Autophagy (WP4923)

Homo sapiens

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Autophagy is a type of process that cell allows itself to degrade intracellular components, including organelles, proteins and foreign bodies. Autophagy is inhibited by mTORC1 and activated by AMPK. The process requires four steps: initiation, formation, membrane expansion and maturation, which are characterised by the structures that are roughly represented by the structures that are present: the omegasome, phagophore, atophagosome and finally autolysosme. It requires formation of the autophagosome, a double-membrane structure filled with the isolated cytoplasmic material that the cell wants to remove. The autophagosome eventually fuses with the lysosome to form the autolysosome.

Authors

Anna Baya Meuleman

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

autophagy pathway cell death pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
PE Metabolite chebi:16038
PtdIns3P Metabolite chebi:17283
ATG14 GeneProduct ensembl:ENSG00000126775
PIK3R4 GeneProduct ensembl:ENSG00000196455
PRKAG1 GeneProduct ensembl:ENSG00000181929
ATG5 GeneProduct ensembl:ENSG00000057663
PRKAA2 GeneProduct ensembl:ENSG00000162409
AKT1S1 GeneProduct ensembl:ENSG00000204673
PIK3C3 GeneProduct ensembl:ENSG00000078142
BECN1 GeneProduct ensembl:ENSG00000126581
MAP1LC3B GeneProduct ensembl:ENSG00000140941
AMBRA1 GeneProduct ensembl:ENSG00000110497
ATG3 GeneProduct ensembl:ENSG00000144848
WIPI2 GeneProduct ensembl:ENSG00000157954
PRKAA1 GeneProduct ensembl:ENSG00000132356
ULK1 GeneProduct ensembl:ENSG00000177169
PRKAG2 GeneProduct ensembl:ENSG00000106617
ATG16L1 GeneProduct ensembl:ENSG00000085978
MLST8 GeneProduct ensembl:ENSG00000167965
UVRAG GeneProduct ensembl:ENSG00000198382
PRKAB2 GeneProduct ensembl:ENSG00000131791
MTOR GeneProduct ensembl:ENSG00000198793
ATG101 GeneProduct ensembl:ENSG00000123395
PRKAG3 GeneProduct ensembl:ENSG00000115592
ATG9A GeneProduct ensembl:ENSG00000198925
RPTOR GeneProduct ensembl:ENSG00000141564
ATG12 GeneProduct ensembl:ENSG00000145782
RB1CC1 GeneProduct ensembl:ENSG00000023287
DEPTOR GeneProduct ensembl:ENSG00000155792
PRKAB1 GeneProduct ensembl:ENSG00000111725
ATG7 GeneProduct ensembl:ENSG00000197548
ATG13 GeneProduct ensembl:ENSG00000175224

References

  1. Autophagy pathway: Cellular and molecular mechanisms. Yu L, Chen Y, Tooze SA. Autophagy. 2018;14(2):207–15. PubMed Europe PMC Scholia
  2. The C-terminal region of ATG101 bridges ULK1 and PtdIns3K complex in autophagy initiation. Kim BW, Jin Y, Kim J, Kim JH, Jung J, Kang S, et al. Autophagy. 2018;14(12):2104–16. PubMed Europe PMC Scholia
  3. AMPK contributes to autophagosome maturation and lysosomal fusion. Jang M, Park R, Kim H, Namkoong S, Jo D, Huh YH, et al. Sci Rep. 2018 Aug 23;8(1):12637. PubMed Europe PMC Scholia
  4. AMPK: Regulation of Metabolic Dynamics in the Context of Autophagy. Tamargo-Gómez I, Mariño G. Int J Mol Sci. 2018 Nov 29;19(12):3812. PubMed Europe PMC Scholia