Ethanol metabolism resulting in production of ROS by CYP2E1 (WP4265)
Mus musculus
Metabolism of Ethanol resulting in production of ROS by CYP2E1. Also includes a list of other CYP2E1 substrates and their metabolite outcomes. This pathway is also available for rat and human.
Authors
Ado , Egon Willighagen , Marvin Martens , and Friederike EhrhartActivity
Discuss this pathway
Check for ongoing discussions or start your own.
Cited In
Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.
Organisms
Mus musculusCommunities
Annotations
Pathway Ontology
xenobiotic metabolic pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| staurosporine | Metabolite | chebi:57491 | |
| Fluoride | Metabolite | chebi:17051 | |
| Enflurane | Metabolite | hmdb:HMDB0014373 | |
| acetaldehyde | Metabolite | chebi:15343 | |
| ethanol | Metabolite | chebi:16236 | |
| Halothane | Metabolite | chebi:5615 | |
| Vitamin C | Metabolite | chebi:38290 | |
| Diallyl sulfide | Metabolite | chebi:4489 | |
| Sevoflurane | Metabolite | chebi:9130 | |
| 6-Hydroxychlorzoxazone | Metabolite | hmdb:HMDB0060998 | |
| Isoflurane | Metabolite | chebi:6015 | |
| NAPQI | Metabolite | chebi:29132 | |
| Methoxyflurane | Metabolite | chebi:6843 | |
| Acetaminophen | Metabolite | chebi:46195 | |
| Chlorzoxazone | Metabolite | chebi:3655 | |
| U0126 | Metabolite | chebi:90693 | |
| Trifluoroacetic acid | Metabolite | chebi:45892 | |
| Mapk8 | GeneProduct | ensembl:ENSMUSG00000021936 | |
| Cyp2e1 | GeneProduct | ensembl:ENSMUSG00000025479 | |
| Sp1 | GeneProduct | ensembl:ENSMUSG00000001280 | |
| Map2k2 | GeneProduct | ensembl:ENSMUSG00000035027 | |
| Maff | GeneProduct | ensembl:ENSMUSG00000042622 | |
| Mafg | GeneProduct | ensembl:ENSMUSG00000051510 | |
| Map2k1 | GeneProduct | ensembl:ENSMUSG00000004936 | |
| Mafk | GeneProduct | ensembl:ENSMUSG00000018143 | |
| Nfe2l2 | GeneProduct | ensembl:ENSMUSG00000015839 | |
| Protein kinase C | Protein | uniprot:Q1MX41 |
References
- Regulation of cytochrome P450 2e1 expression by ethanol: role of oxidative stress-mediated pkc/jnk/sp1 pathway. Jin M, Ande A, Kumar A, Kumar S. Cell Death Dis. 2013 Mar 21;4(3):e554. PubMed Europe PMC Scholia