Apoptosis modulation and signaling (WP3148)
Bos taurus
Apoptosis, or cell death program, can be activated by various mechanisms within the extrinsic and the intrinsic pathway. While activation of cell death receptors leads to the engagement of the extrinsic pathway, the intrinsic pathway is activated by mitochondria during cellular stress, both resulting in an activation of caspases. In the present pathway we emphasized the activation of caspases by those two pathways in pancreatic cancer (PDAC) cells. Please notice, that PDAC cells are so called type-II cells. In these cells the activation of cell death receptors is not sufficient to activated caspases. By cleavage of Bid, type-II cells activate the intrinsic pathway as "amplification loop".
Authors
Martina Summer-Kutmon , Egon Willighagen , Denise Slenter , and Eric WeitzActivity
Discuss this pathway
Check for ongoing discussions or start your own.
Cited In
Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.
Organisms
Bos taurusCommunities
Annotations
Pathway Ontology
apoptotic cell death pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Ca2+ | Metabolite | hmdb:HMDB0000464 | |
| MAPK8 | GeneProduct | ensembl:ENSBTAG00000007876 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:MAPK8 |
| BIRC3 | GeneProduct | ensembl:ENSBTAG00000024918 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:BIRC3 |
| IL1R1 | GeneProduct | ensembl:ENSBTAG00000005273 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:IL1R1 |
| JUN | GeneProduct | ensembl:ENSBTAG00000004037 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:JUN |
| BIKBA | GeneProduct | ensembl:ENSBTAG00000016683 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:NFKBIA |
| DAXX | GeneProduct | ensembl:ENSBTAG00000016830 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:DAXX |
| BIRC5 | GeneProduct | ensembl:ENSBTAG00000013573 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:BIRC5 |
| BCL2A1 | GeneProduct | ensembl:ENSBTAG00000000735 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:BCL2A1 |
| CASP2 | GeneProduct | ensembl:ENSBTAG00000018159 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:835 |
| APAF1 | GeneProduct | ensembl:ENSBTAG00000021661 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:APAF1 |
| BOK | GeneProduct | ensembl:ENSBTAG00000008711 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:BOK |
| IKBKB | GeneProduct | ensembl:ENSBTAG00000007599 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:IKBKB |
| BCL2L11 | GeneProduct | ensembl:ENSBTAG00000024105 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:BCL2L11 |
| BAX | GeneProduct | ensembl:ENSBTAG00000013340 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:BAX |
| TOLLIP | GeneProduct | ensembl:ENSBTAG00000008237 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:TOLLIP |
| TNFRSF11B | GeneProduct | ensembl:ENSBTAG00000007423 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:TNFRSF11B |
| IL1R2 | GeneProduct | ensembl:ENSBTAG00000006343 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:IL1R2 |
| MADD | GeneProduct | ensembl:ENSBTAG00000021700 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:MADD |
| FLIP | GeneProduct | ensembl:ENSBTAG00000010998 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:CFLAR |
| AIFM1 | GeneProduct | ensembl:ENSBTAG00000006838 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9131 |
| TRADD | GeneProduct | ensembl:ENSBTAG00000012642 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:TRADD |
| FASLG | GeneProduct | ensembl:ENSBTAG00000032808 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:FASLG |
| TRAF6 | GeneProduct | ensembl:ENSBTAG00000036009 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:TRAF6 |
| CASP3 | GeneProduct | ensembl:ENSBTAG00000015874 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:CASP3 |
| CASP13 | GeneProduct | ensembl:ENSBTAG00000020884 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:837 |
| MAP3K14 | GeneProduct | ensembl:ENSBTAG00000007084 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:MAP3K14 |
| TNFRSF25 | GeneProduct | ensembl:ENSBTAG00000006519 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:TNFRSF25 |
| MAPK3 | GeneProduct | ensembl:ENSBTAG00000016156 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:MAPK3 |
| MYD88 | GeneProduct | ensembl:ENSBTAG00000000563 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:MYD88 |
| CASP6 | GeneProduct | ensembl:ENSBTAG00000012537 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:CASP6 |
| TNFRSF1B | GeneProduct | ensembl:ENSBTAG00000024928 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:TNFRSF1B |
| CRADD | GeneProduct | ensembl:ENSBTAG00000005107 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:CRADD |
| SEPT4 | GeneProduct | ensembl:ENSBTAG00000015368 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:SEPT4 |
| CASP9 | GeneProduct | ensembl:ENSBTAG00000002472 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:CASP9 |
| CDKN2A | GeneProduct | ensembl:ENSBTAG00000034220 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:CDKN2A |
| BLK | GeneProduct | ensembl:ENSBTAG00000005049 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:BLK |
| BAG3 | GeneProduct | ensembl:ENSBTAG00000013641 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:BAG3 |
| PIDD1 | GeneProduct | ensembl:ENSBTAG00000019634 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:55367 |
| BIRC6 | GeneProduct | ensembl:ENSBTAG00000027932 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:BIRC6 |
