Cohesin complex - Cornelia de Lange syndrome (WP5117)
Homo sapiens
Cohesin complex workings during mitotic and meiotic cell cycles.
Authors
Alp Irkilmez , Eric Weitz , and Martina Summer-KutmonActivity
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Organisms
Homo sapiensCommunities
Annotations
Disease Ontology
Cornelia de Lange syndromePathway Ontology
disease pathwayReferences
- Dissociation of cohesin from chromosome arms and loss of arm cohesion during early mitosis depends on phosphorylation of SA2. Hauf S, Roitinger E, Koch B, Dittrich CM, Mechtler K, Peters JM. PLoS Biol. 2005 Mar;3(3):e69. PubMed Europe PMC Scholia
- Cornelia de Lange syndrome, cohesin, and beyond. Liu J, Krantz ID. Clin Genet. 2009 Oct;76(4):303–14. PubMed Europe PMC Scholia
- Cohesin acetyltransferase Esco2 is a cell viability factor and is required for cohesion in pericentric heterochromatin. Whelan G, Kreidl E, Wutz G, Egner A, Peters JM, Eichele G. EMBO J. 2012 Jan 4;31(1):71–82. PubMed Europe PMC Scholia
- HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle. Deardorff MA, Bando M, Nakato R, Watrin E, Itoh T, Minamino M, et al. Nature. 2012 Sep 13;489(7415):313–7. PubMed Europe PMC Scholia
- Aurora B and Cdk1 mediate Wapl activation and release of acetylated cohesin from chromosomes by phosphorylating Sororin. Nishiyama T, Sykora MM, Huis in ’t Veld PJ, Mechtler K, Peters JM. Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13404–9. PubMed Europe PMC Scholia
- Structure of the Pds5-Scc1 Complex and Implications for Cohesin Function. Muir KW, Kschonsak M, Li Y, Metz J, Haering CH, Panne D. Cell Rep. 2016 Mar 8;14(9):2116–26. PubMed Europe PMC Scholia
- The cohesin complex in mammalian meiosis. Ishiguro KI. Genes Cells. 2019 Jan;24(1):6–30. PubMed Europe PMC Scholia
- Functioning mechanisms of Shugoshin-1 in centromeric cohesion during mitosis. Zhang Q, Liu H. Essays Biochem. 2020 Sep 4;64(2):289–97. PubMed Europe PMC Scholia
- Pds5A and Pds5B Display Non-redundant Functions in Mitosis and Their Loss Triggers Chk1 Activation. Al-Jomah N, Mukololo L, Anjum A, Al Madadha M, Patel R. Front Cell Dev Biol. 2020 Jul 14;8:531. PubMed Europe PMC Scholia