Deregulation of renin-angiotensin system by SARS-CoV infection (WP4965)
Mus musculus
The spike protein of SARS-CoV down regulates ACE2, leading to deregulation of the renin-angiotensin system. This deregulation can be the cause of lung injury that is linked to SARS-CoV infection. This work was done in a mouse model.
Authors
Jordi Doijen , Egon Willighagen , Denise Slenter , Eric Weitz , and Martina Summer-KutmonActivity
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Cited In
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Organisms
Mus musculusCommunities
COVID-19Annotations
Cell Type Ontology
native cellDisease Ontology
viral infectious diseasePathway Ontology
G protein mediated signaling pathwayLabel | Type | Compact URI | Comment |
---|---|---|---|
Angiotensin II | Metabolite | hmdb:HMDB0001035 | |
Angiotensin I | Metabolite | hmdb:HMDB0061196 | |
Angiotensin-(1-7) | Metabolite | chebi:55438 | |
Angiotensinogen | Metabolite | chebi:2720 | |
Angiotensin-(1-9) | Metabolite | chebi:80128 | |
Agtr1a | GeneProduct | ensembl:ENSMUSG00000049115 | |
Ace2 | GeneProduct | ensembl:ENSMUSG00000015405 | |
Ace | GeneProduct | ensembl:ENSMUSG00000020681 | |
Agtr2 | GeneProduct | ensembl:ENSMUSG00000068122 |
References
- A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury. Kuba K, Imai Y, Rao S, Gao H, Guo F, Guan B, et al. Nat Med. 2005 Aug;11(8):875–9. PubMed Europe PMC Scholia