Lysine biosynthesis (WP533)

Saccharomyces cerevisiae

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S. cerevisiae synthesizes the essential amino acid L-lysine via the L-alpha-aminoadipic acid pathway instead of the diaminopmelate pathway (CITS: [10714900]). Originally proposed to be characteristic of fungi, recent studies suggest prokaryotes also synthesize lysine via the alpha-aminoadipic acid pathway (CITS: [11029074]). Intermediates in this pathway are often incorporated into secondary metabolites. For example, it has been well- studied that alpha-aminoadipate is required for penicillin production (CITS: [10714900]). Regulation of the lysine biosynthetic pathway in S. cerevisiae is an interaction between general amino acid control (via Gcn4p) (CITS: [Hinnebusch]), feedback inhibition of homocitrate synthase activity by lysine (CITS: [10103047]), and induction of Lys14p by alpha-aminoadipate semialdehyde (CITS: [10975256]). SOURCE: SGD pathways, http://pathway.yeastgenome.org/server.html

Authors

Meredith Braymer , Daniela Digles , Egon Willighagen , Eric Weitz , and Kristina Hanspers

Activity

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Organisms

Saccharomyces cerevisiae

Communities

Annotations

Pathway Ontology

lysine biosynthetic pathway classic metabolic pathway

Participants

Label Type Compact URI Comment
L-glutamate Metabolite cas:56-86-0
L-Saccharopine Metabolite chebi:16927
2-oxoglutarate Metabolite chebi:16810
L-lysine Metabolite cas:56-87-1
cis-homoaconitate Metabolite hmdb:HMDB60320
NADH Metabolite cas:53-84-9
diphosphate Metabolite hmdb:HMDB00250
Coenzyme A Metabolite cas:64885-97-8
(1R,2S)-homoisocitrate Metabolite chebi:15404
H2O Metabolite hmdb:HMDB02111
Homocitrate Metabolite chebi:36457
CO2 Metabolite chebi:16526
2-oxoadipate Metabolite hmdb:HMDB00225
L-2-aminoadipate Metabolite hmdb:HMDB00510
NADPH Metabolite cas:53-57-6
(S)-2-amino-6-oxohexanoate Metabolite hmdb:HMDB59595
acetyl-CoA Metabolite cas:72-89-9
NADP+ Metabolite hmdb:HMDB00217
H+ Metabolite hmdb:HMDB59597
NAD+ Metabolite hmdb:HMDB00902
ATP Metabolite hmdb:HMDB00538
AMP Metabolite hmdb:HMDB00045
LYS12 GeneProduct sgd:S000001356
LYS2 GeneProduct sgd:S000000319
LYS1 GeneProduct sgd:S000001473
LYS21 GeneProduct sgd:S000002289
LYS4 GeneProduct sgd:S000002642
ARO8 GeneProduct ensembl:YGL202W
LYS20 GeneProduct sgd:S000002341
LYS9 GeneProduct sgd:S000005333

References

  1. In Saccharomyces cerevisae, feedback inhibition of homocitrate synthase isoenzymes by lysine modulates the activation of LYS gene expression by Lys14p. Feller A, Ramos F, Piérard A, Dubois E. Eur J Biochem. 1999 Apr;261(1):163–70. PubMed Europe PMC Scholia
  2. Lysine biosynthesis and metabolism in fungi. Zabriskie TM, Jackson MD. Nat Prod Rep. 2000 Feb;17(1):85–97. PubMed Europe PMC Scholia
  3. Characterisation of a tripartite nuclear localisation sequence in the regulatory protein Lys14 of Saccharomyces cerevisiae. El Alami M, Feller A, Piérard A, Dubois E. Curr Genet. 2000 Aug;38(2):78–86. PubMed Europe PMC Scholia
  4. What is characteristic of fungal lysine synthesis through the alpha-aminoadipate pathway? Nishida H, Nishiyama M. J Mol Evol. 2000 Sep;51(3):299–302. PubMed Europe PMC Scholia
  5. URL: https://biocyc.org/pathway?orgid=META&id=LYSINE-AMINOAD-PWY