Iron uptake and transport (WP3217)

Bos taurus

The transport of iron between cells is mediated by transferrin. However, iron can also enter and leave cells not only by itself, but also in the form of heme and siderophores. When entering the cell via the main path (by transferrin endocytosis), its goal is not the (still elusive) chelated iron pool in the cytosol nor the lysosomes but the mitochondria, where heme is synthesized and iron-sulfur clusters are assembled (Kurz et al,2008, Hower et al 2009, Richardson et al 2010).Original Pathway at Reactome: http://www.reactome.org/PathwayBrowser/#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=917937

Authors

Martina Summer-Kutmon , Denise Slenter , and Egon Willighagen

Activity

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

iron transport pathway

Participants

Label Type Compact URI Comment
Ca2+ Metabolite chebi:29108
H+ Metabolite chebi:15378
ATP Metabolite chebi:15422
Cl- Metabolite chebi:17996
ADP Metabolite chebi:16761
APLs Metabolite reactome:REACT_26709
Fe2+ Metabolite chebi:18248
FeHM Metabolite chebi:36144
Na+ Metabolite pubchem.compound:923
Fe3+ [extracellularregion] Metabolite chebi:29034
Pi Metabolite chebi:18367
Gly [extracellularregion] Metabolite chebi:15428
H2O Metabolite chebi:15377
K+ Metabolite chebi:29103
heme [plasmamembrane] Metabolite chebi:17627
Fe3+ [endosomemembrane] Metabolite chebi:29034
Fe3+ Metabolite chebi:29034
NADPH Metabolite chebi:16474
O2 Metabolite chebi:15379
Urate Metabolite chebi:17775
Cu2+ [extracellularregion] Metabolite chebi:29036
e- Metabolite chebi:10545
GABA [extracellularregion] Metabolite chebi:16865
Na+ Metabolite chebi:29101
Cu2+ Metabolite chebi:29036
NAADP Metabolite chebi:76072
5HT [extracellularregion] Metabolite chebi:28790
HCO3- Metabolite chebi:17544
heme Metabolite chebi:17627
Mg2+ [Golgimembrane] Metabolite chebi:18420
PPi Metabolite chebi:29888
APLs Metabolite reactome:REACT_26259
H+ [extracellularregion] Metabolite chebi:15378
CO Metabolite chebi:17245
amiloride Metabolite chebi:2639
BV Metabolite chebi:17033
Cu2+ [plasmamembrane] Metabolite chebi:29036
NSAID Metabolite chebi:35475
AMP Metabolite chebi:16027
NADP+ Metabolite chebi:18009
Li+ Metabolite pubchem.compound:28486
FLVCR1 Protein ensembl:ENSBTAG00000015974 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q9Y5Y0
BSND Protein ensembl:ENSBTAG00000013241 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q8WZ55
ATP1B3 Protein ensembl:ENSBTAG00000014140 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P54709
TF Protein ensembl:ENSBTAG00000007273 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P02787
ATP6V1E1 Protein ensembl:ENSBTAG00000014238 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P36543
SLC9B2 Protein ensembl:ENSBTAG00000040088 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q86UD5
ASIC5 Protein ensembl:ENSBTAG00000044109 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q9NY37
ASIC1 Protein ensembl:ENSBTAG00000000970 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P78348
FXYD7 Protein ensembl:ENSBTAG00000018326 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P58549
GABRB2 Protein ensembl:ENSBTAG00000018585 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P47870
ATP4A Protein ensembl:ENSBTAG00000045598 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P20648
HTR3D Protein ensembl:ENSBTAG00000039011 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q70Z44
ATP6V1C2 Protein ensembl:ENSBTAG00000001927 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q8NEY4
TFRC Protein ensembl:ENSBTAG00000032719 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P02786
CLCNKA [plasmamembrane] Protein ensembl:ENSBTAG00000034674 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P51800
SCNN1G Protein ensembl:ENSBTAG00000010163 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P51170
ATP6V0D2 Protein ensembl:ENSBTAG00000021092 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q8N8Y2
SCNN1B Protein ensembl:ENSBTAG00000012290 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P51168
GABRB3 Protein ensembl:ENSBTAG00000013422 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P28472
ATP1B2 Protein ensembl:ENSBTAG00000013680 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P14415
TRDN Protein ensembl:ENSBTAG00000038849 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q13061
