Synthesis and degradation of ketone bodies (WP349)

Rattus norvegicus

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Ketone bodies are three water-soluble compounds that are produced as by-products when fatty acids are broken down for energy in the liver and kidney. They are used as a source of energy in the heart and brain. In the brain, they are a vital source of energy during fasting. Source: [[wikipedia:Ketone_bodies|Wikipedia]]

Authors

Niradiz Reyes , Thomas Kelder , Kristina Hanspers , Susan Coort , Daniela Digles , and Eric Weitz

Activity

last edited

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Organisms

Rattus norvegicus

Communities

Annotations

Pathway Ontology

ketone bodies metabolic pathway

Participants

Label Type Compact URI Comment
Acetyl-CoA Metabolite cas:72-89-9
Acetoacetyl-CoA Metabolite cas:1420-36-6
3-Hydroxybutyric acid Metabolite hmdb:HMDB0000357
Acetoacetic acid Metabolite hmdb:HMDB0000060
3-Hydroxy-3-methylglutaryl-CoA Metabolite cas:1553-55-5
Hmgcl GeneProduct ncbigene:79238
Acat1 GeneProduct ncbigene:25014
Hmgcs2 GeneProduct ncbigene:24450
Oxct1 GeneProduct ncbigene:690163
Bdh1 GeneProduct ncbigene:117099

References

  1. Pathways and control of ketone body metabolism: on the fringe of lipid biochemistry. Fukao T, Lopaschuk GD, Mitchell GA. Prostaglandins Leukot Essent Fatty Acids. 2004 Mar;70(3):243–51. PubMed Europe PMC Scholia