Copper homeostasis (WP3962)

Caenorhabditis elegans

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Adapted from figure 7 from Chun et al (see Bibliography). Cu homeostasis in worms is maintained by distinctly localized intestinal CUA-1 isoforms. A model of Cu homeostasis in C. elegans is shown. Dietary Cu ions are transported from the lumen of the intestine to the enterocytes by an unidentified Cu importer, and CUC-1 delivers Cu to CUA-1. Under basal Cu or Cu-deficient conditions, CUA-1.1 isoform localizes to the basolateral membrane and Golgi to either export Cu ions to peripheral tissues, or to direct Cu into the secretory pathway. CUA-1.2 consistently localizes to the basolateral membrane of enterocytes regardless of Cu conditions. CUA-1.1 is redistributed to the gut-granule membranes in response to elevated Cu levels in order to promote Cu detoxification in C. elegans."

Authors

Karen Yook , Kristina Hanspers , and Egon Willighagen

Activity

last edited

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Organisms

Caenorhabditis elegans

Communities

WormBase

Annotations

Pathway Ontology

copper homeostasis pathway

Cell Type Ontology

intestinal epithelial cell

Participants

Label Type Compact URI Comment
Cu Metabolite chebi:23378
elementalcopper Metabolite chebi:23378
CUC-1 GeneProduct ensembl:WBGene00000835
CUA-1.1 GeneProduct ensembl:WBGene00000834
CUA-1.1 GeneProduct ensembl:WBGene00000834 CUA-1.1 isoform localizes to the basolateral membrane and Golgi to either export Cu ions to peripheral tissues, or to direct Cu into the secretory pathway.
CUA-1.2 GeneProduct ensembl:WBGene00000834 'CUA-1.2 consistently localizes to the basolateral membrane of enterocytes regardless of Cu conditions. ' Evidence: 'Confocal images of transgenic animals [Pvha-6::CUA-1.2::GFP::unc-54 3’UTR] expressing CUA-1.2::GFP in the intestine in the presence of 50 μM of supplemental Cu or BCS.'
CUA-1.2 GeneProduct ensembl:WBGene00000834 'CUA-1.2 consistently localizes to the basolateral membrane of enterocytes regardless of Cu conditions. '

References

  1. The Intestinal Copper Exporter CUA-1 Is Required for Systemic Copper Homeostasis in Caenorhabditis elegans. Chun H, Sharma AK, Lee J, Chan J, Jia S, Kim BE. J Biol Chem. 2017 Jan 6;292(1):1–14. PubMed Europe PMC Scholia