| CYCS | GeneProduct | ensembl:ENSBTAG00000022613 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:CYCS |
| MAP3K5 | GeneProduct | ensembl:ENSBTAG00000009065 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:MAP3K5 |
| BAD | GeneProduct | ensembl:ENSBTAG00000012511 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:BAD |
| BCL2L2 | GeneProduct | ensembl:ENSBTAG00000019692 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:BCL2L2 |
| BID2 | GeneProduct | ensembl:ENSBTAG00000013988 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:BID |
| TP53 | GeneProduct | ensembl:ENSBTAG00000001069 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7157 |
| CASP7 | GeneProduct | ensembl:ENSBTAG00000006615 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:CASP7 |
| TNFRSF1A | GeneProduct | ensembl:ENSBTAG00000004211 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:TNFRSF1A |
| HRK | GeneProduct | ensembl:ENSBTAG00000047484 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:HRK |
| PRKD1 | GeneProduct | ensembl:ENSBTAG00000012789 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5587 |
| HN1 | GeneProduct | ensembl:ENSBTAG00000030170 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:HN1 |
| NAIP | GeneProduct | ensembl:ENSBTAG00000003326 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4671 |
| CAPNS1 | GeneProduct | ensembl:ENSBTAG00000014872 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:CAPNS1 |
| AIFM2 | GeneProduct | ensembl:ENSBTAG00000001165 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:84883 |
| MCL1 | GeneProduct | ensembl:ENSBTAG00000031396 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:MCL1 |
| BMF | GeneProduct | ensembl:ENSBTAG00000012180 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:BMF |
| TNFRSF6B | GeneProduct | ensembl:ENSBTAG00000027407 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:TNFRSF6B |
| PTRH2 | GeneProduct | ensembl:ENSBTAG00000016710 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:PTRH2 |
| RIPK1 | GeneProduct | ensembl:ENSBTAG00000006378 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8737 |
| PTPN13 | GeneProduct | ensembl:ENSBTAG00000014947 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:PTPN13 |
| TNFRSF10D | GeneProduct | ensembl:ENSBTAG00000047389 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:TNFRSF10A |
| ENDOG | GeneProduct | ensembl:ENSBTAG00000012484 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:ENDOG |
| CASP2 | GeneProduct | ensembl:ENSBTAG00000018159 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:CASP2 |
| TNFSF10 | GeneProduct | ensembl:ENSBTAG00000018994 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:TNFSF10 |
| BAK1 | GeneProduct | ensembl:ENSBTAG00000000428 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:BAK1 |
| HTRA2 | GeneProduct | ensembl:ENSBTAG00000020124 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:HTRA2 |
| DFFA | GeneProduct | ensembl:ENSBTAG00000013535 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:DFFA |
| BNIP3 | GeneProduct | ensembl:ENSBTAG00000017804 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:BNIP3 |
| PEA15 | GeneProduct | ensembl:ENSBTAG00000005793 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8682 |
| FOS | GeneProduct | ensembl:ENSBTAG00000004322 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:FOS |
| Bcl-B | GeneProduct | ensembl:ENSBTAG00000033967 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:BCL2L10 |
| FADD | GeneProduct | ensembl:ENSBTAG00000018274 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:FADD |
| DFFB | GeneProduct | ensembl:ENSBTAG00000020015 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:DFFB |
| FAS | GeneProduct | ensembl:ENSBTAG00000010785 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:FAS |
| CASP8 | GeneProduct | ensembl:ENSBTAG00000015718 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:CASP8 |
| TNFRSF10D | GeneProduct | ensembl:ENSBTAG00000047389 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:TNFRSF10D |
| BCL2 | GeneProduct | ensembl:ENSBTAG00000019302 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:BCL2 |
| DIABLO | GeneProduct | ensembl:ENSBTAG00000004199 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:DIABLO |
| IRAK1 | GeneProduct | ensembl:ENSBTAG00000016085 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:IRAK1 |
| NFKB1 | GeneProduct | ensembl:ENSBTAG00000020270 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:NFKB1 |
| TNFRSF10D | GeneProduct | ensembl:ENSBTAG00000047389 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:TNFRSF10B |
| BCL2L1 | GeneProduct | ensembl:ENSBTAG00000006526 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:BCL2L1 |
| TRAF3 | GeneProduct | ensembl:ENSBTAG00000013475 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:TRAF3 |
| BIRC2 | GeneProduct | ensembl:ENSBTAG00000035735 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:BIRC2 |
| BIRC7 | GeneProduct | ensembl:ENSBTAG00000004911 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:BIRC7 |
| TNFRSF10D | GeneProduct | ensembl:ENSBTAG00000047389 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:TNFRSF10C |
References
- mir-29 regulates Mcl-1 protein expression and apoptosis. Mott JL, Kobayashi S, Bronk SF, Gores GJ. Oncogene. 2007 Sep 13;26(42):6133–40. PubMed Europe PMC Scholia
- Examination of apoptosis signaling in pancreatic cancer by computational signal transduction analysis. Rückert F, Dawelbait G, Winter C, Hartmann A, Denz A, Ammerpohl O, et al. PLoS One. 2010 Aug 19;5(8):e12243. PubMed Europe PMC Scholia