Serotonin receptor 2 and ELK-SRF / GATA4 signaling (WP3242)
Bos taurus
This pathway depicts the downstream signaling of serotonin via receptors 2A, 2B, and 2C, resulting in the activation of ELK-SRF and GATA4.
Authors
Martina Summer-Kutmon , Egon Willighagen , Eric Weitz , and Alex PicoActivity
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Organisms
Bos taurusCommunities
Annotations
Cell Type Ontology
neuronPathway Ontology
serotonin signaling pathwayLabel | Type | Compact URI | Comment |
---|---|---|---|
CALCIUM | Metabolite | cas:7440-70-2 | |
serotonin | Metabolite | cas:50-67-9 | |
1,4,5-Insp3 | Metabolite | cas:85166-31-0 | 1,4,5-Insp3 |
ITPR1 | GeneProduct | ensembl:ENSBTAG00000020455 | inositol 1,4,5-triphosphate receptor 1HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3708 |
NRAS | GeneProduct | ensembl:ENSBTAG00000046797 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4893 |
HRAS | GeneProduct | ensembl:ENSBTAG00000046644 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3265 |
RAF1 | GeneProduct | ensembl:ENSBTAG00000045748 | v-raf-leukemia viral oncogene 1HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5894 |
ELK1 | GeneProduct | ensembl:ENSBTAG00000015817 | ELK1, member of ETS oncogene familyHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2002 |
MAPK1 | GeneProduct | ensembl:ENSBTAG00000010312 | mitogen activated protein kinase 1HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:MAPK1 |
MAPKAPK2 | GeneProduct | ensembl:ENSBTAG00000038107 | MAP kinase-activated protein kinase 2HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9261 |
MAPK3 | GeneProduct | ensembl:ENSBTAG00000016156 | mitogen activated protein kinase 3HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5595 |
HTR2A | GeneProduct | ensembl:ENSBTAG00000013498 | 5-hydroxytryptamine (serotonin) receptor 2AHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3356 |
GATA4 | GeneProduct | ensembl:ENSBTAG00000005425 | GATA-binding protein 4/5/6HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2626 |
MAP2K2 | GeneProduct | ensembl:ENSBTAG00000024450 | mitogen activated protein kinase kinase 2HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5605 |
RASGRF1 | GeneProduct | ensembl:ENSBTAG00000019940 | RAS protein-specific guanine nucleotide-releasing factor 1HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5923 |
MAP2K1 | GeneProduct | ensembl:ENSBTAG00000033983 | mitogen activated protein kinase kinase 1HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5604 |
RASGRP1 | GeneProduct | ensembl:ENSBTAG00000021872 | RAS guanyl releasing protein 1HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10125 |
5HTR2B | GeneProduct | ensembl:ENSBTAG00000039772 | 5-hydroxytryptamine (serotonin) receptor 2BHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3357 |
ELK4 | GeneProduct | ensembl:ENSBTAG00000004953 | ETS domain-containing protein Elk-4 (SRF accessory protein 1)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2005 |
GNAQ | GeneProduct | ensembl:ENSBTAG00000009789 | guanine nucleotide binding protein, alpha q polypeptideHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2776 |
SRF | GeneProduct | ensembl:ENSBTAG00000012777 | serum response factorHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6722 |
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