JAK-STAT signaling in the regulation of beta cells (WP5358)

Homo sapiens

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JAK-STAT signaling participates in the regulation of key biological processes in Beta-cells, including cell proliferation. Janus kinases (JAKs) serve as a fundamental switch that trigger signal transducer and activator of transcription (STAT) proteins through phosphorylation, which enables downstream target activation and subsequent regulation of target gene transcription. Suppressors of cytokine signaling (SOCS) are negative modulators of JAK-STAT signaling. This pathway is based on a figure by Jiang et al. (2018, doi: 10.3892/etm.2018.6603).

Authors

Isabel Wassink , Egon Willighagen , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Cell Type Ontology

type B pancreatic cell

Pathway Ontology

Jak-Stat signaling pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
FOXM1 GeneProduct ncbigene:2305
IL6 GeneProduct ncbigene:3569
RPTOR GeneProduct ncbigene:57521
KRAS GeneProduct ncbigene:3845
IFNGR2 GeneProduct ncbigene:3460
CCND1 GeneProduct ncbigene:2305
IFNG GeneProduct ncbigene:3458
PRLR GeneProduct ncbigene:5618
EPO GeneProduct ncbigene:2056
NRAS GeneProduct ncbigene:4893
AKT2 GeneProduct ncbigene:208
IFNGR1 GeneProduct ncbigene:3459
CCND3 GeneProduct ncbigene:896
MLST8 GeneProduct ncbigene:64223
STAT1 GeneProduct ncbigene:6772
SOCS2 GeneProduct ncbigene:8835
SOCS1 GeneProduct ncbigene:8651
STAT3 GeneProduct ncbigene:6774
STAT5B GeneProduct ncbigene:6777
AKT3 GeneProduct ncbigene:10000
GHR GeneProduct ncbigene:2690
AKT1S1 GeneProduct ncbigene:84335
JAK2 GeneProduct ncbigene:3717
GH1 GeneProduct ncbigene:2688
EPOR GeneProduct ncbigene:2057
STAT5A GeneProduct ncbigene:6776
CISH GeneProduct ncbigene:1154
MTOR GeneProduct ncbigene:2475
CCND2 GeneProduct ncbigene:894
AKT1 GeneProduct ncbigene:207
IL6R GeneProduct ncbigene:3570
SOCS3 GeneProduct ncbigene:9021
PRL GeneProduct ncbigene:5617
HRAS GeneProduct ncbigene:3265
CDK4 GeneProduct ncbigene:1019

References

  1. Cellular signaling pathways regulating β-cell proliferation as a promising therapeutic target in the treatment of diabetes. Jiang WJ, Peng YC, Yang KM. Exp Ther Med. 2018 Oct;16(4):3275–85. PubMed Europe PMC Scholia