SARS-CoV-2 replication organelle formation (WP5156)

Homo sapiens

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Components of the class III PI3K complex is speculated to promote SARS-CoV-2 replication. PI3P and DFCP1 contribute to the formation of double membrane vesicles needed for viral replication. Nsp3 protein from SARS-CoV 2 stimulates the accumulation of PI3P.

Authors

Nhung Pham , Eric Weitz , Egon Willighagen , and Martina Summer-Kutmon

Activity

last edited

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Organisms

Homo sapiens

Communities

COVID-19

Annotations

Disease Ontology

COVID-19

Pathway Ontology

infectious disease pathway disease pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
PI3P Metabolite chebi:26034
Beclin-1 Protein uniprot:Q14457
VPS15 Protein uniprot:Q99570
VPS34 Protein uniprot:Q8NEB9
AMBRA Protein uniprot:Q9C0C7
ATG14 Protein uniprot:Q6ZNE5
DFCP1 Protein uniprot:Q9HBF4
nsp3 Protein ncbiprotein:YP_009725299
rep 1ab Protein uniprot:P0DTD1

References

  1. Contribution of autophagy machinery factors to HCV and SARS-CoV-2 replication organelle formation. Twu WI, Lee JY, Kim H, Prasad V, Cerikan B, Haselmann U, et al. Cell Rep. 2021 Nov 23;37(8):110049. PubMed Europe PMC Scholia