Sebaleic acid formation and metabolism (WP5315)

Homo sapiens

Formation of sebaleic acid and its related octadecanoids

Authors

Conroy lipids , Alex Pico , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Lipids and LIPID MAPS

Annotations

Pathway Ontology

classic metabolic pathway lipid metabolic pathway fatty acid biosynthetic pathway

Participants

Label Type Compact URI Comment
Palmitic Acid Metabolite lipidmaps:LMFA01010001
Sebaleic acid Metabolite lipidmaps:LMFA01030323
5-oxo-18-ODE Metabolite lipidmaps:LMFA02000396
Sebaleoyl CoA Metabolite lipidmaps:LMFA07050490
Palmitoyl CoA Metabolite lipidmaps:LMFA07050360
Sapienic acid Metabolite lipidmaps:LMFA01030267
5-KODE Metabolite lipidmaps:LMFA02000395
Sapienoyl-CoA Metabolite lipidmaps:LMFA07050488
5S-HODE Metabolite lipidmaps:LMFA02000394
8Z-octadecenoyl-CoA Metabolite lipidmaps:LMFA07050489
5S-18-DiODE Metabolite lipidmaps:LMFA02000397
ACSL1et al GeneProduct uniprot:P33121
FADS2 GeneProduct uniprot:O95864 EC:1.14.19.3
ALOX5 GeneProduct uniprot:P09917
FADS1 GeneProduct uniprot:O60427 EC:1.14.19.44
CYP4F3 GeneProduct uniprot:Q08477

References

  1. Identification of the delta-6 desaturase of human sebaceous glands: expression and enzyme activity. Ge L, Gordon JS, Hsuan C, Stenn K, Prouty SM. J Invest Dermatol. 2003 May;120(5):707–14. PubMed Europe PMC Scholia
  2. Human neutrophils convert the sebum-derived polyunsaturated fatty acid Sebaleic acid to a potent granulocyte chemoattractant. Cossette C, Patel P, Anumolu JR, Sivendran S, Lee GJ, Gravel S, et al. J Biol Chem. 2008 Apr 25;283(17):11234–43. PubMed Europe PMC Scholia
  3. Sapienic Acid Metabolism Influences Membrane Plasticity and Protein Signaling in Breast Cancer Cell Lines. Küçüksayan E, Sansone A, Chatgilialoglu C, Ozben T, Tekeli D, Talibova G, et al. Cells. 2022 Jan 11;11(2):225. PubMed Europe PMC Scholia