Hepatocyte growth factor receptor signaling (WP444)

Danio rerio

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Signaling pathway of the Hepatocyte Growth Factor Receptor (Homo sapiens) also know as C-Met. The C-Met activation results in the stimulation of a variety of intracellular signalling pathways, which regulate several processes such as: motility, migration, proliferation and invasion.

For a description of pathway objects, see the WikiPathways Legend.

Authors

Daniela Digles , Lauren J. Dupuis , Eric Weitz , Denise Slenter , and Egon Willighagen

Activity

last edited

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Cited In

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Organisms

Danio rerio

Communities

Annotations

Cell Type Ontology

hepatocyte

Pathway Ontology

Rho/Rac/Cdc42 mediated signaling pathway scatter factor/hepatocyte growth factor signaling pathway

Participants

Label Type Compact URI Comment
CH211-127H20.2 GeneProduct ncbigene:558635
raf1 GeneProduct ncbigene:30716
rap1b GeneProduct ncbigene:321107
src GeneProduct ncbigene:325084
ptk2.1 GeneProduct ncbigene:142986
crk GeneProduct ncbigene:445234
ptk2bb GeneProduct ncbigene:245950
pxn GeneProduct ncbigene:399546
gab1 GeneProduct ncbigene:406666
ptenb GeneProduct ncbigene:368415
hgfa GeneProduct ncbigene:493781
zgc:172250 GeneProduct ncbigene:100002225
rasa1 GeneProduct ncbigene:100002155
map2k1 GeneProduct ncbigene:406728
LOC570868 GeneProduct ncbigene:570868
LOC567895 GeneProduct ncbigene:567895
rap1a GeneProduct ncbigene:415242
mapk1 GeneProduct ncbigene:360144
pak1 GeneProduct ncbigene:373103
zgc:172209 GeneProduct ncbigene:562720
LOC561737 GeneProduct ncbigene:561737
crkl GeneProduct ncbigene:556443
stat3 GeneProduct ncbigene:30767
HRAS GeneProduct ncbigene:550286
jun GeneProduct ncbigene:335916
grb2 GeneProduct ncbigene:406308
dock1 GeneProduct ncbigene:572187 Interim Symbol: Dock1 predicted and Name: dedicator of cyto-kinesis 1 (predicted)
ptpn11 GeneProduct ncbigene:333979
mapk3 GeneProduct ncbigene:399480
fos GeneProduct ncbigene:394198

References

  1. An overview of the c-MET signaling pathway. Organ SL, Tsao MS. Ther Adv Med Oncol. 2011 Nov;3(1 Suppl):S7–19. PubMed Europe PMC Scholia