GLP-1 in pancreatic islet cells (WP5447)

Homo sapiens

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Factors in GLP-1 production in pancreatic alpha cells, and the hypothetical function of resulting GLP-1 in pancreatic beta cells. Glucagon-like peptide-1 (GLP-1) is a short protein that suppresses feeding and helps manage glucose levels in diabetes. It is encoded by the GCG gene. Based on Figure 3 in https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9190119.

Authors

Eric Weitz and Egon Willighagen

Activity

last edited

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Organisms

Homo sapiens

Communities

Annotations

Cell Type Ontology

insulin secreting cell type B pancreatic cell pancreatic A cell

Pathway Ontology

insulin secretion pathway signaling pathway glucagon-like peptide-1 biosynthetic pathway facilitative sugar transporter mediated glucose transport pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
Glucose Metabolite chebi:17234
GLP1R GeneProduct ensembl:ENSG00000112164
GCG GeneProduct ensembl:ENSG00000115263
IL6 GeneProduct ensembl:ENSG00000136244
IL6R GeneProduct ensembl:ENSG00000160712
SLC2A1 GeneProduct ensembl:ENSG00000117394
SLC2A2 GeneProduct ensembl:ENSG00000163581
INS GeneProduct ensembl:ENSG00000254647
GLP-1 Protein wikidata:Q424611
Insulin Protein uniprot:P01308

References

  1. Glucagon-Like Peptide-1: Actions and Influence on Pancreatic Hormone Function. Davis EM, Sandoval DA. Compr Physiol. 2020 Mar 12;10(2):577–95. PubMed Europe PMC Scholia