Calcium regulation in cardiac cells (WP553)

Mus musculus

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Calcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resulting from activation of ion channels or as a second messenger caused by indirect signal transduction pathways such as G protein-coupled receptors. Movement of calcium ions from the extracellular compartment to the intracellular compartment alters membrane depolarisation. This is seen in the heart, during the plateau phase of ventricular contraction. In this example, calcium acts to maintain depolarisation of the heart. Source: [[wikipedia:Calcium_signaling|Wikipedia]]

Authors

Nathan Salomonis , Joanna Fong , Nathalie Cotte , Thomas Kelder , Kristina Hanspers , Christine Chichester , Egon Willighagen , Sian Yun Ang , Martina Summer-Kutmon , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Mus musculus

Communities

Annotations

Cell Type Ontology

cardiac muscle cell

Pathway Ontology

calcium/calcium-mediated signaling pathway

Disease Ontology

cardiovascular system disease

Participants

Label Type Compact URI Comment
ATP Metabolite cas:1927-31-7
Epinephrine Metabolite hmdb:HMDB0000068
Na+ Metabolite hmdb:HMDB0000588
Acetylcholine Metabolite cas:51-84-3
Pi Metabolite hmdb:HMDB0001429
IP4 Metabolite chebi:16783
IP3 Metabolite chemspider:388562
ADP Metabolite cas:58-64-0
K+ Metabolite hmdb:HMDB0000586
Ca2+ Metabolite hmdb:HMDB0000464
cAMP Metabolite pubchem.compound:6076
PIP2 Metabolite hmdb:HMDB0010032
ADP Metabolite hmdb:HMDB0001341
Cacnb1 GeneProduct ensembl:ENSMUSG00000020882 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:782
Camk2g GeneProduct ensembl:ENSMUSG00000021820 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:818
Ryr2 GeneProduct ensembl:ENSMUSG00000021313 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6262
Rgs6 GeneProduct ensembl:ENSMUSG00000021219 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:9628
Adcy4 GeneProduct ensembl:ENSMUSG00000022220 There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:196883
Gng2 GeneProduct ensembl:ENSMUSG00000043004 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:54331
Adcy1 GeneProduct ensembl:ENSMUSG00000020431 CYA1 HUMAN
Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:107
Camk2a GeneProduct ensembl:ENSMUSG00000024617 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:815
Prkcb GeneProduct ensembl:ENSMUSG00000052889 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5579
Cacna1e GeneProduct ensembl:ENSMUSG00000004110 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:777
Gng13 GeneProduct ensembl:ENSMUSG00000025739 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:51764
Rgs1 GeneProduct ensembl:ENSMUSG00000026358 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5996
Atp2b1 GeneProduct ensembl:ENSMUSG00000019943 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:490
Gnai2 GeneProduct ensembl:ENSMUSG00000032562 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2771
Atp2a3 GeneProduct ensembl:ENSMUSG00000020788 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:489
Atp2b3 GeneProduct ensembl:ENSMUSG00000031376 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:492
Gja5 GeneProduct ensembl:ENSMUSG00000057123 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2702
Plcb3 GeneProduct ensembl:ENSMUSG00000024960 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5331
Adra1a GeneProduct ensembl:ENSMUSG00000045875 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:148
Gnb4 GeneProduct ensembl:ENSMUSG00000027669 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:59345
Pln GeneProduct ensembl:ENSMUSG00000038583 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5350
Rgs20 GeneProduct ensembl:ENSMUSG00000002459 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8601
Prkacb GeneProduct ensembl:ENSMUSG00000005034 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5567
Ryr1 GeneProduct ensembl:ENSMUSG00000030592 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6261
Camk4 GeneProduct ensembl:ENSMUSG00000038128 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:814
Adcy5 GeneProduct ensembl:ENSMUSG00000022840 There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:111
Pkib GeneProduct ensembl:ENSMUSG00000019876 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5570
Arrb2 GeneProduct ensembl:ENSMUSG00000060216 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:409
Rgs10 GeneProduct ensembl:ENSMUSG00000030844 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6001
Adra1d GeneProduct ensembl:ENSMUSG00000027335 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:146
Adrb1 GeneProduct ensembl:ENSMUSG00000035283 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:153
Rgs14 GeneProduct ensembl:ENSMUSG00000052087 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:10636
Cacna1s GeneProduct ensembl:ENSMUSG00000026407 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:779
Chrm4 GeneProduct ensembl:ENSMUSG00000040495 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1132
Chrm2 GeneProduct ensembl:ENSMUSG00000045613 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1129
Cacna1c GeneProduct ensembl:ENSMUSG00000051331 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:775
Gjc1 GeneProduct ensembl:ENSMUSG00000034520 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:10052
Kcnb1 GeneProduct ensembl:ENSMUSG00000050556 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3745
Adcy2 GeneProduct ensembl:ENSMUSG00000021536 There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:108
Gja1 GeneProduct ensembl:ENSMUSG00000050953 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2697
