G1 to S cell cycle control (WP413)

Mus musculus

Open in new tab
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads
In the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding CKIs mediated by the p53 protein, whereas the p53-independent mechanisms inhibit CDKs through the inhibitory T14Y15 phosphorylation of Cdk2. Failure of DNA damage checkpoints in G1 leads to mutagenic replication of damaged templates and other replication defects. Source: Reactome http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&FOCUS_SPECIES=Homo%20sapiens&ID=69615&

Authors

Alexander C. Zambon , Nathan Salomonis , Kristina Hanspers , Christine Chichester , and Martina Summer-Kutmon

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Mus musculus

Communities

Annotations

Pathway Ontology

G1/S DNA damage checkpoint pathway

Participants

Label Type Compact URI Comment
Cdk4 GeneProduct ncbigene:12567
Cdk6 GeneProduct ncbigene:12571
Ccnd1 GeneProduct ncbigene:12443
Ccnd2 GeneProduct ncbigene:12444
Ccnd3 GeneProduct ncbigene:12445
Cdkn1a GeneProduct ncbigene:12575
Cdkn1b GeneProduct ncbigene:12576
Cdk7 GeneProduct ncbigene:12572
Ccnh GeneProduct ncbigene:66671
E2f1 GeneProduct ncbigene:13555
E2f2 GeneProduct ncbigene:242705
E2f3 GeneProduct ncbigene:13557
Rbl1 GeneProduct ncbigene:19650
Rb1 GeneProduct ncbigene:19645
E2f4 GeneProduct ncbigene:104394
E2f5 GeneProduct ncbigene:13559
E2f6 GeneProduct ncbigene:50496
Tfdp1 GeneProduct ncbigene:21781
Tfdp2 GeneProduct ncbigene:211586
Cdk2 GeneProduct ncbigene:12566
Ccne1 GeneProduct ncbigene:12447
Ccne2 GeneProduct ncbigene:12448
Pole2 GeneProduct ncbigene:18974
Pole GeneProduct ncbigene:18973
Cdc25a GeneProduct ncbigene:12530
Wee1 GeneProduct ncbigene:22390
Pkmyt1 GeneProduct ncbigene:268930
Cdc2a GeneProduct ncbigene:12534
Cdk4 GeneProduct ncbigene:12567
Cdk6 GeneProduct ncbigene:12571
Cdk7 GeneProduct ncbigene:12572
Cdc45l GeneProduct ncbigene:12544
Rpa2 GeneProduct ncbigene:19891
Rpa3 GeneProduct ncbigene:68240
Rpa1 GeneProduct ncbigene:68275
Mcm2 GeneProduct ncbigene:17216
Mcm3 GeneProduct ncbigene:17215
Mcm4 GeneProduct ncbigene:17217
Mcm5 GeneProduct ncbigene:17218
Mcm6 GeneProduct ncbigene:17219
Mcm7 GeneProduct ncbigene:17220
Orc1l GeneProduct ncbigene:18392
Orc2l GeneProduct ncbigene:18393
Orc3l GeneProduct ncbigene:50793
Orc4l GeneProduct ncbigene:26428
Orc5l GeneProduct ncbigene:26429
Orc6l GeneProduct ncbigene:56452
Prim1 GeneProduct ncbigene:19075
Prim2 GeneProduct ncbigene:19076
Pola2 GeneProduct ncbigene:18969
Pcna GeneProduct ncbigene:18538
Trp53 GeneProduct ncbigene:22059
Gadd45a GeneProduct ncbigene:13197
Mdm2 GeneProduct ncbigene:17246
Cdkn2c GeneProduct ncbigene:12580
Cdkn2b GeneProduct ncbigene:12579
Cdkn2d GeneProduct ncbigene:12581
Cdkn2a GeneProduct ncbigene:12578
Cdc2a GeneProduct ncbigene:12534
Ccna1 GeneProduct ncbigene:12427
Ccnb1-rs1 GeneProduct ncbigene:12429
Atm GeneProduct ncbigene:11920
Cdkn1c GeneProduct ncbigene:12577
Ccng2 GeneProduct ncbigene:12452
Myc GeneProduct ncbigene:17869
Mnat1 GeneProduct ncbigene:17420

References

  1. GADD45 regulates G2/M arrest, DNA repair, and cell death in keratinocytes following ultraviolet exposure. Maeda T, Hanna AN, Sim AB, Chua PP, Chong MT, Tron VA. J Invest Dermatol. 2002 Jul;119(1):22–6. PubMed Europe PMC Scholia