Sebaleic acid formation and metabolism (WP5315)
Homo sapiens
Formation of sebaleic acid and its related octadecanoids
Authors
Conroy lipids , Alex Pico , and Eric WeitzActivity
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Organisms
Homo sapiensCommunities
Lipids and LIPID MAPSAnnotations
Pathway Ontology
classic metabolic pathway lipid metabolic pathway fatty acid biosynthetic pathwayLabel | Type | Compact URI | Comment |
---|---|---|---|
Palmitic Acid | Metabolite | lipidmaps:LMFA01010001 | |
Sebaleic acid | Metabolite | lipidmaps:LMFA01030323 | |
5-oxo-18-ODE | Metabolite | lipidmaps:LMFA02000396 | |
Sebaleoyl CoA | Metabolite | lipidmaps:LMFA07050490 | |
Palmitoyl CoA | Metabolite | lipidmaps:LMFA07050360 | |
Sapienic acid | Metabolite | lipidmaps:LMFA01030267 | |
5-KODE | Metabolite | lipidmaps:LMFA02000395 | |
Sapienoyl-CoA | Metabolite | lipidmaps:LMFA07050488 | |
5S-HODE | Metabolite | lipidmaps:LMFA02000394 | |
8Z-octadecenoyl-CoA | Metabolite | lipidmaps:LMFA07050489 | |
5S-18-DiODE | Metabolite | lipidmaps:LMFA02000397 | |
ACSL1et al | GeneProduct | uniprot:P33121 | |
FADS2 | GeneProduct | uniprot:O95864 | EC:1.14.19.3 |
ALOX5 | GeneProduct | uniprot:P09917 | |
FADS1 | GeneProduct | uniprot:O60427 | EC:1.14.19.44 |
CYP4F3 | GeneProduct | uniprot:Q08477 |
References
- Identification of the delta-6 desaturase of human sebaceous glands: expression and enzyme activity. Ge L, Gordon JS, Hsuan C, Stenn K, Prouty SM. J Invest Dermatol. 2003 May;120(5):707–14. PubMed Europe PMC Scholia
- Human neutrophils convert the sebum-derived polyunsaturated fatty acid Sebaleic acid to a potent granulocyte chemoattractant. Cossette C, Patel P, Anumolu JR, Sivendran S, Lee GJ, Gravel S, et al. J Biol Chem. 2008 Apr 25;283(17):11234–43. PubMed Europe PMC Scholia
- Sapienic Acid Metabolism Influences Membrane Plasticity and Protein Signaling in Breast Cancer Cell Lines. Küçüksayan E, Sansone A, Chatgilialoglu C, Ozben T, Tekeli D, Talibova G, et al. Cells. 2022 Jan 11;11(2):225. PubMed Europe PMC Scholia