Neolacto series sphingolipid metabolism (WP5302)
Homo sapiens
Neolacto series glycosphingolipid bisynthesis.The neolacto series are derived from lactosylceramides (abbreviated as LacCer), which are a class of glycosphingolipids connecting a ceramide lipid to a sugar group. These lipids can have various biological functions that we are not aware of at the moment. Silencing of the B3GNT5 gene was found to lead to various issues in mouse models, including preimplantation lethality, early death, growth inhibition, loss of fur, obesity, reproductive problems, and B-cell functional defects. Source: PMID:24165035.
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Authors
Matthew Conroy , Eric Weitz , and Denise SlenterActivity
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Organisms
Homo sapiensCommunities
Lipids and LIPID MAPSAnnotations
Pathway Ontology
lipid metabolic pathway glycosphingolipid metabolic pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| nLc5Cer | Metabolite | lipidmaps:LMSP0505AK00 | |
| SSEA-1, Lex-5 | Metabolite | lipidmaps:LMSP0505AB00 | |
| Lc3Cer | Metabolite | lipidmaps:LMSP0504AA00 | |
| H1 glycolipid, type II antigen | Metabolite | lipidmaps:LMSP0505AD00 | |
| Type II A antigen | Metabolite | lipidmaps:LMSP0505AF00 | |
| nLc6Ceri antigen | Metabolite | lipidmaps:LMSP0505AL00 | |
| nLc4Cer | Metabolite | lipidmaps:LMSP0505AA00 | ChEBI 17292, Smap 8 |
| NeuAcα2-8NeuAcα2-3Galβ1-4GlcNAcβ1-3Galβ1-4Glcβ-Cer | Metabolite | lipidmaps:LMSP0601EG00 | |
| Sialosylparagloboside | Metabolite | lipidmaps:LMSP0601EF00 | |
| Sialyl LeX | Metabolite | lipidmaps:LMSP0601EE00 | |
| LacCer | Metabolite | lipidmaps:LMSP0501AB00 | |
| B3GNT5 | GeneProduct | uniprot:Q9BYG0 | |
| FUCA1 | GeneProduct | uniprot:P04066 | |
| B4GALT4 | GeneProduct | uniprot:O60513 | |
| B4GALT1 | GeneProduct | uniprot:P15291 | |
| B4GALT3 | GeneProduct | uniprot:O60512 | |
| FUT1 | GeneProduct | uniprot:P19526 | |
| ST3GAL4 | GeneProduct | uniprot:Q11206 | |
| FUT2 | GeneProduct | uniprot:Q10981 | |
| NEU2 | GeneProduct | uniprot:Q9Y3R4 | |
| FUT5 | GeneProduct | uniprot:Q11128 | |
| NAGA | GeneProduct | uniprot:P17050 |
References
- SphinGOMAP--a web-based biosynthetic pathway map of sphingolipids and glycosphingolipids. Merril AH Jr. Glycobiology. 2005 Jun;15(6):15G. PubMed Europe PMC Scholia
- Glycosphingolipids: synthesis and functions. D’Angelo G, Capasso S, Sticco L, Russo D. FEBS J. 2013 Dec;280(24):6338–53. PubMed Europe PMC Scholia