Rotenone metabolism (WP5486)

Homo sapiens

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Human metabolism of rotenone is mostly happening because of the CYP3A4 and CYP2C19 enzymes, resulting in two 12a-hydroxyrotenone isomers (rotenolone I and rotenolone II) and 8′-hydroxyrotenone.

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Authors

Egon Willighagen

Activity

last edited

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

xenobiotic metabolic pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
rotenone Metabolite wikidata:Q412388
rotenolone I Metabolite pubchem.compound:68184
8′-hydroxyrotenone Metabolite pubchem.compound:92207
rotenolone II Metabolite pubchem.compound:99189
CYP3A4 GeneProduct ensembl:ENSG00000160868
CYP2C19 GeneProduct ensembl:ENSG00000165841

References

  1. Oxidative metabolism of rotenone in mammals, fish, and insects and its relation to selective toxicity. Fukami J, Shishido T, Fukunaga K, Casida JE. J Agric Food Chem [Internet]. 1969 Nov;17(6):1217–26. Available from: http://dx.doi.org/10.1021/jf60166a048 DOI Scholia
  2. Metabolism of rotenone in vitro by tissue homogenates from mammals and insects. Fukami JI, Yamamoto I, Casida JE. Science. 1967 Feb 10;155(3763):713–6. PubMed Europe PMC Scholia
  3. Rotenone, deguelin, their metabolites, and the rat model of Parkinson’s disease. Caboni P, Sherer TB, Zhang N, Taylor G, Na HM, Greenamyre JT, et al. Chem Res Toxicol. 2004 Nov;17(11):1540–8. PubMed Europe PMC Scholia
  4. Using Rotenone to Model Parkinson’s Disease in Mice: A Review of the Role of Pharmacokinetics. Innos J, Hickey MA. Chem Res Toxicol. 2021 May 17;34(5):1223–39. PubMed Europe PMC Scholia