RYR1 Protein ensembl:ENSBTAG00000006999 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P21817
SLC11A2 Protein ensembl:ENSBTAG00000002355 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P49281
ATP6V1G3 Protein ensembl:ENSBTAG00000019890 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q96LB4
GABRA2 Protein ensembl:ENSBTAG00000011817 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P47869
ATP6V0C Protein ensembl:ENSBTAG00000026428 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P27449
TCIRG1 Protein ensembl:ENSBTAG00000000292 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q13488
ATP6V1D Protein ensembl:ENSBTAG00000016309 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q9Y5K8
ATP4B Protein ensembl:ENSBTAG00000019961 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P51164
ATP6V0E1 Protein ensembl:ENSBTAG00000015100 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:O15342
SLC17A3 Protein ensembl:ENSBTAG00000003797 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:O00476
SCNN1D Protein ensembl:ENSBTAG00000017674 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P51172
ATP2C2 Protein ensembl:ENSBTAG00000000945 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:O75185
HTR3B Protein ensembl:ENSBTAG00000031330 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:O95264
RAF1 Protein ensembl:ENSBTAG00000045748 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P04049
GABRA3 Protein ensembl:ENSBTAG00000006691 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P34903
RYR3 Protein ensembl:ENSBTAG00000025642 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q15413
OSTM1 Protein ensembl:ENSBTAG00000010134 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q86WC4
ATP6V0A2 Protein ensembl:ENSBTAG00000007272 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q9Y487
ARHGEF9 Protein ensembl:ENSBTAG00000012729 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:O43307
TSC22D3 Protein ensembl:ENSBTAG00000045877 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q99576
GABRB1 Protein ensembl:ENSBTAG00000017837 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P18505
GABRG2 Protein ensembl:ENSBTAG00000010251 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P18507
CLCN7 Protein ensembl:ENSBTAG00000015889 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P51798
NEDD4L Protein ensembl:ENSBTAG00000005412 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q96PU5
ATP2C1 Protein ensembl:ENSBTAG00000011626 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P98194
ATP1A4 Protein ensembl:ENSBTAG00000038523 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q13733
ATP1B1 Protein ensembl:ENSBTAG00000002688 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P05026
FXYD1 Protein ensembl:ENSBTAG00000017816 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:O00168
ATP6V1H Protein ensembl:ENSBTAG00000003450 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q9UI12
ATP6V0E2 Protein ensembl:ENSBTAG00000006022 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q8NHE4
ATP7A Protein ensembl:ENSBTAG00000010018 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q04656
ATP6V1A Protein ensembl:ENSBTAG00000002703 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P38606
STEAP3 Protein ensembl:ENSBTAG00000007111 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q658P3
GABRA4 Protein ensembl:ENSBTAG00000016645 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P48169
ATP1A1 Protein ensembl:ENSBTAG00000001246 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P05023
ATP6V1G2 Protein ensembl:ENSBTAG00000014491 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:O95670
GABRR2 Protein ensembl:ENSBTAG00000018435 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P28476
ATP6V1E2 Protein ensembl:ENSBTAG00000013734 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q96A05
CYBRD1 Protein ensembl:ENSBTAG00000007898 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q53TN4
ATP6V0D1 Protein ensembl:ENSBTAG00000014553 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P61421
SLC40A1 Protein ensembl:ENSBTAG00000010498 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q9NP59
SLC46A1 Protein ensembl:ENSBTAG00000002817 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q96NT5
