G13 signaling pathway (WP520)

Rattus norvegicus

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The G13 subunit is an alpha unit of heterotrimeric G proteins that regulates cell processes through the use of guanine nucleotide exchange factors. G13 regulates actin cytoskeletal remodeling in cells and is essential for receptor tyrosine kinase-induced migration of fibroblast and endothelial cells. Source: Wikipedia

Authors

Anita Chow , Manny Ramirez , Thomas Kelder , Christine Chichester , Martina Summer-Kutmon , Eric Weitz , and Kristina Hanspers

Activity

last edited pathway curation

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Cited In

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Organisms

Rattus norvegicus

Communities

Annotations

Pathway Ontology

G protein mediated signaling pathway G protein mediated signaling pathway via Galpha12/Galpha13 family

Participants

Label Type Compact URI Comment
Rtkn GeneProduct ensembl:ENSRNOG00000059679 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6242
Pkn1 GeneProduct ensembl:ENSRNOG00000004131 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5585
Cfl2 GeneProduct ensembl:ENSRNOG00000045892 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1073
Rhpn2 GeneProduct ensembl:ENSRNOG00000011885 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:85415
Rhoa GeneProduct ensembl:ENSRNOG00000050519 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:387
Mk1 GeneProduct ensembl:ENSRNOG00000019657 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5216
Arhgef1 GeneProduct ensembl:ENSRNOG00000020130 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:9138
Cyfip1 GeneProduct ensembl:ENSRNOG00000011945 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:23191
Gna13 GeneProduct ensembl:ENSRNOG00000036745 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10672
Iqgap2 GeneProduct ensembl:ENSRNOG00000025406 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10788
Iqgap1 GeneProduct ensembl:ENSRNOG00000012002 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:8826
Pik3cd GeneProduct ensembl:ENSRNOG00000016846 P42338
Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5293
Arhgdib GeneProduct ensembl:ENSRNOG00000005809 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:397
LOC100910021 GeneProduct ensembl:ENSRNOG00000023622 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5291
Sh3rf1 GeneProduct ensembl:ENSRNOG00000010358 Posh
Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:57630
Limk1 GeneProduct ensembl:ENSRNOG00000001470 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3984
Mybph GeneProduct ensembl:ENSRNOG00000003336 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4608
Rac1 GeneProduct ensembl:ENSRNOG00000001068 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5879
Tnk2 GeneProduct ensembl:ENSRNOG00000001769 S33596
Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10188
Pak3 GeneProduct ensembl:ENSRNOG00000004676 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5063
Pip4k2a GeneProduct ensembl:ENSRNOG00000016670 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5305
Mapk10 GeneProduct ensembl:ENSRNOG00000002079 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5602
AABR07013776.1 GeneProduct ensembl:ENSRNOG00000048082 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:801
Wasl GeneProduct ensembl:ENSRNOG00000006975 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:8976
Pik3r2 GeneProduct ensembl:ENSRNOG00000019228 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5296
Ppp1cb GeneProduct ensembl:ENSRNOG00000004612 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5500
Was GeneProduct ensembl:ENSRNOG00000031058 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7454
Map3k4 GeneProduct ensembl:ENSRNOG00000017419 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4216
Myl1 GeneProduct ensembl:ENSRNOG00000013262 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4632
Cit GeneProduct ensembl:ENSRNOG00000001143 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:11113
Rock1 GeneProduct ensembl:ENSRNOG00000031092 S69211
Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6093
Diaph1 GeneProduct ensembl:ENSRNOG00000019688 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1729
AABR07037536.1 GeneProduct ensembl:ENSRNOG00000056810 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5290
Cdc42 GeneProduct ensembl:ENSRNOG00000013536 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:998
Rps6kb1 GeneProduct ensembl:ENSRNOG00000003919 A41687
Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6198
Rock2 GeneProduct ensembl:ENSRNOG00000004496 BAA31594
Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:9475

References

  1. G protein pathways. Neves SR, Ram PT, Iyengar R. Science. 2002 May 31;296(5573):1636–9. PubMed Europe PMC Scholia