Integrin-mediated cell adhesion (WP74)

Rattus norvegicus

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Integrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and thereby define cellular shape, mobility, and regulate the cell cycle. Source: Wikipedia

Authors

Thomas Kelder , Daniela Digles , Lauren J. Dupuis , and Kristina Hanspers

Activity

last edited pathway curation

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Cited In

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Organisms

Rattus norvegicus

Communities

Annotations

Pathway Ontology

integrin mediated signaling pathway

Participants

Label Type Compact URI Comment
Itga4 GeneProduct ncbigene:311144
Capn9 GeneProduct ncbigene:116694 CAPN9; calpain 9 (nCL-4) [EC:3.4.22.17
Ilk GeneProduct ncbigene:170922 ILK; integrin-linked kinase [EC:2.7.1.-]
Ptk2 GeneProduct ncbigene:25614 PTK2; PTK2 protein tyrosine kinase 2 [EC:2.7.1.112
ITGB3 GeneProduct ncbigene:29302
ITGAE GeneProduct ncbigene:83577
Sos1 GeneProduct ncbigene:313845 SOS1; son of sevenless homolog 1 (Drosophila)
Zyx GeneProduct ncbigene:114636 ZYX; zyxin
Rap1a GeneProduct ncbigene:295347 RAP1A; RAP1A member of RAS oncogene family
Itgam GeneProduct ncbigene:25021
Crk GeneProduct ncbigene:54245 CRK; v-crk sarcoma virus CT10 oncogene homolog (avian
Itga7 GeneProduct ncbigene:81008
Itgb7 GeneProduct ncbigene:25713
Capn5 GeneProduct ncbigene:171495 CAPN5; calpain
Itgad GeneProduct ncbigene:64350
Sepp1 GeneProduct ncbigene:29360 SEPP1; selenoprotein P plasma
Rock1 GeneProduct ncbigene:81762 ROCK1; Rho-associated coiled-coil containing protein kinase
Itgav GeneProduct ncbigene:296456
Itga3 GeneProduct ncbigene:360606
Vcl GeneProduct ncbigene:305679 VCL; vinculin
RAPGEF1 GeneProduct ncbigene:63881 GRF2; guanine nucleotide-releasing factor 2 (specific for crk proto-oncogene
LOC685269 GeneProduct ncbigene:685269
Capn6 GeneProduct ncbigene:83685 CAPN6; calpain 6 [EC:3.4.22.17]
Rac2 GeneProduct ncbigene:366957 RAC2; ras-related C3 botulinum toxin substrate 2 (rho family small GTP binding protein Rac2)
Pxn GeneProduct ncbigene:360820 PXN; paxillin
Pak6 GeneProduct ncbigene:296078 PAK6; p21(CDKN1A)-activated kinase
Map2k1 GeneProduct ncbigene:170851 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.1.-]
Bcar1 GeneProduct ncbigene:25414 BCAR1; breast cancer anti-estrogen resistance 1
Itgb4 GeneProduct ncbigene:25724
Itgb8 GeneProduct ncbigene:362800
Pdpk1 GeneProduct ncbigene:81745 PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.1.37]
Capn3 GeneProduct ncbigene:29155 CAPN3; calpain 3 (p94) [EC:3.4.22.17]
Src GeneProduct ncbigene:83805 SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:2.7.1.112]
Dock1 GeneProduct ncbigene:309081 DOCK1; dedicator of cyto-kinesis
Vav3 GeneProduct ncbigene:295378 VAV3; vav 3 oncogene
Braf GeneProduct ncbigene:114486 BRAF; v-raf murine sarcoma viral oncogene homolog B1 [EC:2.7.1.-]
Cav2 GeneProduct ncbigene:363425 CAV2; caveolin 2
Itgal GeneProduct ncbigene:308995
Araf GeneProduct ncbigene:64363 ARAF1; v-raf murine sarcoma 3611 viral oncogene homolog 1 [EC:2.7.1.-]
Capn11 GeneProduct ncbigene:408218 CAPN11; calpain 11 [EC:3.4.22.17]
CAPN10 GeneProduct ncbigene:63834 CAPN10; calpain 10 [EC:3.4.22.17
Itgax GeneProduct ncbigene:499271
Itga1 GeneProduct ncbigene:25118
Fyn GeneProduct ncbigene:25150 FYN; FYN oncogene related to SRC FGR YES [EC:2.7.1.112]
Mapk10 GeneProduct ncbigene:25272
Csk GeneProduct ncbigene:315707 CSK; c-src tyrosine kinase [EC:2.7.1.112]
Cav3 GeneProduct ncbigene:29161 CAV3; caveolin 3
Rho GeneProduct ncbigene:24717 RHO; rhodopsin (opsin 2 rod pigment) (retinitis pigmentosa 4 autosomal dominant)
Hras GeneProduct ncbigene:293621
MAPK7 GeneProduct ncbigene:114509 MAPK7; mitogen-activated protein kinase 7 [EC:2.7.1.-
