Acetogenesis (WP5019)
Acetobacterium woodii
Acetogenesis from H2 and CO2 in Acetobacterium woodii, based on Figure 3 from Diender et al (2015) [PMID:26635746]. This pathway model shows both proposed theoretical pathways of CO conversion to acetate, as well as the acetogenic metabolism driven by CO co-fermented with formate. Two large complexes are involved in this process (top right corner): 1. the RnF complex (sodium ion transport outside of the cell membrane) 2. the ATPase complex (sodium ion translocation to inner cell membrane).
Authors
Lars Willighagen , Kristina Hanspers , and Denise SlenterActivity
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Organisms
Communities
Annotations
Pathway Ontology
classic metabolic pathway carbon fixation pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| formate | Metabolite | chebi:15740 | |
| ATP | Metabolite | chebi:30616 | |
| hydron | Metabolite | chebi:15378 | |
| 5-Methyltetrahydrofolate | Metabolite | chebi:15641 | |
| HSCoA | Metabolite | chebi:15346 | |
| ADP | Metabolite | chebi:456216 | |
| 5,10-Methylenetetrahydrofolate | Metabolite | chebi:1989 | |
| dihydrogen | Metabolite | chebi:18276 | |
| acetate | Metabolite | chebi:30089 | |
| carbon dioxide | Metabolite | chebi:16526 | |
| carbon monooxide | Metabolite | chebi:17245 | |
| methyl | Metabolite | chebi:32875 | |
| 5,10-Methenyltetrahydrofolate | Metabolite | chebi:15638 | |
| 10-Formyltetrahydrofolate | Metabolite | chebi:15637 | |
| Tetrahydrofolate | Metabolite | chebi:20506 | |
| hydrogenphosphate | Metabolite | chebi:43474 | |
| acetyl-CoA | Metabolite | chebi:15351 | |
| NADH | Metabolite | chebi:16908 | |
| NAD(1-) | Metabolite | chebi:57540 | |
| Oxidised ferredoxin | Metabolite | chebi:17908 | |
| Reduced ferredoxin | Metabolite | chebi:17513 | |
| acetyl-phosphate | Metabolite | chebi:15350 | |
| MetV | Protein | uniprot:H6LBX8 | |
| RnfG | Protein | uniprot:H6LC30 | |
| FdhF1 | Protein | uniprot:H6LB59 | |
| RnfC | Protein | uniprot:H6LC32 | |
| Fhs1 | Protein | uniprot:H6LBX4 | Formate--tetrahydrofolate ligase |
| RnfC2 | Protein | uniprot:H6LBX7 | |
| RnfD | Protein | uniprot:H6LC31 | |
| MetF | Protein | uniprot:H6LBX9 | |
| HycB2 | Protein | uniprot:H6LB62 | |
| RnfA | Protein | uniprot:H6LC28 | |
| RnfB | Protein | uniprot:H6LC27 | |
| HycB1 | Protein | uniprot:H6LB60 | |
| RnfE | Protein | uniprot:H6LC29 | |
| HydD | Protein | uniprot:H6LFG5 | |
| AcsA | Protein | uniprot:H6LD21 | CO dehydrogenase |
| HydA1 | Protein | uniprot:H6LFG3 | |
| HycB3 | Protein | uniprot:H6LB64 | |
| AtpE | Protein | uniprot:Q9RMB5 | Subunit c |
| HydA2 | Protein | uniprot:H6LB65 | |
| HydB | Protein | uniprot:H6LFG4 | |
| HydC | Protein | uniprot:H6LFG7 | |
| FdhF2 | Protein | uniprot:H6LB61 | |
| AtpB | Protein | uniprot:Q9RMB6 | Subunit a |
| AtpH | Protein | uniprot:Q9RMB3 | Subunit delta |
| AtpF | Protein | uniprot:Q9RMB4 | Subunit b |
| AtpD | Protein | uniprot:P50002 | Subunit beta |
| AtpC | Protein | uniprot:P50009 | Subunit epsilon |
| AtpG | Protein | uniprot:P50005 | Subunit gamma |
| AtpA | Protein | uniprot:P50000 | Subunit alpha |
| FolD | Protein | uniprot:H6LBX6 | |
| FchA | Protein | uniprot:H6LBX5 | Methenyl-THF cyclohydrolase |
| AcsE | Protein | uniprot:H6LD20 | Methyl-transferase |
| AcsD | Protein | uniprot:H6LD18 | Small subunit |
| AcsC | Protein | uniprot:H6LD19 | Large subunit |
| AcsB1 | Protein | uniprot:H6LD23 | Acetyl-CoA synthase |
| Pta | Protein | uniprot:H6LJY6 | |
| AckA | Protein | uniprot:H6LBE7 | acetate kinase |
References
- Pathways and Bioenergetics of Anaerobic Carbon Monoxide Fermentation. Diender M, Stams AJM, Sousa DZ. Front Microbiol. 2015 Nov 19;6:1275. PubMed Europe PMC Scholia