Apoptosis modulation and signaling (WP3148)

Bos taurus

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Apoptosis, or cell death program, can be activated by various mechanisms within the extrinsic and the intrinsic pathway. While activation of cell death receptors leads to the engagement of the extrinsic pathway, the intrinsic pathway is activated by mitochondria during cellular stress, both resulting in an activation of caspases. In the present pathway we emphasized the activation of caspases by those two pathways in pancreatic cancer (PDAC) cells. Please notice, that PDAC cells are so called type-II cells. In these cells the activation of cell death receptors is not sufficient to activated caspases. By cleavage of Bid, type-II cells activate the intrinsic pathway as “amplification loop”.

Authors

Martina Summer-Kutmon , Egon Willighagen , Denise Slenter , and Eric Weitz

Activity

last edited pathway curation

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Cited In

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

apoptotic cell death pathway

Participants

Label Type Compact URI Comment
Ca2+ Metabolite hmdb:HMDB0000464
MAPK8 GeneProduct ensembl:ENSBTAG00000007876 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:MAPK8
BIRC3 GeneProduct ensembl:ENSBTAG00000024918 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:BIRC3
IL1R1 GeneProduct ensembl:ENSBTAG00000005273 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:IL1R1
JUN GeneProduct ensembl:ENSBTAG00000004037 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:JUN
BIKBA GeneProduct ensembl:ENSBTAG00000016683 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:NFKBIA
DAXX GeneProduct ensembl:ENSBTAG00000016830 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:DAXX
BIRC5 GeneProduct ensembl:ENSBTAG00000013573 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:BIRC5
BCL2A1 GeneProduct ensembl:ENSBTAG00000000735 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:BCL2A1
CASP2 GeneProduct ensembl:ENSBTAG00000018159 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:835
APAF1 GeneProduct ensembl:ENSBTAG00000021661 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:APAF1
BOK GeneProduct ensembl:ENSBTAG00000008711 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:BOK
IKBKB GeneProduct ensembl:ENSBTAG00000007599 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:IKBKB
BCL2L11 GeneProduct ensembl:ENSBTAG00000024105 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:BCL2L11
BAX GeneProduct ensembl:ENSBTAG00000013340 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:BAX
TOLLIP GeneProduct ensembl:ENSBTAG00000008237 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:TOLLIP
TNFRSF11B GeneProduct ensembl:ENSBTAG00000007423 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:TNFRSF11B
IL1R2 GeneProduct ensembl:ENSBTAG00000006343 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:IL1R2
MADD GeneProduct ensembl:ENSBTAG00000021700 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:MADD
FLIP GeneProduct ensembl:ENSBTAG00000010998 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:CFLAR
AIFM1 GeneProduct ensembl:ENSBTAG00000006838 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9131
TRADD GeneProduct ensembl:ENSBTAG00000012642 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:TRADD
FASLG GeneProduct ensembl:ENSBTAG00000032808 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:FASLG
TRAF6 GeneProduct ensembl:ENSBTAG00000036009 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:TRAF6
CASP3 GeneProduct ensembl:ENSBTAG00000015874 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:CASP3
CASP13 GeneProduct ensembl:ENSBTAG00000020884 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:837
MAP3K14 GeneProduct ensembl:ENSBTAG00000007084 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:MAP3K14
TNFRSF25 GeneProduct ensembl:ENSBTAG00000006519 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:TNFRSF25
MAPK3 GeneProduct ensembl:ENSBTAG00000016156 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:MAPK3
MYD88 GeneProduct ensembl:ENSBTAG00000000563 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:MYD88
CASP6 GeneProduct ensembl:ENSBTAG00000012537 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:CASP6
TNFRSF1B GeneProduct ensembl:ENSBTAG00000024928 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:TNFRSF1B
CRADD GeneProduct ensembl:ENSBTAG00000005107 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:CRADD
SEPT4 GeneProduct ensembl:ENSBTAG00000015368 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:SEPT4
CASP9 GeneProduct ensembl:ENSBTAG00000002472 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:CASP9
CDKN2A GeneProduct ensembl:ENSBTAG00000034220 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:CDKN2A
BLK GeneProduct ensembl:ENSBTAG00000005049 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:BLK
BAG3 GeneProduct ensembl:ENSBTAG00000013641 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:BAG3
PIDD1 GeneProduct ensembl:ENSBTAG00000019634 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:55367
BIRC6 GeneProduct ensembl:ENSBTAG00000027932 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:BIRC6
