TCA cycle - detailed (WP296)
Saccharomyces cerevisiae
The tricarboxylic acid (TCA) cycle is a catabolic pathway that functions to generate energy and reduced cofactors from the oxidative decarboxylation of acetyl (C2) units. It occupies a central role in the metabolism of aerobic organisms, enabling the production of energy from carbohydrates, fatty acids, amino acids, and potentially any other molecule that can be converted or broken down to acetyl-CoA. In addition to its role in catabolism, the TCA cycle can also serve a biosynthetic role, as several intermediates in the pathway (e.g. oxaloacetate, succinate) provide carbon for the synthesis of amino acids or other biological compounds. Source: https://pathway.yeastgenome.org/
Authors
Jessica Heckman , Kristina Hanspers , Egon Willighagen , Daniela Digles , and Eric WeitzActivity
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Organisms
Saccharomyces cerevisiaeCommunities
Annotations
Pathway Ontology
energy metabolic pathway citric acid cycle pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| ubiquinone | Metabolite | cas:303-97-9 | |
| ADP | Metabolite | cas:58-64-0 | |
| NAD+ | Metabolite | chebi:57540 | |
| NADH | Metabolite | cas:53-84-9 | |
| H+ | Metabolite | chebi:15378 | |
| oxaloacetic acid | Metabolite | hmdb:HMDB0000223 | |
| cis-aconitate | Metabolite | chebi:16383 | |
| ATP | Metabolite | cas:1927-31-7 | |
| Coenzyme A | Metabolite | cas:64885-97-8 | |
| acetyl-CoA | Metabolite | cas:72-89-9 | |
| CHO3 | Metabolite | chebi:17544 | |
| pyruvate | Metabolite | hmdb:HMDB0000243 | |
| succinyl-CoA | Metabolite | chebi:57292 | |
| phosphate | Metabolite | cas:14265-44-2 | |
| D-threo-isocitrate | Metabolite | chebi:15562 | |
| 2-oxoglutarate | Metabolite | chebi:16810 | |
| citrate | Metabolite | chebi:16947 | |
| H2O | Metabolite | chebi:15377 | |
| ubiqionol | Metabolite | chebi:17976 | |
| CO2 | Metabolite | chebi:16526 | |
| succinate | Metabolite | chebi:30031 | |
| fumarate | Metabolite | chebi:29806 | |
| malate | Metabolite | chebi:15589 | |
| succinyl-CoA ligase 1 | GeneProduct | sgd:S000005668 | |
| citrate synthase 1 | GeneProduct | sgd:S000005284 | |
| cytoplasmic malate dehydrogenase | GeneProduct | sgd:S000005486 | |
| succinate dehydrogenase 3 | GeneProduct | sgd:S000001624 | |
| succinate dehydrogenase 1 | GeneProduct | sgd:S000001631 | |
| mitochondrial malate dehydrogenase | GeneProduct | sgd:S000001568 | |
| citrate synthase 2 | GeneProduct | sgd:S000000598 | |
| aconitase | GeneProduct | sgd:S000004295 | |
| isocitrate dehydrogenase 1 | GeneProduct | sgd:S000004982 | |
| succinyl-CoA ligase 2 | GeneProduct | sgd:S000003476 | |
| pyruvate carboxylase 2 | GeneProduct | sgd:S000000422 | |
| fumarate hydratase | GeneProduct | sgd:S000006183 | |
| aconitate hydratase | GeneProduct | sgd:S000003736 | |
| isocitrate dehydrogenase 2 | GeneProduct | sgd:S000005662 | |
| succinate dehydrogenase 4 | GeneProduct | sgd:S000002585 | |
| citrate synthase 3 | GeneProduct | sgd:S000006205 | |
| malate dehydrogenase | GeneProduct | sgd:S000002236 | |
| 2-ketoglutarate dehydrogenase | GeneProduct | sgd:S000001387 | |
| dihydrolipoyl transsuccinylase | GeneProduct | sgd:S000002555 | |
| pyruvate carboxylase 1 | GeneProduct | sgd:S000003030 | |
| succinate dehydrogenase 2 | GeneProduct | sgd:S000003964 | |
| dihydrolipoamide dehydrogenase | GeneProduct | sgd:S000001876 |