GIP and GLP-1 function by tissue (WP5509)

Homo sapiens

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Functions of GIP and GLP-1, two agonists of which are found in the weight-loss drug tirzepatide (a.k.a. Mounjaro). "Pancreatic and exopancreatic function of glucose‐dependent insulinotropic polypepide (GIP) and glucagon‐like peptide (GLP)‐1. GIP acts directly on the endocrine pancreas, bone, fat, gastrointestinal (GI) tract and brain. GLP‐1 acts directly on the endocrine pancreas, gastrointestinal tract, heart and brain." From Figure 2 in https://pmc.ncbi.nlm.nih.gov/articles/PMC4020673/.

Authors

Eric Weitz and Egon Willighagen

Activity

last edited

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Organisms

Homo sapiens

Communities

Annotations

Cell Type Ontology

intestinal epithelial cell type B pancreatic cell neuron

Participants
Query Drugst.One

Label Type Compact URI Comment
Insulin Metabolite chebi:5931
Glucagon Metabolite chebi:5391
GIP GeneProduct ensembl:ENSG00000159224
GLP-1 GeneProduct ensembl:ENSG00000115263
GCG GeneProduct ensembl:ENSG00000115263

References

  1. GIP and GLP-1, the two incretin hormones: Similarities and differences. Seino Y, Fukushima M, Yabe D. J Diabetes Investig. 2010 Apr 22;1(1–2):8–23. PubMed Europe PMC Scholia