Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway (WP5113)
Homo sapiens
Antiviral and antihypertensive effects of Nrf2 and its link to SARS-CoV-2 infection.
Authors
Rocheliene , Eric Weitz , Martina Summer-Kutmon , and Nhung PhamActivity
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Organisms
Homo sapiensCommunities
COVID-19Annotations
Pathway Ontology
nuclear factor, erythroid 2 like 2 signaling pathwayDisease Ontology
COVID-19| Label | Type | Compact URI | Comment |
|---|---|---|---|
| GTP | Metabolite | chebi:37565 | |
| CO | Metabolite | chebi:17245 | |
| Heme | Metabolite | hmdb:HMDB03178 | |
| cGMP | Metabolite | chebi:16356 | |
| iron | Metabolite | chebi:29033 | |
| ROS | Metabolite | chebi:26523 | |
| biliverdin | Metabolite | chebi:17033 | |
| HMOX1 | GeneProduct | ncbigene:3162 | |
| TMPRSS2 | GeneProduct | ensembl:ENSG00000184012 | |
| ACE2 | GeneProduct | ncbigene:59272 | |
| orf1 | GeneProduct | ncbigene:43740578 | |
| NFE2L2 | GeneProduct | ensembl:ENSG00000116044 | |
| KEAP1 | GeneProduct | ensembl:ENSG00000079999 | |
| MAF | GeneProduct | ensembl:ENSG00000186350 | |
| GCLC | GeneProduct | ncbigene:2729 | |
| SLC7A11 | GeneProduct | ensembl:ENSG00000151012 | |
| NQO1 | GeneProduct | ncbigene:1728 | |
| GSTA2 | GeneProduct | ncbigene:2939 | |
| GCLM | GeneProduct | ncbigene:2730 | |
| IRF3 | GeneProduct | ensembl:ENSG00000126456 | |
| CXCL8 | GeneProduct | ensembl:ENSG00000169429 | |
| MMP3 | GeneProduct | ensembl:ENSG00000149968 | |
| TNF | GeneProduct | ensembl:ENSG00000232810 | |
| CCL2 | GeneProduct | ncbigene:6347 | |
| IL12A | GeneProduct | ensembl:ENSG00000168811 | |
| IL1B | GeneProduct | ensembl:ENSG00000125538 | |
| MMP1 | GeneProduct | ensembl:ENSG00000196611 | |
| IL6 | GeneProduct | ensembl:ENSG00000136244 | |
| GUCY1B2 | GeneProduct | ensembl:ENSG00000123201 | |
| GUCY1A2 | GeneProduct | ensembl:ENSG00000152402 | |
| GUCY1A3 | GeneProduct | ensembl:ENSG00000164116 | |
| GUCY1B3 | GeneProduct | ensembl:ENSG00000061918 | |
| PKG2 | GeneProduct | ensembl:ENSG00000138669 | |
| NOX1 | GeneProduct | ensembl:ENSG00000007952 | |
| NFKBIA | GeneProduct | ensembl:ENSG00000100906 | |
| p65 | GeneProduct | ensembl:ENSG00000173039 | |
| NFKB1 | GeneProduct | ensembl:ENSG00000109320 | |
| IKKB | GeneProduct | ensembl:ENSG00000104365 | |
| CHUK | GeneProduct | ensembl:ENSG00000213341 | |
| IKKG | GeneProduct | ensembl:ENSG00000269335 | |
| RELA | GeneProduct | ensembl:ENSG00000173039 | |
| orf1ab | Protein | uniprot:P0DTD1 | |
| nsp8 | Protein | wikidata:Q88659350 | |
| nsp7 | Protein | wikidata:Q90038963 | |
| nsp12 | Protein | wikidata:Q94647436 | RdRp |
| nsp3 | Protein | wikidata:Q87917581 | nsp3 |
| nsp5 | Protein | wikidata:Q87917582 | |
| INF-I alpha/ beta | Protein | wikidata:Q6046488 |
References
- Structure of the RNA-dependent RNA polymerase from COVID-19 virus. Gao Y, Yan L, Huang Y, Liu F, Zhao Y, Cao L, et al. Science. 2020 May 15;368(6492):779–82. PubMed Europe PMC Scholia
- Remdesivir and SARS-CoV-2: Structural requirements at both nsp12 RdRp and nsp14 Exonuclease active-sites. Shannon A, Le NTT, Selisko B, Eydoux C, Alvarez K, Guillemot JC, et al. Antiviral Res. 2020 Jun;178:104793. PubMed Europe PMC Scholia
- Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant. Pachetti M, Marini B, Benedetti F, Giudici F, Mauro E, Storici P, et al. J Transl Med. 2020 Apr 22;18(1):179. PubMed Europe PMC Scholia
- Structure of replicating SARS-CoV-2 polymerase. Hillen HS, Kokic G, Farnung L, Dienemann C, Tegunov D, Cramer P. Nature. 2020 Aug;584(7819):154–6. PubMed Europe PMC Scholia
- Chemistry and Biology of SARS-CoV-2. Dömling A, Gao L. Chem. 2020 Jun 11;6(6):1283–95. PubMed Europe PMC Scholia