Itpr2 GeneProduct ensembl:ENSMUSG00000030287 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3709
Prkar1b GeneProduct ensembl:ENSMUSG00000025855 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5575
Cacna1d GeneProduct ensembl:ENSMUSG00000015968 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:776
Camk2d GeneProduct ensembl:ENSMUSG00000053819 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:817
Gnb3 GeneProduct ensembl:ENSMUSG00000023439 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2784
Cacna1a GeneProduct ensembl:ENSMUSG00000034656 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:773
Kcnj3 GeneProduct ensembl:ENSMUSG00000026824 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3760
Rgs5 GeneProduct ensembl:ENSMUSG00000026678 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8490
Ywhab GeneProduct ensembl:ENSMUSG00000018326 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7529
Gnb5 GeneProduct ensembl:ENSMUSG00000032192 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:10681
Kcnj5 GeneProduct ensembl:ENSMUSG00000032034 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3762
Ywhaz GeneProduct ensembl:ENSMUSG00000022285 PMID: 9861170 PMID: 1317796
Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7534
Ywhah GeneProduct ensembl:ENSMUSG00000018965 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7533
Gja3 GeneProduct ensembl:ENSMUSG00000048582 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2700
Itpr1 GeneProduct ensembl:ENSMUSG00000030102 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3708
Atp2b2 GeneProduct ensembl:ENSMUSG00000030302 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:491
Gjb3 GeneProduct ensembl:ENSMUSG00000042367 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2707
Gjb4 GeneProduct ensembl:ENSMUSG00000046623 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:127534
Sfn GeneProduct ensembl:ENSMUSG00000047281 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2810
Prkd1 GeneProduct ensembl:ENSMUSG00000002688 KPCM HUMAN
Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5587
Gng12 GeneProduct ensembl:ENSMUSG00000036402 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:55970
Gnaq GeneProduct ensembl:ENSMUSG00000024639 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2776
Gng11 GeneProduct ensembl:ENSMUSG00000032766 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2791
Prkcd GeneProduct ensembl:ENSMUSG00000021948 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5580
Gng7 GeneProduct ensembl:ENSMUSG00000048240 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2788
Gjb6 GeneProduct ensembl:ENSMUSG00000040055 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:10804
Gnai3 GeneProduct ensembl:ENSMUSG00000000001 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2773
Prkce GeneProduct ensembl:ENSMUSG00000045038 This EST is listed on the Affymetrix Murine6500 chip. The SwissProt entry name is KPCE MOUSE.
Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5581
Rgs18 GeneProduct ensembl:ENSMUSG00000026357 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:64407
Rgs7 GeneProduct ensembl:ENSMUSG00000026527 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6000
Grk5 GeneProduct ensembl:ENSMUSG00000003228 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2869
Gng8 GeneProduct ensembl:ENSMUSG00000063594 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:94235
Pkia GeneProduct ensembl:ENSMUSG00000027499 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5569
Ryr3 GeneProduct ensembl:ENSMUSG00000057378 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6263
Itpr3 GeneProduct ensembl:ENSMUSG00000042644 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3710
Adcy8 GeneProduct ensembl:ENSMUSG00000022376 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:114
Chrm1 GeneProduct ensembl:ENSMUSG00000032773 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1128
Rgs19 GeneProduct ensembl:ENSMUSG00000002458 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:10287
Adra1b GeneProduct ensembl:ENSMUSG00000050541 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:147
Calm3 GeneProduct ensembl:ENSMUSG00000019370 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:808
Fkbp1a GeneProduct ensembl:ENSMUSG00000032966 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2280
Gjb1 GeneProduct ensembl:ENSMUSG00000047797 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2705
Gja8 GeneProduct ensembl:ENSMUSG00000049908 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2703
Rgs17 GeneProduct ensembl:ENSMUSG00000019775 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:26575
Casq1 GeneProduct ensembl:ENSMUSG00000007122 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:844
Adcy3 GeneProduct ensembl:ENSMUSG00000020654 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:109
Ywhae GeneProduct ensembl:ENSMUSG00000020849 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7531
Anxa6 GeneProduct ensembl:ENSMUSG00000018340 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:309
Gna11 GeneProduct ensembl:ENSMUSG00000034781 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2767
Gng5 GeneProduct ensembl:ENSMUSG00000068523 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2787
Adcy9 GeneProduct ensembl:ENSMUSG00000005580 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:115
Rgs16 GeneProduct ensembl:ENSMUSG00000026475 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6004
Slc8a1 GeneProduct ensembl:ENSMUSG00000054640 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6546
