncbigene:428070
HTR1F GeneProduct ncbigene:427963
DRD1 GeneProduct ncbigene:427633
HTR5A GeneProduct ncbigene:428409
ADRB1 GeneProduct ncbigene:430991
ADRA2B GeneProduct ncbigene:427631
HTR2C GeneProduct ncbigene:428707
HTR2B GeneProduct ncbigene:395581
HTR1A GeneProduct ncbigene:431581
ADRA1D GeneProduct ncbigene:422933
HTR1B GeneProduct ncbigene:421858
ADRB2 GeneProduct ncbigene:427623

References