GABRA6 Protein ensembl:ENSBTAG00000013262 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q16445
ACCN3 Protein ensembl:ENSBTAG00000007762 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q9UHC3
CLCN3 Protein ensembl:ENSBTAG00000020130 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P51790
SGK2 Protein ensembl:ENSBTAG00000021033 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q9HBY8
FTL [cytosol] Protein ensembl:ENSBTAG00000019709 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P02792
SGK1 Protein ensembl:ENSBTAG00000004269 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:O00141
ATP6V0A4 Protein ensembl:ENSBTAG00000004263 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q9HBG4
ATP6V1B1 Protein ensembl:ENSBTAG00000010620 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P15313
FXYD6 Protein ensembl:ENSBTAG00000014354 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q9H0Q3
HTR3E Protein ensembl:ENSBTAG00000040304 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:A5X5Y0
ATP7B Protein ensembl:ENSBTAG00000010353 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P35670
GABRR1 Protein ensembl:ENSBTAG00000011672 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P24046
ATP6V1B2 Protein ensembl:ENSBTAG00000018646 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P21281
ATP1A3 Protein ensembl:ENSBTAG00000018635 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P13637
ATP6V1G1 Protein ensembl:ENSBTAG00000000203 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:O75348
SCNN1A Protein ensembl:ENSBTAG00000002631 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P37088
CLCNKB [plasmamembrane] Protein ensembl:ENSBTAG00000034674 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P51801
ATP1A2 Protein ensembl:ENSBTAG00000010551 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P50993
SLC9C1 Protein ensembl:ENSBTAG00000019332 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q4G0N8
CLIC2 Protein ensembl:ENSBTAG00000010948 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:O15247
GABRA1 Protein ensembl:ENSBTAG00000030286 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P14867
ATP6V1C1 Protein ensembl:ENSBTAG00000013513 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P21283
UNC79 Protein ensembl:ENSBTAG00000008017 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q9P2D8
RYR2 Protein ensembl:ENSBTAG00000022886 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q92736
GLRB Protein ensembl:ENSBTAG00000021764 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P48167
HTR3A Protein ensembl:ENSBTAG00000010791 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P46098
ASIC4 Protein ensembl:ENSBTAG00000020537 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q96FT7
FXYD3 Protein ensembl:ENSBTAG00000040005 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q14802
CLCN2 Protein ensembl:ENSBTAG00000012284 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P51788
CLCN1 Protein ensembl:ENSBTAG00000009182 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P35523
GABRA5 Protein ensembl:ENSBTAG00000003392 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P31644
FXYD2 Protein ensembl:ENSBTAG00000009828 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P54710
ATP6V1F [cytosol] Protein ensembl:ENSBTAG00000045497 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q16864
UNC80 Protein ensembl:ENSBTAG00000015415 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q8N2C7
ATP12A Protein ensembl:ENSBTAG00000014486 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P54707
WWP1 Protein ensembl:ENSBTAG00000015720 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q9H0M0
NALCN Protein ensembl:ENSBTAG00000037786 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q8IZF0
MCOLN1 Protein ensembl:ENSBTAG00000005592 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q9GZU1
ATP6V0B Protein ensembl:ENSBTAG00000018889 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q99437
HEPH Protein ensembl:ENSBTAG00000047416 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q9BQS7
ABCG2 Protein ensembl:ENSBTAG00000017704 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q9UNQ0
CP Protein ensembl:ENSBTAG00000012164 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P00450
ATP6V0A1 Protein ensembl:ENSBTAG00000019218 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q93050