Ywhaq GeneProduct ensembl:ENSMUSG00000076432 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:10971
Adcy7 GeneProduct ensembl:ENSMUSG00000031659 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:113
Gnaz GeneProduct ensembl:ENSMUSG00000040009 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2781
Adrb3 GeneProduct ensembl:ENSMUSG00000031489 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:155
Gjb5 GeneProduct ensembl:ENSMUSG00000042357 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2709
Calr GeneProduct ensembl:ENSMUSG00000003814 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:811
Rgs11 GeneProduct ensembl:ENSMUSG00000024186 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8786
Gngt1 GeneProduct ensembl:ENSMUSG00000029663 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2792
Prkcz GeneProduct ensembl:ENSMUSG00000029053 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5590
Prkar1a GeneProduct ensembl:ENSMUSG00000020612 KAP0 HUMAN
Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5573
Gnb2 GeneProduct ensembl:ENSMUSG00000029713 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2783
Pkig GeneProduct ensembl:ENSMUSG00000035268 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:11142
Rgs4 GeneProduct ensembl:ENSMUSG00000038530 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5999
Prkch GeneProduct ensembl:ENSMUSG00000021108 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5583
Prkar2b GeneProduct ensembl:ENSMUSG00000002997 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5577
Prkcq GeneProduct ensembl:ENSMUSG00000026778 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5588
Gng3 GeneProduct ensembl:ENSMUSG00000071658 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2785
Prkca GeneProduct ensembl:ENSMUSG00000050965 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5578
Gjc2 GeneProduct ensembl:ENSMUSG00000043448 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:57165
Gnb1 GeneProduct ensembl:ENSMUSG00000029064 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2782
Casq2 GeneProduct ensembl:ENSMUSG00000027861 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:845
Gnao1 GeneProduct ensembl:ENSMUSG00000031748 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2775
Slc8a3 GeneProduct ensembl:ENSMUSG00000079055 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6547
Pln GeneProduct ensembl:ENSMUSG00000038583 Homology Mapping from Homo sapiens to Mus musculus: Original ID = En:ENSG00000198523
Atp2a2 GeneProduct ensembl:ENSMUSG00000029467 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:488
Rgs2 GeneProduct ensembl:ENSMUSG00000026360 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5997
Arrb1 GeneProduct ensembl:ENSMUSG00000018909 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:408
Gnas GeneProduct ensembl:ENSMUSG00000027523 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2778
Gjb2 GeneProduct ensembl:ENSMUSG00000046352 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2706
Cacna1b GeneProduct ensembl:ENSMUSG00000004113 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:774
Gnai1 GeneProduct ensembl:ENSMUSG00000057614 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2770
Chrm3 GeneProduct ensembl:ENSMUSG00000046159 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1131
Rgs9 GeneProduct ensembl:ENSMUSG00000020599 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8787
Chrm5 GeneProduct ensembl:ENSMUSG00000074939 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1133
Camk2b GeneProduct ensembl:ENSMUSG00000057897 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:816
Gja4 GeneProduct ensembl:ENSMUSG00000050234 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2701
Gng4 GeneProduct ensembl:ENSMUSG00000021303 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2786
Ywhag GeneProduct ensembl:ENSMUSG00000051391 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7532
Camk1 GeneProduct ensembl:ENSMUSG00000030272 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8536
Cacnb3 GeneProduct ensembl:ENSMUSG00000003352 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:784
Prkcg GeneProduct ensembl:ENSMUSG00000078816 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5582
Adcy6 GeneProduct ensembl:ENSMUSG00000022994 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:112
Grk4 GeneProduct ensembl:ENSMUSG00000052783 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2868
Prkar2a GeneProduct ensembl:ENSMUSG00000032601 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5576
Adrb2 GeneProduct ensembl:ENSMUSG00000045730 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:154
Rgs3 GeneProduct ensembl:ENSMUSG00000059810 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5998
Gjd2 GeneProduct ensembl:ENSMUSG00000068615 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:57369
Grk6 GeneProduct ensembl:ENSMUSG00000074886 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2870
Atp1a4 GeneProduct ensembl:ENSMUSG00000007107 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:480
Atp1b1 GeneProduct ensembl:ENSMUSG00000026576 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:481
Fxyd2 GeneProduct ensembl:ENSMUSG00000059412 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:486
Atp1b2 GeneProduct ensembl:ENSMUSG00000041329 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:482
Atp1b3 GeneProduct ensembl:ENSMUSG00000032412 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:483

References

  1. Calcium and the heart: a question of life and death. Marks AR. J Clin Invest. 2003 Mar;111(5):597–600. PubMed Europe PMC Scholia