NIPBL role in DNA damage - Cornelia de Lange syndrome (WP5119)

Homo sapiens

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Recruitment of cohesin subunit NIPBL after DNA damage.

Authors

Alp Irkilmez , Eric Weitz , Lars Willighagen , and Martina Summer-Kutmon

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Disease Ontology

Cornelia de Lange syndrome

Pathway Ontology

disease pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
CBX3 GeneProduct ensembl:ENSG00000122565
NIPBL GeneProduct ensembl:ENSG00000164190
ATM GeneProduct ensembl:ENSG00000149311
ATR GeneProduct ensembl:ENSG00000175054
RNF8 GeneProduct ensembl:ENSG00000112130
RNF168 GeneProduct ensembl:ENSG00000163961
MDC1 GeneProduct ensembl:ENSG00000137337
Histone H2AX Protein uniprot:P16104

References

  1. Recruitment of the cohesin loading factor NIPBL to DNA double-strand breaks depends on MDC1, RNF168 and HP1γ in human cells. Oka Y, Suzuki K, Yamauchi M, Mitsutake N, Yamashita S. Biochem Biophys Res Commun. 2011 Aug 12;411(4):762–7. PubMed Europe PMC Scholia
  2. Independent mechanisms recruit the cohesin loader protein NIPBL to sites of DNA damage. Bot C, Pfeiffer A, Giordano F, Manjeera DE, Dantuma NP, Ström L. J Cell Sci. 2017 Mar 15;130(6):1134–46. PubMed Europe PMC Scholia