Trehalose anabolism (WP398)

Saccharomyces cerevisiae

Open in new tab Open in Newt (SBGN)
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads
Trehalose is a storage carbohydrate that can either be synthesized or obtained from the external environment. To be utilized as a carbon source, trehalase (EC:3.2.1.28) must convert trehalose and water into two molecules of glucose. S. cerevisiae has two trehalase enzymes, one is an acid trehalase encoded by ATH1 and the other is a neutral trehalase encoded by NTH1. The name "acid" or "neutral" are based on the optimal pH of each enzyme (pH 4.5-5.0 and pH 6.8-7.0, respectively).

Authors

Meredith Braymer , Daniela Digles , Egon Willighagen , Denise Slenter , and Eric Weitz

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Saccharomyces cerevisiae

Communities

Annotations

Pathway Ontology

trehalose biosynthetic pathway

Participants

Label Type Compact URI Comment
UDP Metabolite chebi:17659
UTP Metabolite chebi:46398
alpha,alpha-trehalose 6-phosphate Metabolite wikidata:Q27102967
H2O Metabolite chebi:15377
UDP-D-glucose Metabolite chebi:46229
pyrophosphate Metabolite cas:2466-09-3
glucose-1-phosphate Metabolite chebi:16077
beta-D-Glucose Metabolite chebi:15903
phosphate Metabolite cas:14265-44-2
glucose-6-phosphate Metabolite chebi:75150
trehalose Metabolite cas:99-20-7
PGM2 GeneProduct sgd:S000004711
UGP1 GeneProduct sgd:S000001518
TPS2 GeneProduct sgd:S000002481
TSL1 GeneProduct sgd:S000004566
PGM1 GeneProduct sgd:S000001610
TPS3 GeneProduct sgd:S000004874
TPS1 GeneProduct sgd:S000000330
YHL012W GeneProduct sgd:S000001004
ATH1 GeneProduct ensembl:YPR026W acid trehalase
NTH1 GeneProduct ensembl:YDR001C neutral trehalase

References

  1. Reserve carbohydrates metabolism in the yeast Saccharomyces cerevisiae. François J, Parrou JL. FEMS Microbiol Rev. 2001 Jan;25(1):125–45. PubMed Europe PMC Scholia