De novo NAD biosynthesis (WP541)
Saccharomyces cerevisiae
Most organisms synthesize NAD+ from simple components. The specific set of reactions differs among organisms, but a common feature is the generation of quinolinic acid (QA) from an amino acid – either tryptophan (Trp) in animals and some bacteria, or aspartic acid (Asp) in some bacteria and plants. The quinolinic acid is converted to nicotinic acid mononucleotide (NaMN) by transfer of a phosphoribose moiety. An adenylate moiety is then transferred to form nicotinic acid adenine dinucleotide (NaAD). Finally, the nicotinic acid moiety in NaAD is amidated to a nicotinamide (Nam) moiety, forming nicotinamide adenine dinucleotide. Description adapted from [https://en.wikipedia.org/wiki/Nicotinamide_adenine_dinucleotide Wikipedia].
Authors
Meredith Braymer , Christine Chichester , Egon Willighagen , Kristina Hanspers , and Eric WeitzActivity
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Organisms
Saccharomyces cerevisiaeCommunities
Annotations
Pathway Ontology
classic metabolic pathway de novo nicotinamide adenine dinucleotide biosynthetic pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| L-Formylkynurenine | Metabolite | cas:1022-31-7 | |
| ATP | Metabolite | cas:1927-31-7 | |
| AMP | Metabolite | chebi:16027 | |
| L-alanine | Metabolite | chebi:16977 | |
| CO2 | Metabolite | chebi:16526 | |
| H2O | Metabolite | hmdb:HMDB02111 | |
| pyrophosphate | Metabolite | cas:2466-09-3 | |
| 2-Amino-3-carboxymuconate semialdehyde | Metabolite | chebi:995 | |
| L-glutamine | Metabolite | cas:56-85-9 | |
| 3-hydroxyanthranilate | Metabolite | chebi:36559 | |
| formate | Metabolite | chebi:15740 | |
| NADP | Metabolite | chebi:44409 | |
| NADPH | Metabolite | cas:53-57-6 | |
| PRPP | Metabolite | cas:97-55-2 | |
| kynurenine | Metabolite | cas:343-65-7 | |
| quinolinate | Metabolite | chebi:29959 | |
| NAD | Metabolite | chebi:16908 | |
| O2 | Metabolite | chebi:25805 | |
| L-tryptophan | Metabolite | cas:73-22-3 | |
| L-glutamate | Metabolite | cas:56-86-0 | |
| deamido-NAD | Metabolite | wikidata:Q28529688 | |
| 3-hydroxy-L-kynurenine | Metabolite | cas:606-14-4 | |
| BNA6 | GeneProduct | sgd:S000001943 | |
| NMA2 | GeneProduct | sgd:S000003242 | |
| BNA5 | GeneProduct | sgd:S000004221 | |
| BNA3 | GeneProduct | sgd:S000003596 | |
| BNA1 | GeneProduct | sgd:S000003786 | |
| BNA4 | GeneProduct | sgd:S000000194 | |
| QNS1 | GeneProduct | sgd:S000001116 | |
| BNA2 | GeneProduct | sgd:S000003839 | |
| NMA1 | GeneProduct | sgd:S000004320 |