Inflammatory bowel disease signaling (WP5198)

Homo sapiens

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Pathway representing the inflammatory bowel disease showing steps leading to Crohn's disease and ulcerative colitis.

Authors

Zuzanna Lech , Josephine-Elisabeth Pippi , Andra Waagmeester , Susan Coort , Imke Grutters , Egon Willighagen , Eric Weitz , and Martina Summer-Kutmon

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

disease pathway altered cytokine mediated signaling pathway interleukin-2 signaling pathway signaling pathway involving second messengers Toll-like receptor signaling pathway interleukin-12 family mediated signaling pathway

Cell Type Ontology

T-helper 2 cell T-helper 1 cell naive thymus-derived CD4-positive, alpha-beta T cell colon macrophage macrophage lymphocyte T-helper 17 cell professional antigen presenting cell

Disease Ontology

Crohn's disease inflammatory bowel disease inflammatory bowel disease ulcerative colitis colonic disease immune system disease colitis

Participants
Query Drugst.One

Label Type Compact URI Comment
Peptidoglycan Metabolite chebi:8005
MDP Metabolite chebi:183049
NF-kB GeneProduct ensembl:ENSG00000109320
IL18RAP GeneProduct ensembl:ENSG00000115607
STAT1 GeneProduct ensembl:ENSG00000115415
IL5 GeneProduct ensembl:ENSG00000113525
IFNG GeneProduct ensembl:ENSG00000111537
TNFA GeneProduct ensembl:ENSG00000232810
T-bet GeneProduct ensembl:ENSG00000073861
STAT6 GeneProduct ensembl:ENSG00000166888
IL17 GeneProduct ensembl:ENSG00000112116
IL23A GeneProduct ensembl:ENSG00000110944
STAT3 GeneProduct ensembl:ENSG00000168610
IL2RG GeneProduct ensembl:ENSG00000147168
IL12 GeneProduct ensembl:ENSG00000168811
IL4 GeneProduct ensembl:ENSG00000113520
IL10 GeneProduct ensembl:ENSG00000136634
GATA3 GeneProduct ensembl:ENSG00000107485
TGFB1 GeneProduct ensembl:ENSG00000105329
FOXP3 GeneProduct ensembl:ENSG00000049768
IFNGR1 GeneProduct ensembl:ENSG00000027697
NOD2 GeneProduct ensembl:ENSG00000167207
IL6 GeneProduct ensembl:ENSG00000136244
RORA GeneProduct ensembl:ENSG00000069667
TLR2 GeneProduct ensembl:ENSG00000137462
IL12RB2 GeneProduct ensembl:ENSG00000081985
TLR5 GeneProduct ensembl:ENSG00000187554
NFKB1 GeneProduct ensembl:ENSG00000109320
IL13 GeneProduct ensembl:ENSG00000169194
IL23R GeneProduct ensembl:ENSG00000162594
STAT4 GeneProduct ensembl:ENSG00000138378
IL18 GeneProduct ensembl:ENSG00000150782
NFATC1 GeneProduct ensembl:ENSG00000131196
IL12RB1 GeneProduct ensembl:ENSG00000096996
TNF GeneProduct ensembl:ENSG00000232810
TLR4 GeneProduct ensembl:ENSG00000136869
AP1 GeneProduct ensembl:ENSG00000177606
IL2 GeneProduct ensembl:ENSG00000109471
IL21 GeneProduct ensembl:ENSG00000138684
IL21R GeneProduct ensembl:ENSG00000103522
TGFB GeneProduct ensembl:ENSG00000105329
IL1 GeneProduct ensembl:ENSG00000115008
SMAD2 GeneProduct ensembl:ENSG00000175387
IL-4RA GeneProduct ensembl:ENSG00000077238
c-MAF GeneProduct ensembl:ENSG00000178573
RORC GeneProduct ensembl:ENSG00000143365
IL22 GeneProduct ensembl:ENSG00000127318
MHC class 2 Protein ensembl:ENSG00000204257

References

  1. The fundamental basis of inflammatory bowel disease. Strober W, Fuss I, Mannon P. J Clin Invest. 2007 Mar;117(3):514–21. PubMed Europe PMC Scholia
  2. IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn’s disease. Kobayashi T, Okamoto S, Hisamatsu T, Kamada N, Chinen H, Saito R, et al. Gut. 2008 Dec;57(12):1682–9. PubMed Europe PMC Scholia
  3. A Comprehensive Review and Update on the Pathogenesis of Inflammatory Bowel Disease. Guan Q. J Immunol Res. 2019 Dec 1;2019:7247238. PubMed Europe PMC Scholia
  4. Role of the IL23/IL17 Pathway in Crohn’s Disease. Schmitt H, Neurath MF, Atreya R. Front Immunol. 2021 Mar 30;12:622934. PubMed Europe PMC Scholia