Cav1 GeneProduct ncbigene:25404 CAV1; caveolin 1 caveolae protein 22kD
Itgb6 GeneProduct ncbigene:311061
Mapk6 GeneProduct ncbigene:58840 MAPK6; mitogen-activated protein kinase 6 [EC:2.7.1.-]
Shc1 GeneProduct ncbigene:85385 SHC1; SHC (Src homology 2 domain containing) transforming protein 1
Itgb1 GeneProduct ncbigene:24511
Capn2 GeneProduct ncbigene:29154 CAPN2; calpain 2 (m/II) large subunit [EC:3.4.22.17]
Akt3 GeneProduct ncbigene:29414 AKT3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B gamma) [EC:2.7.1.-]
Map2k2 GeneProduct ncbigene:58960 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.1.-]
Pik3r2 GeneProduct ncbigene:29741 PIK3R2; phosphoinositide-3-kinase regulatory subunit polypeptide 2 (p85 beta)
Itga9 GeneProduct ncbigene:685004
Tns1 GeneProduct ncbigene:301509 TNS; tensi
Capn7 GeneProduct ncbigene:306260 CAPN7; calpain 7 [EC:3.4.22.17
Itga5 GeneProduct ncbigene:315346
Itga10 GeneProduct ncbigene:310683
Raf1 GeneProduct ncbigene:24703 RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 [EC:2.7.1.-]
Vav2 GeneProduct ncbigene:296603 VAV2; vav 2 oncogene
CDC42 GeneProduct ncbigene:64465 CDC42; cell division cycle 42 (GTP binding protein 25kD)
Map2k5 GeneProduct ncbigene:29568 MAP2K5; mitogen-activated protein kinase kinase 5 [EC:2.7.1.-]
Capns1 GeneProduct ncbigene:29156 CAPNS1; calpain small subunit 1 [EC:3.4.22.17]
Itgb2 GeneProduct ncbigene:309684
Pak2 GeneProduct ncbigene:29432 PAK2; p21 (CDKN1A)-activated kinase 2 [EC:2.7.1.-]
Map2k3 GeneProduct ncbigene:303200 MAP2K3; mitogen-activated protein kinase kinase 3 [EC:2.7.1.-]
Mapk1 GeneProduct ncbigene:116590 MAPK1; mitogen-activated protein kinase 1 [EC:2.7.1.-]
Sorbs1 GeneProduct ncbigene:686098 SH3D5; SH3-domain protein 5 (ponsin
Rap1b GeneProduct ncbigene:171337 RAP1B; RAP1B member of RAS oncogene family
Map2k6 GeneProduct ncbigene:114495 MAP2K6; mitogen-activated protein kinase kinase 6 [EC:2.7.1.-
Pak3 GeneProduct ncbigene:29433 PAK3; p21 (CDKN1A)-activated kinase 3 [EC:2.7.1.-]
Itga2 GeneProduct ncbigene:170921
Akt2 GeneProduct ncbigene:25233 AKT2; v-akt murine thymoma viral oncogene homolog 2 [EC:2.7.1.-]
Capn1 GeneProduct ncbigene:29153 CAPN1; calpain 1 (mu/I) large subunit [EC:3.4.22.17]
Rac1 GeneProduct ncbigene:363875 RAC1; ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein Rac1)
Rock2 GeneProduct ncbigene:25537 ROCK2; Rho-associated coiled-coil containing protein kinase
Git2 GeneProduct ncbigene:304546 GIT2; G protein-coupled receptor kinase-interactor 2
Vasp GeneProduct ncbigene:361517 VASP; vasodilator-stimulated phosphoprotein
Itga6 GeneProduct ncbigene:114517
Pak1 GeneProduct ncbigene:29431 PAK1; p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog yeast) [EC:2.7.1.-]
Akt1 GeneProduct ncbigene:24185 AKT1; v-akt murine thymoma viral oncogene homolog 1 [EC:2.7.1.-]
Grb2 GeneProduct ncbigene:81504 GRB2; growth factor receptor-bound protein 2
ITGB5 GeneProduct ncbigene:257645
RGD1564327 GeneProduct ncbigene:364786
Itga11 GeneProduct ncbigene:315744
Arhgef7 GeneProduct ncbigene:114559 ARHGEF7; Rho guanine nucleotide exchange factor (GEF) 7
Mylk2 GeneProduct ncbigene:117558 MYLK2; myosin light chain kinase 2 skeletal muscle [EC:2.7.1.117
Pak4 GeneProduct ncbigene:292756 PAK4; p21(CDKN1A)-activated kinase 4 [EC:2.7.1.-]
Mapk4 GeneProduct ncbigene:54268 MAPK4; mitogen-activated protein kinase 4 [EC:2.7.1.-]
Mapk12 GeneProduct ncbigene:60352 MAPK12; mitogen-activated protein kinase 12 [EC:2.7.1.-]
Tln1 GeneProduct ncbigene:313494 TLN1; talin 1
Shc3 GeneProduct ncbigene:114858 SHC3; neuronal Sh

References

  1. Assembly and signaling of adhesion complexes. Sepulveda JL, Gkretsi V, Wu C. Curr Top Dev Biol. 2005;68:183–225. PubMed Europe PMC Scholia