Nephrotoxcicity adverse outcome pathway (WP5229)

Homo sapiens

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Adverse outcome pathway showing the events of nephrotoxicity leading to tubular cell injury and death.

Authors

Julia Johnsson , Marvin Martens , Martina Summer-Kutmon , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

disease pathway

Cell Type Ontology

kidney tubule cell

Disease Ontology

chronic kidney disease acute kidney tubular necrosis

Participants
Query Drugst.One

Label Type Compact URI Comment
SLC22A2 GeneProduct ensembl:ENSG00000112499
SLC31A1 GeneProduct ensembl:ENSG00000136868

References

  1. Cisplatin nephrotoxicity: a review of the literature. Manohar S, Leung N. J Nephrol. 2018 Feb;31(1):15–25. PubMed Europe PMC Scholia
  2. Drug-Induced Acute Kidney Injury. Perazella MA, Rosner MH. Clin J Am Soc Nephrol. 2022 Aug;17(8):1220–33. PubMed Europe PMC Scholia