PtdIns(4,5)P2 in cytokinesis pathway (WP5199)

Homo sapiens

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Phosphatidylinositol 4,5-bisphosphate -- also known as PtdIns(4,5)P2 or PIP2 or PI(4,5)P2 -- acts as a central component in the process of bridge stability during the final steps of cytokinesis. Furthermore, PtdIns(4,5)P2 shows bidirectional interactions with many different metabolites such as anillin, ERM-complex. But also Septin2, F-actin and other depicted components visualized in the pathway are required to finalize cytokinesis between two sister cells.

Authors

Soukaina Boudllali , Denise Slenter , Eric Weitz , and Lars Willighagen

Activity

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

signaling pathway phosphatidylinositol metabolic pathway lipid signaling pathway cell cycle pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
PtdIns(4,5)P2 Metabolite chebi:83419
CDP-DAG Metabolite chebi:17962
PtdIns(3,4,5)P3 Metabolite chebi:83416
PCL Metabolite chebi:53200
RhoA GeneProduct ensembl:ENSG00000067560
AFAP1 Protein uniprot:Q8N556
KIF23 Protein uniprot:Q02241
Septin-2 Protein uniprot:Q15019
Ezrin Protein uniprot:P15311
OCLR1 Protein uniprot:Q01968
Anillin Protein uniprot:Q9NQW6
MYL2 Protein uniprot:Q6IB42
Radixin Protein uniprot:P35241
RACGAP1 Protein uniprot:Q9H0H5
Moesin Protein uniprot:P26038
RAB35 Protein uniprot:Q15286

References

  1. Anillin. Zhang L, Maddox AS. Curr Biol. 2010 Feb 23;20(4):R135-6. PubMed Europe PMC Scholia
  2. Organizing the cell cortex: the role of ERM proteins. Fehon RG, McClatchey AI, Bretscher A. Nat Rev Mol Cell Biol. 2010 Apr;11(4):276–87. PubMed Europe PMC Scholia
  3. Rab35 GTPase and OCRL phosphatase remodel lipids and F-actin for successful cytokinesis. Dambournet D, Machicoane M, Chesneau L, Sachse M, Rocancourt M, El Marjou A, et al. Nat Cell Biol. 2011 Jun 26;13(8):981–8. PubMed Europe PMC Scholia
  4. OCRL controls trafficking through early endosomes via PtdIns4,5P₂-dependent regulation of endosomal actin. Vicinanza M, Di Campli A, Polishchuk E, Santoro M, Di Tullio G, Godi A, et al. EMBO J. 2011 Oct 4;30(24):4970–85. PubMed Europe PMC Scholia
  5. Cleavage furrow organization requires PIP(2)-mediated recruitment of anillin. Liu J, Fairn GD, Ceccarelli DF, Sicheri F, Wilde A. Curr Biol. 2012 Jan 10;22(1):64–9. PubMed Europe PMC Scholia
  6. Phosphoinositides and cytokinesis: the “PIP” of the iceberg. Echard A. Cytoskeleton (Hoboken). 2012 Nov;69(11):893–912. PubMed Europe PMC Scholia
  7. Rho GTPases, phosphoinositides, and actin: a tripartite framework for efficient vesicular trafficking. Croisé P, Estay-Ahumada C, Gasman S, Ory S. Small GTPases. 2014;5:e29469. PubMed Europe PMC Scholia
  8. Phospholipase C and D regulation of Src, calcium release and membrane fusion during Xenopus laevis development. Stith BJ. Dev Biol. 2015 May 15;401(2):188–205. PubMed Europe PMC Scholia