Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway (WP5113)

Homo sapiens

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Antiviral and antihypertensive effects of Nrf2 and its link to SARS-CoV-2 infection.

For a description of pathway objects, see the WikiPathways Legend.

Authors

Rocheliene , Eric Weitz , Martina Summer-Kutmon , and Nhung Pham

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

COVID-19 ONTOX

Annotations

Pathway Ontology

nuclear factor, erythroid 2 like 2 signaling pathway

Disease Ontology

COVID-19

Participants
Query Drugst.One

Label Type Compact URI Comment
GTP Metabolite chebi:37565
CO Metabolite chebi:17245
Heme Metabolite hmdb:HMDB03178
cGMP Metabolite chebi:16356
iron Metabolite chebi:29033
ROS Metabolite chebi:26523
biliverdin Metabolite chebi:17033
HMOX1 GeneProduct ncbigene:3162
TMPRSS2 GeneProduct ensembl:ENSG00000184012
ACE2 GeneProduct ncbigene:59272
orf1 GeneProduct ncbigene:43740578
NFE2L2 GeneProduct ensembl:ENSG00000116044
KEAP1 GeneProduct ensembl:ENSG00000079999
MAF GeneProduct ensembl:ENSG00000186350
GCLC GeneProduct ncbigene:2729
SLC7A11 GeneProduct ensembl:ENSG00000151012
NQO1 GeneProduct ncbigene:1728
GSTA2 GeneProduct ncbigene:2939
GCLM GeneProduct ncbigene:2730
IRF3 GeneProduct ensembl:ENSG00000126456
CXCL8 GeneProduct ensembl:ENSG00000169429
MMP3 GeneProduct ensembl:ENSG00000149968
TNF GeneProduct ensembl:ENSG00000232810
CCL2 GeneProduct ncbigene:6347
IL12A GeneProduct ensembl:ENSG00000168811
IL1B GeneProduct ensembl:ENSG00000125538
MMP1 GeneProduct ensembl:ENSG00000196611
IL6 GeneProduct ensembl:ENSG00000136244
GUCY1B2 GeneProduct ensembl:ENSG00000123201
GUCY1A2 GeneProduct ensembl:ENSG00000152402
GUCY1A3 GeneProduct ensembl:ENSG00000164116
GUCY1B3 GeneProduct ensembl:ENSG00000061918
PKG2 GeneProduct ensembl:ENSG00000138669
NOX1 GeneProduct ensembl:ENSG00000007952
NFKBIA GeneProduct ensembl:ENSG00000100906
p65 GeneProduct ensembl:ENSG00000173039
NFKB1 GeneProduct ensembl:ENSG00000109320
IKKB GeneProduct ensembl:ENSG00000104365
CHUK GeneProduct ensembl:ENSG00000213341
IKKG GeneProduct ensembl:ENSG00000269335
RELA GeneProduct ensembl:ENSG00000173039
orf1ab Protein uniprot:P0DTD1
nsp8 Protein wikidata:Q88659350
nsp7 Protein wikidata:Q90038963
nsp12 Protein wikidata:Q94647436 RdRp
nsp3 Protein wikidata:Q87917581 nsp3
nsp5 Protein wikidata:Q87917582
INF-I alpha/ beta Protein wikidata:Q6046488

References

  1. Structure of the RNA-dependent RNA polymerase from COVID-19 virus. Gao Y, Yan L, Huang Y, Liu F, Zhao Y, Cao L, et al. Science. 2020 May 15;368(6492):779–82. PubMed Europe PMC Scholia
  2. Remdesivir and SARS-CoV-2: Structural requirements at both nsp12 RdRp and nsp14 Exonuclease active-sites. Shannon A, Le NTT, Selisko B, Eydoux C, Alvarez K, Guillemot JC, et al. Antiviral Res. 2020 Jun;178:104793. PubMed Europe PMC Scholia
  3. Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant. Pachetti M, Marini B, Benedetti F, Giudici F, Mauro E, Storici P, et al. J Transl Med. 2020 Apr 22;18(1):179. PubMed Europe PMC Scholia
  4. Structure of replicating SARS-CoV-2 polymerase. Hillen HS, Kokic G, Farnung L, Dienemann C, Tegunov D, Cramer P. Nature. 2020 Aug;584(7819):154–6. PubMed Europe PMC Scholia
  5. Chemistry and Biology of SARS-CoV-2. Dömling A, Gao L. Chem. 2020 Jun 11;6(6):1283–95. PubMed Europe PMC Scholia