References

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  22. Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes. Harding C, Heuser J, Stahl P. J Cell Biol. 1983 Aug;97(2):329–39. PubMed Europe PMC Scholia
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  24. Molecular cloning of the cDNA encoding human skeletal muscle triadin and its localisation to chromosome 6q22-6q23. Taske NL, Eyre HJ, O’Brien RO, Sutherland GR, Denborough MA, Foster PS. Eur J Biochem. 1995 Oct 1;233(1):258–65. PubMed Europe PMC Scholia
  25. The Wilson disease gene: spectrum of mutations and their consequences. Thomas GR, Forbes JR, Roberts EA, Walshe JM, Cox DW. Nat Genet. 1995 Feb;9(2):210–7. PubMed Europe PMC Scholia
  26. Characterization of a human and murine gene (CLCN3) sharing similarities to voltage-gated chloride channels and to a yeast integral membrane protein. Borsani G, Rugarli EI, Taglialatela M, Wong C, Ballabio A. Genomics. 1995 May 1;27(1):131–41. PubMed Europe PMC Scholia
  27. Localization and identification of Ca2+ATPases in highly purified human platelet plasma and intracellular membranes. Evidence that the monoclonal antibody PL/IM 430 recognizes the SERCA 3 Ca2+ATPase in human platelets. Bokkala S, el-Daher SS, Kakkar VV, Wuytack F, Authi KS. Biochem J. 1995 Mar 15;306 ( Pt 3)(Pt 3):837–42. PubMed Europe PMC Scholia
  28. Cloning of a putative human voltage-gated chloride channel (CIC-2) cDNA widely expressed in human tissues. Cid LP, Montrose-Rafizadeh C, Smith DI, Guggino WB, Cutting GR. Hum Mol Genet. 1995 Mar;4(3):407–13. PubMed Europe PMC Scholia
  29. Two highly homologous members of the ClC chloride channel family in both rat and human kidney. Kieferle S, Fong P, Bens M, Vandewalle A, Jentsch TJ. Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):6943–7. PubMed Europe PMC Scholia
  30. Cloning and characterization of the entire cDNA encoded by ATP1AL1--a member of the human Na,K/H,K-ATPase gene family. Grishin AV, Sverdlov VE, Kostina MB, Modyanov NN. FEBS Lett. 1994 Jul 25;349(1):144–50. PubMed Europe PMC Scholia
  31. Multimeric structure of ClC-1 chloride channel revealed by mutations in dominant myotonia congenita (Thomsen). Steinmeyer K, Lorenz C, Pusch M, Koch MC, Jentsch TJ. EMBO J. 1994 Feb 15;13(4):737–43. PubMed Europe PMC Scholia
  32. Role of the beta subunit in determining the pharmacology of human gamma-aminobutyric acid type A receptors. Hadingham KL, Wingrove PB, Wafford KA, Bain C, Kemp JA, Palmer KJ, et al. Mol Pharmacol. 1993 Dec;44(6):1211–8. PubMed Europe PMC Scholia
  33. The Wilson disease gene is a putative copper transporting P-type ATPase similar to the Menkes gene. Bull PC, Thomas GR, Rommens JM, Forbes JR, Cox DW. Nat Genet. 1993 Dec;5(4):327–37. PubMed Europe PMC Scholia
  34. Antibodies to the human gamma 2 subunit of the gamma-aminobutyric acidA/benzodiazepine receptor. Khan ZU, Fernando LP, Escribá P, Busquets X, Mallet J, Miralles CP, et al. J Neurochem. 1993 Mar;60(3):961–71. PubMed Europe PMC Scholia
  35. Proton-sodium stoichiometry of NhaA, an electrogenic antiporter from Escherichia coli. Taglicht D, Padan E, Schuldiner S. J Biol Chem. 1993 Mar 15;268(8):5382–7. PubMed Europe PMC Scholia
  36. Cloning of cDNA sequences encoding human alpha 2 and alpha 3 gamma-aminobutyric acidA receptor subunits and characterization of the benzodiazepine pharmacology of recombinant alpha 1-, alpha 2-, alpha 3-, and alpha 5-containing human gamma-aminobutyric acidA receptors. Hadingham KL, Wingrove P, Le Bourdelles B, Palmer KJ, Ragan CI, Whiting PJ. Mol Pharmacol. 1993 Jun;43(6):970–5. PubMed Europe PMC Scholia
  37. Isolation of a candidate gene for Menkes disease that encodes a potential heavy metal binding protein. Chelly J, Tümer Z, Tønnesen T, Petterson A, Ishikawa-Brush Y, Tommerup N, et al. Nat Genet. 1993 Jan;3(1):14–9. PubMed Europe PMC Scholia
  38. Isolation of a candidate gene for Menkes disease and evidence that it encodes a copper-transporting ATPase. Vulpe C, Levinson B, Whitney S, Packman S, Gitschier J. Nat Genet. 1993 Jan;3(1):7–13. PubMed Europe PMC Scholia
  39. Spectrum of mutations in the major human skeletal muscle chloride channel gene (CLCN1) leading to myotonia. Meyer-Kleine C, Steinmeyer K, Ricker K, Jentsch TJ, Koch MC. Am J Hum Genet. 1995 Dec;57(6):1325–34. PubMed Europe PMC Scholia
  40. Cloning, tissue distribution, and intrarenal localization of ClC chloride channels in human kidney. Takeuchi Y, Uchida S, Marumo F, Sasaki S. Kidney Int. 1995 Nov;48(5):1497–503. PubMed Europe PMC Scholia
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