Septum site determination (WP3538)
Escherichia coli
In Escherichia coli, division site selection is regulated in part by the Min-protein system. Oscillations of the Min proteins from pole to pole every approximately 40 sec have been revealed by in vivo studies of GFP fusions. The dynamic oscillatory structures produced by the Min proteins, including a ring of MinE protein, compact polar zones of MinD, and zebra-striped oscillations in filamentous cells, remain unexplained. We show that the Min oscillations, including mutant phenotypes, can be accounted for by in vitro-observed interactions involving MinD and MinE, with a crucial role played by the rate of nucleotide exchange. Recent discoveries suggest that protein oscillations may play a general role in proper chromosome and plasmid partitioning. (Huang KC et al. 2003)
Authors
Friederike Ehrhart and Linda RieswijkActivity
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Organisms
Escherichia coliCommunities
Annotations
Pathway Ontology
regulatory pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Phosphate | Metabolite | hmdb:HMDB0001429 | |
| ADP | Metabolite | hmdb:HMDB0001341 | |
| ATP | Metabolite | hmdb:HMDB0000538 | |
| MinD | Protein | uniprot:P0AEZ3 | |
| MinE | Protein | uniprot:P0A734 |
References
- Dynamic structures in Escherichia coli: spontaneous formation of MinE rings and MinD polar zones. Huang KC, Meir Y, Wingreen NS. Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12724–8. PubMed Europe PMC Scholia