Endothelin pathways (WP3246)

Bos taurus

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Endothelin-1 is a bicyclic 21 amino acid peptide, produced primarily in the endothelium. It is a potent stimulus of long-lasting and persistent vasoconstriction. It also has a role as a stimulus of inflammation, oxidative stress and cellular proliferation.

Authors

Martina Summer-Kutmon , Eric Weitz , and Egon Willighagen

Activity

last edited pathway curation

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Cited In

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Organisms

Bos taurus

Communities

Renal Genomics Pathways

Annotations

Pathway Ontology

G protein mediated signaling pathway via Galphai family calcium/calmodulin dependent signaling pathway G protein mediated signaling pathway via Galphas family endothelin signaling pathway Ras superfamily mediated signaling pathway G protein mediated signaling pathway via Galphaq family

Disease Ontology

benign essential hypertension hypertension

Cell Type Ontology

smooth muscle cell blood vessel endothelial cell

Participants

Label Type Compact URI Comment
GTP Metabolite hmdb:HMDB0001440
L-Arginine Metabolite hmdb:HMDB0000517
K+ Metabolite hmdb:HMDB0000586
cGMP Metabolite hmdb:HMDB0001314
NO Metabolite hmdb:HMDB0003378
ATP Metabolite hmdb:HMDB0001532
cAMP Metabolite hmdb:HMDB0000058
Citrulline Metabolite hmdb:HMDB0000904
Arachidonic acid Metabolite hmdb:HMDB0001043
IP3 Metabolite hmdb:HMDB0001059
DAG Metabolite hmdb:HMDB0007008
Ca2+ Metabolite hmdb:HMDB0000464
PIP2 Metabolite hmdb:HMDB0010032
RAMP1 GeneProduct ensembl:ENSBTAG00000011534 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000132329
NPY1R GeneProduct ensembl:ENSBTAG00000047586 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000164128
CT GeneProduct ensembl:ENSBTAG00000047380 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000110680
ATP2A2 GeneProduct ensembl:ENSBTAG00000001398 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000174437
RIIAD1 GeneProduct ensembl:ENSBTAG00000032733 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000178796
ADCY10 GeneProduct ensembl:ENSBTAG00000001052 adenylate cyclase
HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000143199
COII GeneProduct ensembl:ENSBTAG00000043556 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4513
ADRA1A GeneProduct ensembl:ENSBTAG00000031632 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000120907
NPY GeneProduct ensembl:ENSBTAG00000004503 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000122585
CALCRL GeneProduct ensembl:ENSBTAG00000008483 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000064989
PTGIR GeneProduct ensembl:ENSBTAG00000014585 Prostaglandin I2 Receptor
HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000160013
NOS3 GeneProduct ensembl:ENSBTAG00000017680 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000164867
EDN1 GeneProduct ensembl:ENSBTAG00000008096 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000078401
ECE1 GeneProduct ensembl:ENSBTAG00000002977 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000117298
CNN1 GeneProduct ensembl:ENSBTAG00000011207 Calponin; tonically inhibits the ATPase activity of myosin in smooth muscle
HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000130176
PRKCA GeneProduct ensembl:ENSBTAG00000001061 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000154229
GNA15 GeneProduct ensembl:ENSBTAG00000019988 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000060558
MYL1 GeneProduct ensembl:ENSBTAG00000009707 myosine light chain
HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000168530
MAP2K1 GeneProduct ensembl:ENSBTAG00000033983 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000169032
EDNRA GeneProduct ensembl:ENSBTAG00000013674 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000151617
MYLK GeneProduct ensembl:ENSBTAG00000014567 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000065534
MAPK1 GeneProduct ensembl:ENSBTAG00000010312 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100030
EDNRB GeneProduct ensembl:ENSBTAG00000005299 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136160
RAF1 GeneProduct ensembl:ENSBTAG00000045748 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000132155
PLCB1 GeneProduct ensembl:ENSBTAG00000008338 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000182621
CAD GeneProduct ensembl:ENSBTAG00000017894 Calmodulin binding protein; tonically inhibits the ATPase activity of myosin in smoothe muscle; mediating factor for Ca2+ dependent inhibition of smooth muscle contraction
HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000084774
GNB5 GeneProduct ensembl:ENSBTAG00000003762 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000069966
GNG13 GeneProduct ensembl:ENSBTAG00000033526 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000127588
GNAS GeneProduct ensembl:ENSBTAG00000017475 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000087460
ADRB1 GeneProduct ensembl:ENSBTAG00000001242 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000043591
GNAI1 GeneProduct ensembl:ENSBTAG00000002714 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000127955

References