CYCS GeneProduct ensembl:ENSBTAG00000022613 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:CYCS
MAP3K5 GeneProduct ensembl:ENSBTAG00000009065 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:MAP3K5
BAD GeneProduct ensembl:ENSBTAG00000012511 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:BAD
BCL2L2 GeneProduct ensembl:ENSBTAG00000019692 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:BCL2L2
BID2 GeneProduct ensembl:ENSBTAG00000013988 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:BID
TP53 GeneProduct ensembl:ENSBTAG00000001069 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7157
CASP7 GeneProduct ensembl:ENSBTAG00000006615 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:CASP7
TNFRSF1A GeneProduct ensembl:ENSBTAG00000004211 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:TNFRSF1A
HRK GeneProduct ensembl:ENSBTAG00000047484 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:HRK
PRKD1 GeneProduct ensembl:ENSBTAG00000012789 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5587
HN1 GeneProduct ensembl:ENSBTAG00000030170 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:HN1
NAIP GeneProduct ensembl:ENSBTAG00000003326 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4671
CAPNS1 GeneProduct ensembl:ENSBTAG00000014872 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:CAPNS1
AIFM2 GeneProduct ensembl:ENSBTAG00000001165 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:84883
MCL1 GeneProduct ensembl:ENSBTAG00000031396 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:MCL1
BMF GeneProduct ensembl:ENSBTAG00000012180 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:BMF
TNFRSF6B GeneProduct ensembl:ENSBTAG00000027407 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:TNFRSF6B
PTRH2 GeneProduct ensembl:ENSBTAG00000016710 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:PTRH2
RIPK1 GeneProduct ensembl:ENSBTAG00000006378 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8737
PTPN13 GeneProduct ensembl:ENSBTAG00000014947 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:PTPN13
TNFRSF10D GeneProduct ensembl:ENSBTAG00000047389 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:TNFRSF10A
ENDOG GeneProduct ensembl:ENSBTAG00000012484 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:ENDOG
CASP2 GeneProduct ensembl:ENSBTAG00000018159 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:CASP2
TNFSF10 GeneProduct ensembl:ENSBTAG00000018994 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:TNFSF10
BAK1 GeneProduct ensembl:ENSBTAG00000000428 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:BAK1
HTRA2 GeneProduct ensembl:ENSBTAG00000020124 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:HTRA2
DFFA GeneProduct ensembl:ENSBTAG00000013535 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:DFFA
BNIP3 GeneProduct ensembl:ENSBTAG00000017804 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:BNIP3
PEA15 GeneProduct ensembl:ENSBTAG00000005793 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8682
FOS GeneProduct ensembl:ENSBTAG00000004322 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:FOS
Bcl-B GeneProduct ensembl:ENSBTAG00000033967 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:BCL2L10
FADD GeneProduct ensembl:ENSBTAG00000018274 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:FADD
DFFB GeneProduct ensembl:ENSBTAG00000020015 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:DFFB
FAS GeneProduct ensembl:ENSBTAG00000010785 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:FAS
CASP8 GeneProduct ensembl:ENSBTAG00000015718 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:CASP8
TNFRSF10D GeneProduct ensembl:ENSBTAG00000047389 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:TNFRSF10D
BCL2 GeneProduct ensembl:ENSBTAG00000019302 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:BCL2
DIABLO GeneProduct ensembl:ENSBTAG00000004199 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:DIABLO
IRAK1 GeneProduct ensembl:ENSBTAG00000016085 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:IRAK1
NFKB1 GeneProduct ensembl:ENSBTAG00000020270 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:NFKB1
TNFRSF10D GeneProduct ensembl:ENSBTAG00000047389 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:TNFRSF10B
BCL2L1 GeneProduct ensembl:ENSBTAG00000006526 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:BCL2L1
TRAF3 GeneProduct ensembl:ENSBTAG00000013475 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:TRAF3
BIRC2 GeneProduct ensembl:ENSBTAG00000035735 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:BIRC2
BIRC7 GeneProduct ensembl:ENSBTAG00000004911 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:BIRC7
TNFRSF10D GeneProduct ensembl:ENSBTAG00000047389 HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:TNFRSF10C

References

  1. mir-29 regulates Mcl-1 protein expression and apoptosis. Mott JL, Kobayashi S, Bronk SF, Gores GJ. Oncogene. 2007 Sep 13;26(42):6133–40. PubMed Europe PMC Scholia
  2. Examination of apoptosis signaling in pancreatic cancer by computational signal transduction analysis. Rückert F, Dawelbait G, Winter C, Hartmann A, Denz A, Ammerpohl O, et al. PLoS One. 2010 Aug 19;5(8):e12243. PubMed Europe PMC Scholia