SARS-CoV-2 altering angiogenesis via NRP1 (WP5065)
Homo sapiens
Mechanism of how the SARS-cov-2 virus is involved in altering angiogenesis and how NRP1 might play a role as an entry factor for the virus.
Authors
Simon Vossen , Friederike Ehrhart , Lena Szabo , Eric Weitz , and Nhung PhamActivity
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Organisms
Homo sapiensCommunities
COVID-19Annotations
Disease Ontology
COVID-19 severe acute respiratory syndromePathway Ontology
disease pathwayLabel | Type | Compact URI | Comment |
---|---|---|---|
FURIN | GeneProduct | ensembl:ENSG00000140564 | |
NRP1 | GeneProduct | ensembl:ENSG00000099250 | |
KDR | GeneProduct | ensembl:ENSG00000128052 | |
ACE2 | GeneProduct | ensembl:ENSG00000130234 | |
VEGFA | GeneProduct | ensembl:ENSG00000112715 | |
S2 | Protein | wikidata:Q106020384 | |
Surface glycoprotein S | Protein | uniprot:P0DTC2 | |
S1 | Protein | wikidata:Q106020256 |
References
- Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Soker S, Takashima S, Miao HQ, Neufeld G, Klagsbrun M. Cell. 1998 Mar 20;92(6):735–45. PubMed Europe PMC Scholia
- SARS-CoV-2 Spike protein co-opts VEGF-A/Neuropilin-1 receptor signaling to induce analgesia. Moutal A, Martin LF, Boinon L, Gomez K, Ran D, Zhou Y, et al. bioRxiv. 2020 Sep 14;2020.07.17.209288. PubMed Europe PMC Scholia
- Neuropilin-1 is a host factor for SARS-CoV-2 infection. Daly JL, Simonetti B, Klein K, Chen KE, Williamson MK, Antón-Plágaro C, et al. Science. 2020 Nov 13;370(6518):861–5. PubMed Europe PMC Scholia
- The role of Neuropilin-1 in COVID-19. Mayi BS, Leibowitz JA, Woods AT, Ammon KA, Liu AE, Raja A. PLoS Pathog. 2021 Jan 4;17(1):e1009153. PubMed Europe PMC Scholia
- Neuropilin-1 Assists SARS-CoV-2 Infection by Stimulating the Separation of Spike Protein Domains S1 and S2. Li ZL, Buck M. bioRxiv. 2021 Jan 19;2021.01.06.425627. PubMed Europe PMC Scholia
- Neurobiology of SARS-CoV-2 interactions with the peripheral nervous system: implications for COVID-19 and pain. McFarland AJ, Yousuf MS, Shiers S, Price TJ. Pain Rep. 2021 Jan 7;6(1):e885. PubMed Europe PMC Scholia